YIW2_SCHPO
ID YIW2_SCHPO Reviewed; 1717 AA.
AC Q9P7T8;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Uncharacterized helicase C694.02;
DE EC=3.6.4.-;
GN ORFNames=SPAC694.02;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000305}.
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DR EMBL; CU329670; CAB71840.1; -; Genomic_DNA.
DR PIR; T50247; T50247.
DR RefSeq; NP_594482.1; NM_001019911.2.
DR AlphaFoldDB; Q9P7T8; -.
DR BioGRID; 279756; 58.
DR STRING; 4896.SPAC694.02.1; -.
DR iPTMnet; Q9P7T8; -.
DR MaxQB; Q9P7T8; -.
DR PaxDb; Q9P7T8; -.
DR PRIDE; Q9P7T8; -.
DR EnsemblFungi; SPAC694.02.1; SPAC694.02.1:pep; SPAC694.02.
DR GeneID; 2543333; -.
DR KEGG; spo:SPAC694.02; -.
DR PomBase; SPAC694.02; -.
DR VEuPathDB; FungiDB:SPAC694.02; -.
DR eggNOG; KOG0949; Eukaryota.
DR HOGENOM; CLU_002305_2_0_1; -.
DR InParanoid; Q9P7T8; -.
DR OMA; RRGDIWF; -.
DR PhylomeDB; Q9P7T8; -.
DR PRO; PR:Q9P7T8; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; ISM:PomBase.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; Helicase; Hydrolase; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..1717
FT /note="Uncharacterized helicase C694.02"
FT /id="PRO_0000310784"
FT DOMAIN 744..914
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 1160..1334
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 446..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 864..867
FT /note="DEAH box"
FT COMPBIAS 494..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 757..764
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 1717 AA; 195059 MW; 6E3C22EA7DCFEA5B CRC64;
MSEEIAKLTT VQNYRLVDLI GDFAGEELFL IDGDSLIFHI LAKDSQFLAK NGVQILYAIY
LLEKELARFK SARLNFCIVF FKNWEALYSQ YDGILHASLL LFRRVAIRHL RKHVPVYVFK
SLGDSQWSIF IAKHRPYGFM VLDSNQNTKE GGLVISDEQV MVFKSFIFFA LSDGVPVALL
GSYQFVDNKI LVCILPSFFT RSSESVENAS NLISDYLKKF GKPRQSIELP DIAVDACPSN
ASRIQTLSAA WLLLNEKSDL NVDLCKILII LTCMLEELSL NDRFQPAFPL YEDPAIQKFI
ISYLNATNTI LQLLDSKVDG FHDIFDGRLF IRLVVDAALG EFCIPDICRE SALSLWKLIL
DIAPDAGDLF DFPSLSSISK DLCVPIETPV SEIDISLTAY NDPVISPYYD TEEWNLEQRE
EPGIETVLDF SKLRINDKTM TSKRFDDLSA TRKTGDNTKD RKQANKVRRQ DQFFISHIQK
YASSLTGAKG GQLKRQTIFT QGPNSTKESK QAVKEETSVK NSPKGKNTKN GKAEKEKPGK
KSKAPKLSKA EQIRAEIAAR KVEKEENKNE VIWNETKNDL GRIKDLNLRA GRLAQLLNTR
TYDPYIENEM RLYRIRVLLS LWTACCVTDE GKEKNIKIAV EIFREISIVY PNPITKQVKA
ALDETLTALG FENVIRKMKK LESKPLSFPF VLPDLEDEEF DLEVPYTSPT FQLLHFGEYM
ERSMGSAPDS RVAFDPDEWQ RETLDILDRD ESVFVVAPTS SGKTFISFYA MEKVLRDNDD
GVVIYVAPTK ALVNQLSAEV YARFNKHYPH AGQTVWSVYT RDYRINNPTN CQVLITVPHV
LQSMLLQPAL ANAWCPKIRR IIFDEIHCIG QMEDGLVEEQ LLLLAPCPIV ALSATVGNPQ
EFQVWLSALQ RAHSYPIHLI VHEHRYSDLR KFVYGGAKEF NGLQEEGDLG QIAFIHPAAA
MSFSDGSTTN LAFEPRDCLQ LYYAMKLVSK GDFKISRKLD PDRYFEDIPF IKKVDAVGYE
KKIKATIDTW ASLPNAFAPN SPFQALIKHF CSEPQKVVNS QLELHNSAYS LDAISQNLLP
MLKDLHSKEL LPAICFNYDR QECEYLAEIV FKTLVEKERE WRENSEEWKE KMREYKKWQS
TANQRAKQME KFEKSATEKQ KEQALKEAGD ISWIEFFDPE EPSPEFSFAG AKSTYGKEEL
YRDLEALRRR QAVPEWYVDA LYRGIGIHHS GLNRRYRQIV EVLFRCGQLT VVIATRTLSL
GINMPCRTVV FLGDSLQLNA LNFHQAAGRA GRRGFDLLGH VGFLGVPLHK IYRLLTTKLW
DIQGQFPLTT SLVLQLSQLI SGSQAGPFAR DTIHALMDEP KFMANGSILS NQVNHHLRFV
IEYLRREGLL DVYGNPINLA SLTMHLYYTE PSNYAFMNLL KAGVFHKIAE KFATEKFEAM
RDTVVILCHL FGRIRMNEQY VMTLEGSTDL AQSTVVLPPL PTEIADVLDA HDQRVLDLYK
TYAWYYQKHG NIGVAANKLP LSNTTIEGSA KLPSSLSVGV MSEFCGLAGY NESMVGTTSS
FLDKVPDGIF LKTSRLPIFE ANKAPYNAYL LDFFTHGSVD MLIEQNNLKQ SEIWFVLNDF
SLVLATICSC LGNLLNLVTD EDIENAMSAL EGSNAVQATT ESEATGADWM QNMNGNYSTT
LASPELEEKM DMNLFKVYCM FLEVRNQFDA KFRKMWA
