YIPF6_RAT
ID YIPF6_RAT Reviewed; 236 AA.
AC Q4QQU5;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Protein YIPF6;
DE AltName: Full=YIP1 family member 6;
GN Name=Yipf6;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: May be required for stable YIPF1 and YIPF2 protein
CC expression. {ECO:0000250|UniProtKB:Q96EC8}.
CC -!- SUBUNIT: Predominantly interacts with YIPF1 or YIPF2, but may also form
CC a ternary complex with YIPF1 and YIPF2. This interaction may stabilize
CC YIPF1 and YIPF2. {ECO:0000250|UniProtKB:Q96EC8}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q96EC8}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q96EC8}. Note=Evenly distributed between
CC cis- and trans-Golgi apparatus. Mainly localizes within medial-/trans-
CC Golgi and trans-Golgi network (TGN), while less so within cis-Golgi.
CC {ECO:0000250|UniProtKB:Q96EC8}.
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
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DR EMBL; BC097987; AAH97987.1; -; mRNA.
DR RefSeq; NP_001020918.1; NM_001025747.1.
DR RefSeq; XP_006257139.1; XM_006257077.3.
DR AlphaFoldDB; Q4QQU5; -.
DR STRING; 10116.ENSRNOP00000008705; -.
DR iPTMnet; Q4QQU5; -.
DR PhosphoSitePlus; Q4QQU5; -.
DR PaxDb; Q4QQU5; -.
DR Ensembl; ENSRNOT00000076795; ENSRNOP00000068121; ENSRNOG00000006642.
DR GeneID; 363476; -.
DR KEGG; rno:363476; -.
DR CTD; 286451; -.
DR RGD; 1566154; Yipf6.
DR eggNOG; KOG2946; Eukaryota.
DR GeneTree; ENSGT00940000153168; -.
DR InParanoid; Q4QQU5; -.
DR OMA; CVMPLTV; -.
DR OrthoDB; 1287193at2759; -.
DR PhylomeDB; Q4QQU5; -.
DR TreeFam; TF314563; -.
DR Reactome; R-RNO-432722; Golgi Associated Vesicle Biogenesis.
DR PRO; PR:Q4QQU5; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000006642; Expressed in testis and 20 other tissues.
DR ExpressionAtlas; Q4QQU5; baseline and differential.
DR GO; GO:0005801; C:cis-Golgi network; ISO:RGD.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; ISO:RGD.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005797; C:Golgi medial cisterna; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000138; C:Golgi trans cisterna; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0060576; P:intestinal epithelial cell development; ISO:RGD.
DR InterPro; IPR045231; Yip1/4-like.
DR InterPro; IPR006977; Yip1_dom.
DR PANTHER; PTHR21236; PTHR21236; 1.
DR Pfam; PF04893; Yip1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q96EC8"
FT CHAIN 2..236
FT /note="Protein YIPF6"
FT /id="PRO_0000242670"
FT TOPO_DOM 2..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q96EC8"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..116
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..185
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..213
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..236
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q96EC8"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q96EC8"
FT MOD_RES 7
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 236 AA; 26107 MW; E71848CFA6E7A623 CRC64;
MAEAEDSPGE QEATSSKPLF AGLSDVSISQ DIPIEGEITI PSGTRAQECD SSTLNESIRR
TIMRDLKAVG RKFMHVLYPR KSNTLLRDWD LWGPLILCVS LALMLQKSSV EGKRDGGSPE
FAEVFVIIWF GAVTITLNSK LLGGNISFFQ SLCVLGYCVL PLNIAMLICR LLLLAGQGPI
NFMIRLFVVL VMFAWSVIAS TAFLADCQPP NRKALAVYPV FLFYFVVSWM ILTFTP
