ID   CBIH_METTH              Reviewed;         351 AA.
AC   O27454;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Probable cobalt-factor III C(17)-methyltransferase;
DE            EC=2.1.1.-;
DE   AltName: Full=Cobalt-precorrin-3 methyltransferase;
DE            Short=Cobalt-precorrin-3 methylase;
GN   Name=cbiH; Synonyms=cobJ; OrderedLocusNames=MTH_1403;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Methyltransferase that likely catalyzes the ring contraction
CC       and methylation of C-17 in cobalt-factor III to form cobalt-factor IV.
CC       May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co(II)-factor III + H(+) + S-adenosyl-L-methionine = Co(II)-
CC         factor IV + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:45852,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:73299, ChEBI:CHEBI:85471;
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC       step 3/10.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AE000666; AAB85880.1; -; Genomic_DNA.
DR   PIR; H69053; H69053.
DR   RefSeq; WP_010877015.1; NC_000916.1.
DR   AlphaFoldDB; O27454; -.
DR   SMR; O27454; -.
DR   STRING; 187420.MTH_1403; -.
DR   EnsemblBacteria; AAB85880; AAB85880; MTH_1403.
DR   GeneID; 1471120; -.
DR   KEGG; mth:MTH_1403; -.
DR   PATRIC; fig|187420.15.peg.1368; -.
DR   HOGENOM; CLU_047948_0_0_2; -.
DR   OMA; VWDDRMV; -.
DR   UniPathway; UPA00148; UER00225.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR   Gene3D; 3.30.950.10; -; 1.
DR   Gene3D; 3.40.1010.10; -; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR   InterPro; IPR007212; Zf-like.
DR   Pfam; PF00590; TP_methylase; 1.
DR   Pfam; PF04071; zf-like; 1.
DR   SUPFAM; SSF53790; SSF53790; 1.
DR   TIGRFAMs; TIGR01466; cobJ_cbiH; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis; Methyltransferase; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..351
FT                   /note="Probable cobalt-factor III C(17)-methyltransferase"
FT                   /id="PRO_0000150404"
SQ   SEQUENCE   351 AA;  38996 MW;  AA80663E252EC541 CRC64;
     MIRIIGIGPA RDDITIRALR ALEDSDVVIG YARYIRQIED LLDGKEVIRS GMGDEIERVE
     LAIEKHREGL DVALVSSGDP GVYGMANVFF QIFDKYSGIE FEVIPGVTAV NYAASKLGAP
     LHDFAVISLS DILTPLSEIM AKIRAAAESG MIIALYNPLG KRRKRPFREA VEILRSLLPP
     QTPVGIVRTV DGAPDVRIVD LESLDESLVD MSTIVLVGNV TTYTRDGQMI TPRGYAVETP
     LHELAREFYE ENPLGKASGP DENCEFYPCH FEGQNCAFCY CPFYPCAEGS TGGRWIRDRG
     VWSCQDCTWI HTDSAVECVK RSLGDIISGP DDLMDKKREL LKLRRECLMR G