YIPP_DROME
ID YIPP_DROME Reviewed; 121 AA.
AC Q9XZF0;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein yippee;
GN Name=Yippee; ORFNames=CG1989;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND INTERACTION WITH HEMOLIN.
RX PubMed=11240639; DOI=10.1046/j.1365-2583.2001.00239.x;
RA Roxstroem-Lindquist K., Faye I.;
RT "The Drosophila gene Yippee reveals a novel family of putative zinc binding
RT proteins highly conserved among eukaryotes.";
RL Insect Mol. Biol. 10:77-86(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- SUBUNIT: Interacts with hemolin. {ECO:0000269|PubMed:11240639}.
CC -!- SIMILARITY: Belongs to the yippee family. {ECO:0000305}.
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DR EMBL; AF172939; AAD47881.1; -; mRNA.
DR EMBL; AF139189; AAD28537.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF48266.1; -; Genomic_DNA.
DR RefSeq; NP_572882.1; NM_132654.4.
DR AlphaFoldDB; Q9XZF0; -.
DR BioGRID; 58675; 6.
DR DIP; DIP-22333N; -.
DR IntAct; Q9XZF0; 1.
DR STRING; 7227.FBpp0073620; -.
DR PaxDb; Q9XZF0; -.
DR PRIDE; Q9XZF0; -.
DR DNASU; 32295; -.
DR EnsemblMetazoa; FBtr0073789; FBpp0073620; FBgn0026749.
DR GeneID; 32295; -.
DR KEGG; dme:Dmel_CG1989; -.
DR UCSC; CG1989-RA; d. melanogaster.
DR CTD; 32295; -.
DR FlyBase; FBgn0026749; Yippee.
DR VEuPathDB; VectorBase:FBgn0026749; -.
DR eggNOG; KOG3399; Eukaryota.
DR GeneTree; ENSGT00940000154800; -.
DR HOGENOM; CLU_043857_1_1_1; -.
DR InParanoid; Q9XZF0; -.
DR OMA; WVYEFAT; -.
DR PhylomeDB; Q9XZF0; -.
DR Reactome; R-DME-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 32295; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 32295; -.
DR PRO; PR:Q9XZF0; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0026749; Expressed in eye disc (Drosophila) and 24 other tissues.
DR ExpressionAtlas; Q9XZF0; baseline and differential.
DR Genevisible; Q9XZF0; DM.
DR GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; NAS:UniProtKB.
DR InterPro; IPR034751; Yippee.
DR InterPro; IPR004910; Yippee/Mis18/Cereblon.
DR InterPro; IPR039058; Yippee_fam.
DR PANTHER; PTHR13848; PTHR13848; 1.
DR Pfam; PF03226; Yippee-Mis18; 1.
DR PROSITE; PS51792; YIPPEE; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..121
FT /note="Protein yippee"
FT /id="PRO_0000212379"
FT DOMAIN 13..110
FT /note="Yippee"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 17
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 20
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 73
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
FT BINDING 76
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01128"
SQ SEQUENCE 121 AA; 13743 MW; 910FFBA1D775B580 CRC64;
MGRIFLEHLG GLKLFNCAQC HTNLTNRSQL ISTRFTGATG RAYLFKRVVN LTFSNIQERV
MLTGRHMVRD VMCKNCGAKL GWMYEFATEE SQKYKEGRVI LEYALITEAE GFPSEAATTS
H
