YJCE_ECOLI
ID YJCE_ECOLI Reviewed; 549 AA.
AC P32703; Q2M6N9;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Uncharacterized Na(+)/H(+) exchanger YjcE;
GN Name=yjcE; OrderedLocusNames=b4065, JW4026;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8265357; DOI=10.1093/nar/21.23.5408;
RA Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.;
RT "Analysis of the Escherichia coli genome. IV. DNA sequence of the region
RT from 89.2 to 92.8 minutes.";
RL Nucleic Acids Res. 21:5408-5417(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000305}.
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DR EMBL; U00006; AAC43159.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77035.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78067.1; -; Genomic_DNA.
DR PIR; H65214; H65214.
DR RefSeq; NP_418489.1; NC_000913.3.
DR RefSeq; WP_000402210.1; NZ_LN832404.1.
DR AlphaFoldDB; P32703; -.
DR SMR; P32703; -.
DR BioGRID; 4262673; 289.
DR STRING; 511145.b4065; -.
DR TCDB; 2.A.36.3.1; the monovalent cation:proton antiporter-1 (cpa1) family.
DR jPOST; P32703; -.
DR PaxDb; P32703; -.
DR PRIDE; P32703; -.
DR EnsemblBacteria; AAC77035; AAC77035; b4065.
DR EnsemblBacteria; BAE78067; BAE78067; BAE78067.
DR GeneID; 948577; -.
DR KEGG; ecj:JW4026; -.
DR KEGG; eco:b4065; -.
DR PATRIC; fig|1411691.4.peg.2639; -.
DR EchoBASE; EB1884; -.
DR eggNOG; COG0025; Bacteria.
DR HOGENOM; CLU_005912_6_3_6; -.
DR InParanoid; P32703; -.
DR OMA; TPPFWAS; -.
DR PhylomeDB; P32703; -.
DR BioCyc; EcoCyc:YJCE-MON; -.
DR PRO; PR:P32703; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015386; F:potassium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR GO; GO:0098719; P:sodium ion import across plasma membrane; IBA:GO_Central.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR PANTHER; PTHR10110; PTHR10110; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR TIGRFAMs; TIGR00831; a_cpa1; 1.
PE 3: Inferred from homology;
KW Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..549
FT /note="Uncharacterized Na(+)/H(+) exchanger YjcE"
FT /id="PRO_0000052399"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 549 AA; 60523 MW; 6F317CF098117DC3 CRC64;
MEIFFTILIM TLVVSLSGVV TRVMPFQIPL PLMQIAIGAL LAWPTFGLHV EFDPELFLVL
FIPPLLFADG WKTPTREFLE HGREIFGLAL ALVVVTVVGI GFLIYWVVPG IPLIPAFALA
AVLSPTDAVA LSGIVGEGRI PKKIMGILQG EALMNDASGL VSLKFAVAVA MGTMIFTVGG
ATVEFMKVAI GGILAGFVVS WLYGRSLRFL SRWGGDEPAT QIVLLFLLPF ASYLIAEHIG
VSGILAAVAA GMTITRSGVM RRAPLAMRLR ANSTWAMLEF VFNGMVFLLL GLQLPGILET
SLMAAEIDPN VEIWMLFTNI ILIYAALMLV RFGWLWTMKK FSNRFLKKKP MEFGSWTTRE
ILIASFAGVR GAITLAGVLS IPLLLPDGNV FPARYELVFL AAGVILFSLF VGVVMLPILL
QHIEVADHSQ QLKEERIARA ATAEVAIVAI QKMEERLAAD TEENIDNQLL TEVSSRVIGN
LRRRADGRND VESSVQEENL ERRFRLAALR SERAELYHLR ATREISNETL QKLLHDLDLL
EALLIEENQ
