ID   CBIH_METJA              Reviewed;         249 AA.
AC   Q58223;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Probable cobalt-factor III C(17)-methyltransferase;
DE            EC=2.1.1.-;
DE   AltName: Full=Cobalt-precorrin-3 methyltransferase;
DE            Short=Cobalt-precorrin-3 methylase;
GN   Name=cbiH; Synonyms=cobJ; OrderedLocusNames=MJ0813;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Methyltransferase that likely catalyzes the ring contraction
CC       and methylation of C-17 in cobalt-factor III to form cobalt-factor IV.
CC       May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co(II)-factor III + H(+) + S-adenosyl-L-methionine = Co(II)-
CC         factor IV + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:45852,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:73299, ChEBI:CHEBI:85471;
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC       step 3/10.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; L77117; AAB98812.1; -; Genomic_DNA.
DR   PIR; E64401; E64401.
DR   RefSeq; WP_010870324.1; NC_000909.1.
DR   AlphaFoldDB; Q58223; -.
DR   SMR; Q58223; -.
DR   STRING; 243232.MJ_0813; -.
DR   EnsemblBacteria; AAB98812; AAB98812; MJ_0813.
DR   GeneID; 1451696; -.
DR   KEGG; mja:MJ_0813; -.
DR   eggNOG; arCOG00647; Archaea.
DR   HOGENOM; CLU_047948_2_0_2; -.
DR   InParanoid; Q58223; -.
DR   OMA; VWDDRMV; -.
DR   OrthoDB; 49464at2157; -.
DR   PhylomeDB; Q58223; -.
DR   UniPathway; UPA00148; UER00225.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR   Gene3D; 3.30.950.10; -; 1.
DR   Gene3D; 3.40.1010.10; -; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF53790; SSF53790; 1.
DR   TIGRFAMs; TIGR01466; cobJ_cbiH; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis; Methyltransferase; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..249
FT                   /note="Probable cobalt-factor III C(17)-methyltransferase"
FT                   /id="PRO_0000150403"
SQ   SEQUENCE   249 AA;  28131 MW;  EE25D9F73D0C0911 CRC64;
     MLYVVGIGSG NERHFTKEAE EILNKVDLIV CYKNYKKFVE RLNKPIYTTG MTREIDRVDY
     ALKEAKDKDV ALVSSGDATI YGLASLAYEI NAVKGYNVDI KVVPGITACS LASAILGSPL
     NHDFVVISFS DLLTPLETIL KRFRCALEGD FVICIYNPLS KRRKEPFLKA MEILAEFAKD
     KDYIIGIVKN AGRNKEEVVI TNFKDLYKNL EKYLEFIDMN TILIIGNSST KIINGKMITP
     RGYLDKYKI