YIPF7_HUMAN
ID YIPF7_HUMAN Reviewed; 280 AA.
AC Q8N8F6; Q3SY21; Q3SY22;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Protein YIPF7;
DE AltName: Full=Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 9;
DE AltName: Full=YIP1 family member 7;
GN Name=YIPF7; Synonyms=FINGER9, YIP1B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT THR-54.
RC TISSUE=Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, AND TOPOLOGY.
RX PubMed=27999994; DOI=10.1007/s00418-016-1527-3;
RA Kranjc T., Dempsey E., Cagney G., Nakamura N., Shields D.C., Simpson J.C.;
RT "Functional characterisation of the YIPF protein family in mammalian
RT cells.";
RL Histochem. Cell Biol. 147:439-451(2017).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9JIM5}; Multi-pass membrane protein. Golgi
CC apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:27999994}.
CC Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000269|PubMed:27999994}. Note=Evenly distributed between cis- and
CC trans-Golgi apparatus. {ECO:0000269|PubMed:27999994}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8N8F6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N8F6-2; Sequence=VSP_033435;
CC Name=3;
CC IsoId=Q8N8F6-3; Sequence=VSP_033431, VSP_033432;
CC Name=4;
CC IsoId=Q8N8F6-4; Sequence=VSP_033433, VSP_033434;
CC -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-25 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AK096895; BAC04887.1; -; mRNA.
DR EMBL; AC093852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC096586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC108478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC103995; AAI03996.1; -; mRNA.
DR EMBL; BC103996; AAI03997.1; -; mRNA.
DR RefSeq; NP_872398.2; NM_182592.2. [Q8N8F6-1]
DR AlphaFoldDB; Q8N8F6; -.
DR STRING; 9606.ENSP00000332772; -.
DR iPTMnet; Q8N8F6; -.
DR PhosphoSitePlus; Q8N8F6; -.
DR BioMuta; YIPF7; -.
DR DMDM; 189030344; -.
DR PaxDb; Q8N8F6; -.
DR PeptideAtlas; Q8N8F6; -.
DR PRIDE; Q8N8F6; -.
DR Antibodypedia; 23722; 31 antibodies from 14 providers.
DR DNASU; 285525; -.
DR Ensembl; ENST00000332990.6; ENSP00000332772.6; ENSG00000177752.15.
DR GeneID; 285525; -.
DR KEGG; hsa:285525; -.
DR UCSC; uc062wht.1; human. [Q8N8F6-1]
DR CTD; 285525; -.
DR DisGeNET; 285525; -.
DR GeneCards; YIPF7; -.
DR HGNC; HGNC:26825; YIPF7.
DR HPA; ENSG00000177752; Group enriched (skeletal muscle, tongue).
DR MIM; 619754; gene.
DR neXtProt; NX_Q8N8F6; -.
DR PharmGKB; PA142670550; -.
DR VEuPathDB; HostDB:ENSG00000177752; -.
DR eggNOG; KOG3103; Eukaryota.
DR InParanoid; Q8N8F6; -.
DR OrthoDB; 1457080at2759; -.
DR PhylomeDB; Q8N8F6; -.
DR TreeFam; TF313100; -.
DR PathwayCommons; Q8N8F6; -.
DR BioGRID-ORCS; 285525; 15 hits in 1063 CRISPR screens.
DR GenomeRNAi; 285525; -.
DR Pharos; Q8N8F6; Tdark.
DR PRO; PR:Q8N8F6; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8N8F6; protein.
DR Bgee; ENSG00000177752; Expressed in quadriceps femoris and 92 other tissues.
DR ExpressionAtlas; Q8N8F6; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IBA:GO_Central.
DR InterPro; IPR045231; Yip1/4-like.
DR InterPro; IPR006977; Yip1_dom.
DR PANTHER; PTHR21236; PTHR21236; 1.
DR Pfam; PF04893; Yip1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Endoplasmic reticulum; Golgi apparatus; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..280
FT /note="Protein YIPF7"
FT /id="PRO_0000333007"
FT TOPO_DOM 1..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:27999994"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..196
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..220
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 43..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 64..68
FT /note="QQAGE -> TWNPF (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033431"
FT VAR_SEQ 69..280
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033432"
FT VAR_SEQ 118..132
FT /note="ELGIHFDHIWQKTLT -> DKNLESILITYGKKL (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033433"
FT VAR_SEQ 133..280
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033434"
FT VAR_SEQ 167..280
FT /note="AGKVQFGYVYGMSAIGCLVIHALLNLMSSSGVSYGCVASVLGYCLLPMVILS
FT GCAMFFSLQGIFGIMSSLVIIGWCSLSASKIFIAALHMEGQQLLVAYPCAILYGLFALL
FT TIF -> VMCHRKHQILMLVLSSAGFEAICINIRETVSPYIVNFLSERE (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033435"
FT VARIANT 54
FT /note="A -> T (in dbSNP:rs2348353)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_043036"
FT CONFLICT 50
FT /note="N -> D (in Ref. 1; BAC04887)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="K -> E (in Ref. 1; BAC04887)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 280 AA; 30632 MW; AF30804CB8B3FB36 CRC64;
MDLLKISHTK LHLLEDLSIK NKQRMSNLAQ FDSDFYQSNF TIDNQEQSGN DSNAYGNLYG
SRKQQAGEQP QPASFVPSEM LMSSGYAGQF FQPASNSDYY SQSPYIDSFD EEPPLLEELG
IHFDHIWQKT LTVLNPMKPV DGSIMNETDL TGPILFCVAL GATLLLAGKV QFGYVYGMSA
IGCLVIHALL NLMSSSGVSY GCVASVLGYC LLPMVILSGC AMFFSLQGIF GIMSSLVIIG
WCSLSASKIF IAALHMEGQQ LLVAYPCAIL YGLFALLTIF
