ID   CBIF_SALTI              Reviewed;         257 AA.
AC   P0A2H0; Q05630;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Cobalt-precorrin-4 C(11)-methyltransferase;
DE            EC=2.1.1.271;
DE   AltName: Full=Cobalt-precorrin-3 methylase;
GN   Name=cbiF; OrderedLocusNames=STY2234, t0845;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Catalyzes the methylation of C-11 in cobalt-precorrin-4 to
CC       form cobalt-precorrin-5A. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co-precorrin-4 + S-adenosyl-L-methionine = Co-precorrin-5A +
CC         H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:26277,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:60061, ChEBI:CHEBI:60062; EC=2.1.1.271;
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC       step 4/10.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AL513382; CAD02390.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO68532.1; -; Genomic_DNA.
DR   RefSeq; NP_456580.1; NC_003198.1.
DR   RefSeq; WP_000004870.1; NZ_WSUR01000002.1.
DR   AlphaFoldDB; P0A2H0; -.
DR   SMR; P0A2H0; -.
DR   STRING; 220341.16503261; -.
DR   EnsemblBacteria; AAO68532; AAO68532; t0845.
DR   KEGG; stt:t0845; -.
DR   KEGG; sty:STY2234; -.
DR   PATRIC; fig|220341.7.peg.2253; -.
DR   eggNOG; COG2875; Bacteria.
DR   HOGENOM; CLU_011276_7_1_6; -.
DR   OMA; WSAMGEQ; -.
DR   UniPathway; UPA00148; UER00226.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0046026; F:precorrin-4 C11-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd11641; Precorrin-4_C11-MT; 1.
DR   Gene3D; 3.30.950.10; -; 1.
DR   Gene3D; 3.40.1010.10; -; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR006362; Cbl_synth_CobM/CibF.
DR   InterPro; IPR003043; Uropor_MeTrfase_CS.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF53790; SSF53790; 1.
DR   TIGRFAMs; TIGR01465; cobM_cbiF; 1.
DR   PROSITE; PS00839; SUMT_1; 1.
DR   PROSITE; PS00840; SUMT_2; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis; Methyltransferase; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..257
FT                   /note="Cobalt-precorrin-4 C(11)-methyltransferase"
FT                   /id="PRO_0000150393"
SQ   SEQUENCE   257 AA;  28376 MW;  17D2E4AB2B5593F1 CRC64;
     MSETFDPRCV WFVGAGPGDR ELITLKGYRL LQQAQVVIYA GSLINTELLD YCPAQAERYD
     SAELHLEQII ELMAAGVKAG KTVVRLQTGD VSLYGSVREQ GEELTRRGID WQVVPGVSAF
     LGAAAELGVE YTVPEVSQSL IITRLEGRTP VPAREQLEAF ASHQTSMAIY LSVQRIHRVA
     ERLIAGGYPA TTPVAVIYKA TWPESQTVRG TLADISDKVR DAGIRKTALI LVGNFLGKEY
     HYSRLYAADF SHEYRKA