YIV5_YEAST
ID YIV5_YEAST Reviewed; 254 AA.
AC P40579; D6VVW6;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Uncharacterized oxidoreductase YIR035C;
DE EC=1.-.-.-;
GN OrderedLocusNames=YIR035C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169870;
RA Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL Nature 387:84-87(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- MISCELLANEOUS: Present with 2370 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z38061; CAA86195.1; -; Genomic_DNA.
DR EMBL; AY692591; AAT92610.1; -; Genomic_DNA.
DR EMBL; BK006942; DAA08582.1; -; Genomic_DNA.
DR PIR; S48497; S48497.
DR RefSeq; NP_012301.3; NM_001179557.3.
DR PDB; 3KZV; X-ray; 2.00 A; A=1-254.
DR PDB; 6UHX; X-ray; 2.75 A; A/B=1-254.
DR PDBsum; 3KZV; -.
DR PDBsum; 6UHX; -.
DR AlphaFoldDB; P40579; -.
DR SMR; P40579; -.
DR BioGRID; 35026; 49.
DR DIP; DIP-4612N; -.
DR IntAct; P40579; 3.
DR MINT; P40579; -.
DR STRING; 4932.YIR035C; -.
DR iPTMnet; P40579; -.
DR MaxQB; P40579; -.
DR PaxDb; P40579; -.
DR PRIDE; P40579; -.
DR EnsemblFungi; YIR035C_mRNA; YIR035C; YIR035C.
DR GeneID; 854853; -.
DR KEGG; sce:YIR035C; -.
DR SGD; S000001474; YIR035C.
DR VEuPathDB; FungiDB:YIR035C; -.
DR eggNOG; KOG1204; Eukaryota.
DR GeneTree; ENSGT00940000176436; -.
DR HOGENOM; CLU_010194_2_11_1; -.
DR InParanoid; P40579; -.
DR OMA; SHVDEWR; -.
DR BioCyc; YEAST:G3O-31449-MON; -.
DR EvolutionaryTrace; P40579; -.
DR PRO; PR:P40579; -.
DR Proteomes; UP000002311; Chromosome IX.
DR RNAct; P40579; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0050664; F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor; IBA:GO_Central.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Oxidoreductase; Reference proteome.
FT CHAIN 1..254
FT /note="Uncharacterized oxidoreductase YIR035C"
FT /id="PRO_0000054870"
FT ACT_SITE 150
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 6..30
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 137
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT STRAND 4..7
FT /evidence="ECO:0007829|PDB:3KZV"
FT HELIX 13..25
FT /evidence="ECO:0007829|PDB:3KZV"
FT STRAND 30..36
FT /evidence="ECO:0007829|PDB:3KZV"
FT HELIX 38..48
FT /evidence="ECO:0007829|PDB:3KZV"
FT HELIX 49..51
FT /evidence="ECO:0007829|PDB:3KZV"
FT STRAND 52..57
FT /evidence="ECO:0007829|PDB:3KZV"
FT HELIX 62..76
FT /evidence="ECO:0007829|PDB:3KZV"
FT STRAND 81..85
FT /evidence="ECO:0007829|PDB:3KZV"
FT TURN 93..96
FT /evidence="ECO:0007829|PDB:3KZV"
FT HELIX 100..110
FT /evidence="ECO:0007829|PDB:3KZV"
FT HELIX 112..128
FT /evidence="ECO:0007829|PDB:3KZV"
FT STRAND 131..135
FT /evidence="ECO:0007829|PDB:3KZV"
FT HELIX 138..140
FT /evidence="ECO:0007829|PDB:6UHX"
FT HELIX 148..155
FT /evidence="ECO:0007829|PDB:3KZV"
FT HELIX 157..167
FT /evidence="ECO:0007829|PDB:3KZV"
FT STRAND 171..177
FT /evidence="ECO:0007829|PDB:3KZV"
FT HELIX 184..191
FT /evidence="ECO:0007829|PDB:6UHX"
FT TURN 195..197
FT /evidence="ECO:0007829|PDB:3KZV"
FT HELIX 200..210
FT /evidence="ECO:0007829|PDB:3KZV"
FT HELIX 219..231
FT /evidence="ECO:0007829|PDB:3KZV"
FT HELIX 235..237
FT /evidence="ECO:0007829|PDB:3KZV"
FT STRAND 241..243
FT /evidence="ECO:0007829|PDB:3KZV"
FT HELIX 247..252
FT /evidence="ECO:0007829|PDB:3KZV"
SQ SEQUENCE 254 AA; 27481 MW; 916A5A460BE59F78 CRC64;
MGKVILVTGV SRGIGKSIVD VLFSLDKDTV VYGVARSEAP LKKLKEKYGD RFFYVVGDIT
EDSVLKQLVN AAVKGHGKID SLVANAGVLE PVQNVNEIDV NAWKKLYDIN FFSIVSLVGI
ALPELKKTNG NVVFVSSDAC NMYFSSWGAY GSSKAALNHF AMTLANEERQ VKAIAVAPGI
VDTDMQVNIR ENVGPSSMSA EQLKMFRGLK ENNQLLDSSV PATVYAKLAL HGIPDGVNGQ
YLSYNDPALA DFMP
