ID   CBIMQ_METLZ             Reviewed;         599 AA.
AC   A2SSD6;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Putative fused cobalt transport protein CbiMQ;
DE   AltName: Full=Energy-coupling factor transporter probable substrate-capture protein CbiMQ;
DE            Short=ECF transporter S component CbiMQ;
GN   Name=cbiMQ; OrderedLocusNames=Mlab_1073;
OS   Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanocorpusculaceae; Methanocorpusculum.
OX   NCBI_TaxID=410358;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43576 / DSM 4855 / Z;
RX   PubMed=21304657; DOI=10.4056/sigs.35575;
RA   Anderson I.J., Sieprawska-Lupa M., Goltsman E., Lapidus A., Copeland A.,
RA   Glavina Del Rio T., Tice H., Dalin E., Barry K., Pitluck S., Hauser L.,
RA   Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.;
RT   "Complete genome sequence of Methanocorpusculum labreanum type strain Z.";
RL   Stand. Genomic Sci. 1:197-203(2009).
CC   -!- FUNCTION: Part of the energy-coupling factor (ECF) transporter complex
CC       CbiMNOQ involved in cobalt import. {ECO:0000250}.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC   -!- SUBUNIT: Forms an energy-coupling factor (ECF) transporter complex
CC       composed of an ATP-binding protein (A component, CbiO), a transmembrane
CC       protein (T component, CbiQ) and 2 possible substrate-capture proteins
CC       (S components, CbiM and CbiN) of unknown stoichimetry. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the CbiM family.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the CbiQ family.
CC       {ECO:0000305}.
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DR   EMBL; CP000559; ABN07242.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2SSD6; -.
DR   SMR; A2SSD6; -.
DR   STRING; 410358.Mlab_1073; -.
DR   EnsemblBacteria; ABN07242; ABN07242; Mlab_1073.
DR   KEGG; mla:Mlab_1073; -.
DR   eggNOG; arCOG02248; Archaea.
DR   eggNOG; arCOG02249; Archaea.
DR   HOGENOM; CLU_455368_0_0_2; -.
DR   OMA; TICYHAN; -.
DR   UniPathway; UPA00148; -.
DR   Proteomes; UP000000365; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0015087; F:cobalt ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01462; CbiM; 1.
DR   InterPro; IPR003339; ABC/ECF_trnsptr_transmembrane.
DR   InterPro; IPR018024; CbiM.
DR   InterPro; IPR002751; CbiM/NikMN.
DR   InterPro; IPR012809; ECF_CbiQ.
DR   PANTHER; PTHR43627; PTHR43627; 1.
DR   Pfam; PF01891; CbiM; 1.
DR   Pfam; PF02361; CbiQ; 1.
DR   TIGRFAMs; TIGR00123; cbiM; 1.
DR   TIGRFAMs; TIGR02454; ECF_T_CbiQ; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cobalamin biosynthesis; Cobalt; Cobalt transport;
KW   Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..599
FT                   /note="Putative fused cobalt transport protein CbiMQ"
FT                   /id="PRO_0000411157"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        438..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        493..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        579..599
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..239
FT                   /note="CbiM"
FT   REGION          341..599
FT                   /note="CbiQ"
SQ   SEQUENCE   599 AA;  64564 MW;  861A6F5D4E029874 CRC64;
     MHIMEGFLPS PWWQFWALLA VVCVLAGMAA LIRLVKRNPE SLPLLGLAGA CVFILSSLKL
     PSVGSSSHAT GTGFGAILFG PAVCSVFCTI VLVFQALLLA HGGITTLGAN IISMGVAGPL
     AACIIFKIGH LIRPEFSIRS FSVTVFCAAA AADLVTYMMT SLQLALAYPA AEGGVLASFV
     VYLGIFSITQ VPLAVLEGIL IVLMMRFVIR IRPDIFVSLD ILSKKETRIL LPSSDQNLSP
     ISKNKWIIAG IIVVLLTASL AFLLAGLGLQ SGSDDLVAET LIDLGNLPVF DPLNLVSEDM
     HGWLFALQAG IGAAVLVFCL YLLRIRSASR GFGKKPHTIF DEHILDDVAI ASPLRQVSAW
     LKLLFCLSAI IIGVTSPLPY LPLFIAGVMI FAALIIAKVS PRLYGSLLTI PLVFAGTGAA
     VILLITGGGE TLIDFFRIGA FHFQITTTSL ELAALVLSRT LAGMCSLYFL TLTTPITSLF
     SVLQKMRMPQ AFIDLSMLIY RYIFVFIGEA IAIHNAQIMR GGYGTWKNYL TSFSMLASML
     FIRTWEKGEA IFVSMDSRCY DGCMALPEEE GHVTPLSAMA VFLFIALIFG LLCAEMLLL