ID   CBIF_METJA              Reviewed;         259 AA.
AC   Q58973;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Cobalt-precorrin-4 C(11)-methyltransferase;
DE            EC=2.1.1.271;
DE   AltName: Full=Cobalt-precorrin-3 methylase;
GN   Name=cbiF; OrderedLocusNames=MJ1578;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Catalyzes the methylation of C-11 in cobalt-precorrin-4 to
CC       form cobalt-precorrin-5A. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co-precorrin-4 + S-adenosyl-L-methionine = Co-precorrin-5A +
CC         H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:26277,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:60061, ChEBI:CHEBI:60062; EC=2.1.1.271;
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC       step 4/10.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; L77117; AAB99599.1; -; Genomic_DNA.
DR   PIR; A64497; A64497.
DR   RefSeq; WP_010871103.1; NC_000909.1.
DR   AlphaFoldDB; Q58973; -.
DR   SMR; Q58973; -.
DR   STRING; 243232.MJ_1578; -.
DR   EnsemblBacteria; AAB99599; AAB99599; MJ_1578.
DR   GeneID; 1452487; -.
DR   KEGG; mja:MJ_1578; -.
DR   eggNOG; arCOG00645; Archaea.
DR   HOGENOM; CLU_011276_7_1_2; -.
DR   InParanoid; Q58973; -.
DR   OMA; WSAMGEQ; -.
DR   OrthoDB; 67633at2157; -.
DR   PhylomeDB; Q58973; -.
DR   UniPathway; UPA00148; UER00226.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0046026; F:precorrin-4 C11-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR   CDD; cd11641; Precorrin-4_C11-MT; 1.
DR   Gene3D; 3.30.950.10; -; 1.
DR   Gene3D; 3.40.1010.10; -; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR006362; Cbl_synth_CobM/CibF.
DR   InterPro; IPR006366; CobA/CysG_C.
DR   InterPro; IPR003043; Uropor_MeTrfase_CS.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF53790; SSF53790; 1.
DR   TIGRFAMs; TIGR01469; cobA_cysG_Cterm; 1.
DR   TIGRFAMs; TIGR01465; cobM_cbiF; 1.
DR   PROSITE; PS00839; SUMT_1; 1.
DR   PROSITE; PS00840; SUMT_2; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis; Methyltransferase; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..259
FT                   /note="Cobalt-precorrin-4 C(11)-methyltransferase"
FT                   /id="PRO_0000150399"
SQ   SEQUENCE   259 AA;  29004 MW;  C5DB9E3C78143521 CRC64;
     MDNNRKVIIV GAGPGDPELI TIKGKKAIEE ADVIIYAGSL VNEKLLEYNK KNAEIYNSAN
     MNLEEIIDVM VKAVNQGKKV VRLHTGDPSI YGAIKEQIDE LSKYGIDVEI IPGVSSLFAA
     TASLKVELTL PEVSQTVIIT RPEGRTPMPE KEKLRDLAKH QSTMAIFLGV SMIDKVVKEL
     IEGGYREETP VAVVYHASWD DEKIVRGTLK DIAEKVKKEG IKKTALIIVG EVLNPKYYAY
     SKLYDKNFEH EYRKSHKKF