ID   CBIJ_SALTY              Reviewed;         263 AA.
AC   Q05591;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Cobalt-precorrin-6A reductase;
DE            EC=1.3.1.106;
GN   Name=cbiJ; OrderedLocusNames=STM2026;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=8501034; DOI=10.1128/jb.175.11.3303-3316.1993;
RA   Roth J.R., Lawrence J.G., Rubenfield M., Kieffer-Higgins S., Church G.M.;
RT   "Characterization of the cobalamin (vitamin B12) biosynthetic genes of
RT   Salmonella typhimurium.";
RL   J. Bacteriol. 175:3303-3316(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Catalyzes the reduction of the macrocycle of cobalt-
CC       precorrin-6A to cobalt-precorrin-6B. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Co-precorrin-6B + NAD(+) = Co-precorrin-6A + H(+) + NADH;
CC         Xref=Rhea:RHEA:15625, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:60064, ChEBI:CHEBI:72780;
CC         EC=1.3.1.106;
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC       step 7/10.
CC   -!- SIMILARITY: Belongs to the precorrin-6x reductase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00356}.
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DR   EMBL; L12006; AAA27261.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20930.1; -; Genomic_DNA.
DR   RefSeq; NP_460971.1; NC_003197.2.
DR   RefSeq; WP_001001975.1; NC_003197.2.
DR   AlphaFoldDB; Q05591; -.
DR   SMR; Q05591; -.
DR   STRING; 99287.STM2026; -.
DR   PaxDb; Q05591; -.
DR   EnsemblBacteria; AAL20930; AAL20930; STM2026.
DR   GeneID; 1253547; -.
DR   KEGG; stm:STM2026; -.
DR   PATRIC; fig|99287.12.peg.2148; -.
DR   HOGENOM; CLU_068627_0_0_6; -.
DR   OMA; THPYAAQ; -.
DR   PhylomeDB; Q05591; -.
DR   BioCyc; MetaCyc:MON-13224; -.
DR   BioCyc; SENT99287:STM2026-MON; -.
DR   UniPathway; UPA00148; UER00228.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0016994; F:precorrin-6A reductase activity; IEA:InterPro.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR003723; Precorrin-6x_reduct.
DR   PANTHER; PTHR36925; PTHR36925; 1.
DR   Pfam; PF02571; CbiJ; 1.
DR   TIGRFAMs; TIGR00715; precor6x_red; 1.
DR   PROSITE; PS51014; COBK_CBIJ; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..263
FT                   /note="Cobalt-precorrin-6A reductase"
FT                   /id="PRO_0000135915"
SQ   SEQUENCE   263 AA;  28403 MW;  79E8A4FC5967031C CRC64;
     MNEGDVLVVG GTSDARALCR QLDAANVAYT LSVATPAGKA LAGDIKGQVR CGRLEYGQMV
     AWLKENRTRW VIDASHPYAE MVSHNLLRAC ETAGVLLSRY QRPEQLSNLT HPLLYTARSI
     ADACEIARRF GPRVLLTTGS KDLAVWRAGL AEKTLLARVL PVAEVIQRCS ELGFGVGEIF
     ALCGPFSADF NAAFYHQCRA DVVITKASGA EGGYQEKVQP CLDAGIPCIV IARPTPLVTG
     DELLESQAAF AQRLSRWLAA AKE