ID   CBIH_SALTY              Reviewed;         241 AA.
AC   Q05590;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Probable cobalt-factor III C(17)-methyltransferase;
DE            EC=2.1.1.-;
DE   AltName: Full=Cobalt-precorrin-3 methyltransferase;
DE            Short=Cobalt-precorrin-3 methylase;
GN   Name=cbiH; OrderedLocusNames=STM2027;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF N-TERMINUS.
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=8501034; DOI=10.1128/jb.175.11.3303-3316.1993;
RA   Roth J.R., Lawrence J.G., Rubenfield M., Kieffer-Higgins S., Church G.M.;
RT   "Characterization of the cobalamin (vitamin B12) biosynthetic genes of
RT   Salmonella typhimurium.";
RL   J. Bacteriol. 175:3303-3316(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-10.
RX   PubMed=1451790; DOI=10.1016/0014-5793(92)80213-z;
RA   Roessner C.A., Warren M.J., Santander P.J., Atshaves B.P., Ozaki S.,
RA   Stolowich N.J., Iida K., Scott A.I.;
RT   "Expression of 9 Salmonella typhimurium enzymes for cobinamide synthesis.
RT   Identification of the 11-methyl and 20-methyl transferases of corrin
RT   biosynthesis.";
RL   FEBS Lett. 301:73-78(1992).
RN   [4]
RP   FUNCTION.
RX   PubMed=16198574; DOI=10.1016/j.bmc.2005.08.062;
RA   Santander P.J., Kajiwara Y., Williams H.J., Scott A.I.;
RT   "Structural characterization of novel cobalt corrinoids synthesized by
RT   enzymes of the vitamin B12 anaerobic pathway.";
RL   Bioorg. Med. Chem. 14:724-731(2006).
CC   -!- FUNCTION: Methyltransferase that likely catalyzes the ring contraction
CC       and methylation of C-17 in cobalt-factor III to form cobalt-factor IV.
CC       May also convert cobalt-precorrin-3 to cobalt-precorrin-4.
CC       {ECO:0000269|PubMed:16198574}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co(II)-factor III + H(+) + S-adenosyl-L-methionine = Co(II)-
CC         factor IV + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:45852,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:73299, ChEBI:CHEBI:85471;
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC       step 3/10.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; L12006; AAA27260.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20931.1; -; Genomic_DNA.
DR   RefSeq; NP_460972.1; NC_003197.2.
DR   RefSeq; WP_000953646.1; NC_003197.2.
DR   AlphaFoldDB; Q05590; -.
DR   SMR; Q05590; -.
DR   STRING; 99287.STM2027; -.
DR   PaxDb; Q05590; -.
DR   EnsemblBacteria; AAL20931; AAL20931; STM2027.
DR   GeneID; 1253548; -.
DR   KEGG; stm:STM2027; -.
DR   PATRIC; fig|99287.12.peg.2149; -.
DR   HOGENOM; CLU_047948_2_0_6; -.
DR   OMA; VWDDRMV; -.
DR   PhylomeDB; Q05590; -.
DR   BioCyc; MetaCyc:MON-13222; -.
DR   BioCyc; SENT99287:STM2027-MON; -.
DR   UniPathway; UPA00148; UER00225.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR   Gene3D; 3.30.950.10; -; 1.
DR   Gene3D; 3.40.1010.10; -; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF53790; SSF53790; 1.
DR   TIGRFAMs; TIGR01466; cobJ_cbiH; 1.
PE   1: Evidence at protein level;
KW   Cobalamin biosynthesis; Direct protein sequencing; Methyltransferase;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..241
FT                   /note="Probable cobalt-factor III C(17)-methyltransferase"
FT                   /id="PRO_0000150401"
SQ   SEQUENCE   241 AA;  25869 MW;  36A518CD917FBA33 CRC64;
     MLSVIGIGPG SQAMMTMEAI EALQAAEIVV GYKTYTHLVK AFTGDKQVIK TGMCREIERC
     QAAIELAQAG HNVALISSGD AGIYGMAGLV LELVSKQKLD VEVRLIPGMT ASIAAASLLG
     APLMHDFCHI SLSDLLTPWP VIEKRIVAAG EADFVICFYN PRSRGREGHL ARAFDLLAAS
     KSAQTPVGVV KSAGRKKEEK WLTTLGDMDF EPVDMTSLVI VGNKTTYVQD GLMITPRGYT
     L