ID   CBIF_SALTY              Reviewed;         257 AA.
AC   P0A2G9; Q05630;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Cobalt-precorrin-4 C(11)-methyltransferase;
DE            EC=2.1.1.271;
DE   AltName: Full=Cobalt-precorrin-3 methylase;
GN   Name=cbiF; OrderedLocusNames=STM2029;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF N-TERMINUS.
RC   STRAIN=LT2;
RX   PubMed=8501034; DOI=10.1128/jb.175.11.3303-3316.1993;
RA   Roth J.R., Lawrence J.G., Rubenfield M., Kieffer-Higgins S., Church G.M.;
RT   "Characterization of the cobalamin (vitamin B12) biosynthetic genes of
RT   Salmonella typhimurium.";
RL   J. Bacteriol. 175:3303-3316(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-11.
RX   PubMed=1451790; DOI=10.1016/0014-5793(92)80213-z;
RA   Roessner C.A., Warren M.J., Santander P.J., Atshaves B.P., Ozaki S.,
RA   Stolowich N.J., Iida K., Scott A.I.;
RT   "Expression of 9 Salmonella typhimurium enzymes for cobinamide synthesis.
RT   Identification of the 11-methyl and 20-methyl transferases of corrin
RT   biosynthesis.";
RL   FEBS Lett. 301:73-78(1992).
RN   [4]
RP   FUNCTION, AND CATALYTIC ACTIVITY.
RX   PubMed=16866557; DOI=10.1021/ja062940a;
RA   Kajiwara Y., Santander P.J., Roessner C.A., Perez L.M., Scott A.I.;
RT   "Genetically engineered synthesis and structural characterization of
RT   cobalt-precorrin 5A and -5B, two new intermediates on the anaerobic pathway
RT   to vitamin B12: definition of the roles of the CbiF and CbiG enzymes.";
RL   J. Am. Chem. Soc. 128:9971-9978(2006).
CC   -!- FUNCTION: Catalyzes the methylation of C-11 in cobalt-precorrin-4 to
CC       form cobalt-precorrin-5A. {ECO:0000269|PubMed:16866557}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co-precorrin-4 + S-adenosyl-L-methionine = Co-precorrin-5A +
CC         H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:26277,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:60061, ChEBI:CHEBI:60062; EC=2.1.1.271;
CC         Evidence={ECO:0000269|PubMed:16866557};
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC       step 4/10.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L12006; AAA27258.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20933.1; -; Genomic_DNA.
DR   RefSeq; NP_460974.1; NC_003197.2.
DR   RefSeq; WP_000004870.1; NC_003197.2.
DR   AlphaFoldDB; P0A2G9; -.
DR   SMR; P0A2G9; -.
DR   STRING; 99287.STM2029; -.
DR   PaxDb; P0A2G9; -.
DR   EnsemblBacteria; AAL20933; AAL20933; STM2029.
DR   GeneID; 1253550; -.
DR   KEGG; stm:STM2029; -.
DR   PATRIC; fig|99287.12.peg.2151; -.
DR   HOGENOM; CLU_011276_7_1_6; -.
DR   OMA; WSAMGEQ; -.
DR   PhylomeDB; P0A2G9; -.
DR   BioCyc; MetaCyc:MON-13218; -.
DR   BioCyc; SENT99287:STM2029-MON; -.
DR   UniPathway; UPA00148; UER00226.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0046026; F:precorrin-4 C11-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd11641; Precorrin-4_C11-MT; 1.
DR   Gene3D; 3.30.950.10; -; 1.
DR   Gene3D; 3.40.1010.10; -; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR006362; Cbl_synth_CobM/CibF.
DR   InterPro; IPR003043; Uropor_MeTrfase_CS.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF53790; SSF53790; 1.
DR   TIGRFAMs; TIGR01465; cobM_cbiF; 1.
DR   PROSITE; PS00839; SUMT_1; 1.
DR   PROSITE; PS00840; SUMT_2; 1.
PE   1: Evidence at protein level;
KW   Cobalamin biosynthesis; Direct protein sequencing; Methyltransferase;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..257
FT                   /note="Cobalt-precorrin-4 C(11)-methyltransferase"
FT                   /id="PRO_0000150394"
SQ   SEQUENCE   257 AA;  28376 MW;  17D2E4AB2B5593F1 CRC64;
     MSETFDPRCV WFVGAGPGDR ELITLKGYRL LQQAQVVIYA GSLINTELLD YCPAQAERYD
     SAELHLEQII ELMAAGVKAG KTVVRLQTGD VSLYGSVREQ GEELTRRGID WQVVPGVSAF
     LGAAAELGVE YTVPEVSQSL IITRLEGRTP VPAREQLEAF ASHQTSMAIY LSVQRIHRVA
     ERLIAGGYPA TTPVAVIYKA TWPESQTVRG TLADISDKVR DAGIRKTALI LVGNFLGKEY
     HYSRLYAADF SHEYRKA