YJ2D_SCHPO
ID YJ2D_SCHPO Reviewed; 539 AA.
AC Q9USK3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Uncharacterized transporter C4B3.13;
GN ORFNames=SPCC4B3.13;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:16823372};
CC Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; CU329672; CAB60687.1; -; Genomic_DNA.
DR PIR; T50435; T50435.
DR RefSeq; NP_588077.1; NM_001023069.2.
DR AlphaFoldDB; Q9USK3; -.
DR SMR; Q9USK3; -.
DR BioGRID; 276023; 13.
DR STRING; 284812.Q9USK3; -.
DR iPTMnet; Q9USK3; -.
DR MaxQB; Q9USK3; -.
DR PaxDb; Q9USK3; -.
DR EnsemblFungi; SPCC4B3.13.1; SPCC4B3.13.1:pep; SPCC4B3.13.
DR GeneID; 2539460; -.
DR KEGG; spo:SPCC4B3.13; -.
DR PomBase; SPCC4B3.13; -.
DR VEuPathDB; FungiDB:SPCC4B3.13; -.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_2_1; -.
DR InParanoid; Q9USK3; -.
DR OMA; TGNQKVG; -.
DR PhylomeDB; Q9USK3; -.
DR Reactome; R-SPO-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR PRO; PR:Q9USK3; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0000329; C:fungal-type vacuole membrane; HDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix; Vacuole.
FT CHAIN 1..539
FT /note="Uncharacterized transporter C4B3.13"
FT /id="PRO_0000316589"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 434..454
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 470..490
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 496..516
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 34..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 58828 MW; 3B064DB155232CFA CRC64;
MEGENDPLLG SYKPKRRRSS LVYGLSRPQF LDTAASEVSP IPQERPTTSL RKPTPRVQRP
ATDVSYGALE ETEENESIAS GLSVQEDFNS KAWWKELTLL IKFATPVVLT SLLQYGEVVT
TVFSLGHLGK TELAAASLSN MTATITAFAI YQGIVSALDT VGTQSFGSGN YEMVGLHLQR
ILAILLLIQF PIFLIWWKIE GILLFLRQDP LTCMFAAKYM RVMMLASPAY ALFEALKRFL
QVQGIFHPVT YILAIVVPIN IFLNYLFVWS PWVGFGFLGA PVAVALTLWS ACAVLIIYIM
KVNGRQAWGG FSREALKNWG PLCRLAVPGV IMICSEYWAF ELVTFASGVL GTTELASMSV
LSTTSTLSYN LAFGVAAAAA TRVGNLIGAG NTKLAKLATH VSINLGAAIG VIIAVILFLT
RNTWTYIFTS DKDVVALVAT IIPLVALINI ADNTQCVAGG LLRGQGRQRI GGVVNFIAYY
LLGLPVAIIL CFKLDWGLYG LWIGIGAAIL IIAGVETWCS LHVNWDHLVE LANRQFDEA
