ID   YJEN3_DANRE             Reviewed;         246 AA.
AC   Q1LVI2;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=YjeF N-terminal domain-containing 3;
DE   AltName: Full=ApoA-I-binding protein 2 {ECO:0000303|PubMed:30705153};
GN   Name=yjefn3 {ECO:0000312|ZFIN:ZDB-GENE-050208-755};
GN   Synonyms=aibp2 {ECO:0000303|PubMed:30705153};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   FUNCTION, DEVELOPMENTAL STAGE, INTERACTION WITH APOA1, BINDS TO HDL, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=23719382; DOI=10.1038/nature12166;
RA   Fang L., Choi S.H., Baek J.S., Liu C., Almazan F., Ulrich F., Wiesner P.,
RA   Taleb A., Deer E., Pattison J., Torres-Vazquez J., Li A.C., Miller Y.I.;
RT   "Control of angiogenesis by AIBP-mediated cholesterol efflux.";
RL   Nature 498:118-122(2013).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=30705153; DOI=10.1126/science.aav1749;
RA   Gu Q., Yang X., Lv J., Zhang J., Xia B., Kim J.D., Wang R., Xiong F.,
RA   Meng S., Clements T.P., Tandon B., Wagner D.S., Diaz M.F., Wenzel P.L.,
RA   Miller Y.I., Traver D., Cooke J.P., Li W., Zon L.I., Chen K., Bai Y.,
RA   Fang L.;
RT   "AIBP-mediated cholesterol efflux instructs hematopoietic stem and
RT   progenitor cell fate.";
RL   Science 363:1085-1088(2019).
CC   -!- FUNCTION: Accelerates cholesterol efflux from endothelial cells to
CC       high-density lipoprotein (HDL) and thereby regulates angiogenesis
CC       (PubMed:23719382). Orchestrates hematopoietic stem and progenitor cell
CC       emergence from the hemogenic endothelium, a type of specialized
CC       endothelium manifesting hematopoietic potential. YJEFN3-mediated
CC       cholesterol efflux activates endothelial SREBF2, the master
CC       transcription factor for cholesterol biosynthesis, which in turn
CC       transactivates NOTCH and promotes hematopoietic stem and progenitor
CC       cell emergence (PubMed:30705153). {ECO:0000269|PubMed:23719382,
CC       ECO:0000269|PubMed:30705153}.
CC   -!- SUBUNIT: Interacts with APOA1 (PubMed:23719382). Binds to HDL
CC       (PubMed:23719382). {ECO:0000269|PubMed:23719382}.
CC   -!- DEVELOPMENTAL STAGE: Expression in 24-36 hours post-fertilization (hpf)
CC       embryos shows a clear segmental pattern. By 48 hpf, when segmental
CC       angiogenesis is completed, is no longer expressed in somites.
CC       {ECO:0000269|PubMed:23719382}.
CC   -!- DISRUPTION PHENOTYPE: Mutants appear morphologically normal and have no
CC       observable effect on dorsal aorta specification (PubMed:30705153).
CC       Mutants have reduced the number of nascent hematopoietic stem cells in
CC       the ventral dorsal aorta between 28 and 60 hours post-fertilization
CC       (hpf) (PubMed:30705153). Mutant embryos show increased cholesterol
CC       content (PubMed:30705153, PubMed:23719382).
CC       {ECO:0000269|PubMed:23719382, ECO:0000269|PubMed:30705153}.
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DR   EMBL; BX649279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX664610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001038308.1; NM_001044843.1.
DR   AlphaFoldDB; Q1LVI2; -.
DR   SMR; Q1LVI2; -.
DR   STRING; 7955.ENSDARP00000082703; -.
DR   PaxDb; Q1LVI2; -.
DR   Ensembl; ENSDART00000088270; ENSDARP00000082703; ENSDARG00000061692.
DR   GeneID; 557840; -.
DR   KEGG; dre:557840; -.
DR   CTD; 374887; -.
DR   ZFIN; ZDB-GENE-050208-755; yjefn3.
DR   eggNOG; KOG2585; Eukaryota.
DR   GeneTree; ENSGT00390000007227; -.
DR   HOGENOM; CLU_024853_3_0_1; -.
DR   InParanoid; Q1LVI2; -.
DR   OMA; NIKEPYP; -.
DR   OrthoDB; 1030667at2759; -.
DR   PhylomeDB; Q1LVI2; -.
DR   TreeFam; TF300197; -.
DR   PRO; PR:Q1LVI2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 22.
DR   Bgee; ENSDARG00000061692; Expressed in brain and 12 other tissues.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0052856; F:NADHX epimerase activity; IBA:GO_Central.
DR   GO; GO:0071425; P:hematopoietic stem cell proliferation; IMP:UniProtKB.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0031580; P:membrane raft distribution; IMP:ZFIN.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IMP:ZFIN.
DR   GO; GO:0010874; P:regulation of cholesterol efflux; IMP:UniProtKB.
DR   GO; GO:0008593; P:regulation of Notch signaling pathway; IMP:UniProtKB.
DR   GO; GO:0002040; P:sprouting angiogenesis; IMP:ZFIN.
DR   Gene3D; 3.40.50.10260; -; 1.
DR   InterPro; IPR004443; YjeF_N_dom.
DR   InterPro; IPR036652; YjeF_N_dom_sf.
DR   InterPro; IPR032976; YJEFN_prot_NAXE-like.
DR   PANTHER; PTHR13232; PTHR13232; 1.
DR   Pfam; PF03853; YjeF_N; 1.
DR   SUPFAM; SSF64153; SSF64153; 1.
DR   TIGRFAMs; TIGR00197; yjeF_nterm; 1.
DR   PROSITE; PS51385; YJEF_N; 1.
PE   1: Evidence at protein level;
KW   Lipid transport; Reference proteome; Transport.
FT   CHAIN           1..246
FT                   /note="YjeF N-terminal domain-containing 3"
FT                   /id="PRO_0000450455"
FT   DOMAIN          24..234
FT                   /note="YjeF N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00719"
SQ   SEQUENCE   246 AA;  27609 MW;  AD6F399AAB25EE3D CRC64;
     MNHSSNEKEP ETIEPLRYLS KTEVATVETE LLRDYRFGQQ QLIEIWGHAC AIAITKAFPL
     SSLSKKQPTL LVVCGPEQNG SIGLVCARHL RMFEYEPTIF YPKRSTLGLH QDFTVQCEKM
     DIPFLSYLPT EVQLLNDAYN LVIDAILGPE TDHKDVKEPY AGMLVTLKQV KIPIVSVDVP
     SGWDADEPAK DGINPEVLIS LTAPKKCATG FSGKHFLAGR FLPYDIQKKY ELNLPEFPGT
     ECIIEL