YJEM_ECOLI
ID YJEM_ECOLI Reviewed; 500 AA.
AC P39282; Q2M6E6;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Inner membrane transporter YjeM;
GN Name=yjeM; OrderedLocusNames=b4156, JW5739;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA97055.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U14003; AAA97055.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC77116.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE78160.1; -; Genomic_DNA.
DR PIR; S56384; S56384.
DR RefSeq; NP_418580.2; NC_000913.3.
DR RefSeq; WP_001336293.1; NZ_LN832404.1.
DR AlphaFoldDB; P39282; -.
DR SMR; P39282; -.
DR BioGRID; 4260878; 292.
DR STRING; 511145.b4156; -.
DR TCDB; 2.A.3.7.5; the amino acid-polyamine-organocation (apc) family.
DR PaxDb; P39282; -.
DR PRIDE; P39282; -.
DR EnsemblBacteria; AAC77116; AAC77116; b4156.
DR EnsemblBacteria; BAE78160; BAE78160; BAE78160.
DR GeneID; 948679; -.
DR KEGG; ecj:JW5739; -.
DR KEGG; eco:b4156; -.
DR PATRIC; fig|511145.12.peg.4290; -.
DR EchoBASE; EB2368; -.
DR eggNOG; COG0531; Bacteria.
DR HOGENOM; CLU_020854_2_1_6; -.
DR InParanoid; P39282; -.
DR OMA; FMWFASY; -.
DR PhylomeDB; P39282; -.
DR BioCyc; EcoCyc:YJEM-MON; -.
DR PRO; PR:P39282; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR InterPro; IPR002293; AA/rel_permease1.
DR Pfam; PF13520; AA_permease_2; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..500
FT /note="Inner membrane transporter YjeM"
FT /id="PRO_0000213046"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..37
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..132
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..163
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..209
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..319
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 341..369
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 391..394
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 416..433
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 434..454
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 455..462
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 463..483
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 484..500
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 500 AA; 54725 MW; 9B32EBFBD20A1AB4 CRC64;
MPHTIKKMSL IGLILMIFTS VFGFANSPSA YYLMGYSAIP FYIFSALLFF IPFALMMAEM
GAAYRKEEGG IYSWMNNSVG PRFAFIGTFM WFSSYIIWMV STSAKVWVPF STFLYGSDMT
QHWRIAGLEP TQVVGLLAVA WMILVTVVAS KGINKIARIT AVGGIAVMCL NLVLLLVSIT
ILLLNGGHFA QDINFLASPN PGYQSGLAML SFVVFAIFAY GGIEAVGGLV DKTENPEKNF
AKGIVFAAIV ISIGYSLAIF LWGVSTNWQQ VLSNGSVNLG NITYVLMKSL GMTLGNALHL
SPEASLSLGV WFARITGLSM FLAYTGAFFT LCYSPLKAII QGTPKALWPE PMTRLNAMGM
PSIAMWMQCG LVTVFILLVS FGGGTASAFF NKLTLMANVS MTLPYLFLAL AFPFFKARQD
LDRPFVIFKT HLSAMIATVV VVLVVTFANV FTIIQPVVEA GDWDSTLWMI GGPVFFSLLA
MAIYQNYCSR VAKNPQWAVE
