YJEN3_MOUSE
ID YJEN3_MOUSE Reviewed; 251 AA.
AC F6W8I0; J3QM68; Q8R2K0;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2013, sequence version 2.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=YjeF N-terminal domain-containing protein 3 {ECO:0000305};
DE Short=YjeF_N3;
DE Short=hYjeF_N3;
DE AltName: Full=ApoA-I-binding protein 2 {ECO:0000250|UniProtKB:Q1LVI2};
GN Name=Yjefn3 {ECO:0000312|MGI:MGI:2681845};
GN Synonyms=Aibp2 {ECO:0000250|UniProtKB:Q1LVI2};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-192.
RC STRAIN=C57BL/6J;
RX PubMed=8889548; DOI=10.1101/gr.6.9.791;
RA Bonaldo M.F., Lennon G., Soares M.B.;
RT "Normalization and subtraction: two approaches to facilitate gene
RT discovery.";
RL Genome Res. 6:791-806(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-251.
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May accelerate cholesterol efflux from endothelial cells to
CC high-density lipoprotein (HDL) and thereby regulates angiogenesis. May
CC orchestrate hematopoietic stem and progenitor cell emergence from the
CC hemogenic endothelium, a type of specialized endothelium manifesting
CC hematopoietic potential. YJEFN3-mediated cholesterol efflux activates
CC endothelial SREBF2, the master transcription factor for cholesterol
CC biosynthesis, which in turn transactivates NOTCH and promotes
CC hematopoietic stem and progenitor cell emergence (By similarity). May
CC play a role in spermiogenesis and oogenesis (By similarity).
CC {ECO:0000250|UniProtKB:A6XGL0, ECO:0000250|UniProtKB:Q1LVI2}.
CC -!- SUBUNIT: Interacts with APOA1 (By similarity). Binds to HDL (By
CC similarity). {ECO:0000250|UniProtKB:A6XGL0,
CC ECO:0000250|UniProtKB:Q1LVI2}.
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DR EMBL; AC158564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AW121687; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC028663; AAH28663.1; -; mRNA.
DR CCDS; CCDS90407.1; -.
DR RefSeq; XP_006509796.1; XM_006509733.3.
DR AlphaFoldDB; F6W8I0; -.
DR SMR; F6W8I0; -.
DR BioGRID; 212001; 8.
DR STRING; 10090.ENSMUSP00000118931; -.
DR PhosphoSitePlus; F6W8I0; -.
DR PaxDb; F6W8I0; -.
DR PRIDE; F6W8I0; -.
DR ProteomicsDB; 299613; -.
DR Ensembl; ENSMUST00000152938; ENSMUSP00000118931; ENSMUSG00000048967.
DR UCSC; uc009lyc.1; mouse.
DR MGI; MGI:2681845; Yjefn3.
DR VEuPathDB; HostDB:ENSMUSG00000048967; -.
DR eggNOG; KOG2585; Eukaryota.
DR GeneTree; ENSGT00390000007227; -.
DR InParanoid; F6W8I0; -.
DR OMA; NIKEPYP; -.
DR OrthoDB; 1030667at2759; -.
DR TreeFam; TF300197; -.
DR BioGRID-ORCS; 67184; 28 hits in 74 CRISPR screens.
DR PRO; PR:F6W8I0; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; F6W8I0; protein.
DR Bgee; ENSMUSG00000048967; Expressed in olfactory bulb and 60 other tissues.
DR ExpressionAtlas; F6W8I0; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0052856; F:NADHX epimerase activity; IBA:GO_Central.
DR GO; GO:0071425; P:hematopoietic stem cell proliferation; ISS:UniProtKB.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0031580; P:membrane raft distribution; ISS:UniProtKB.
DR GO; GO:0016525; P:negative regulation of angiogenesis; ISS:UniProtKB.
DR GO; GO:0010874; P:regulation of cholesterol efflux; ISS:UniProtKB.
DR GO; GO:0008593; P:regulation of Notch signaling pathway; ISS:UniProtKB.
DR GO; GO:0002040; P:sprouting angiogenesis; ISS:UniProtKB.
DR Gene3D; 3.40.50.10260; -; 1.
DR InterPro; IPR004443; YjeF_N_dom.
DR InterPro; IPR036652; YjeF_N_dom_sf.
DR InterPro; IPR032976; YJEFN_prot_NAXE-like.
DR PANTHER; PTHR13232; PTHR13232; 1.
DR Pfam; PF03853; YjeF_N; 1.
DR SUPFAM; SSF64153; SSF64153; 1.
DR TIGRFAMs; TIGR00197; yjeF_nterm; 1.
DR PROSITE; PS51385; YJEF_N; 1.
PE 1: Evidence at protein level;
KW Lipid transport; Reference proteome; Transport.
FT CHAIN 1..251
FT /note="YjeF N-terminal domain-containing protein 3"
FT /id="PRO_0000420888"
FT DOMAIN 26..239
FT /note="YjeF N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00719"
SQ SEQUENCE 251 AA; 27016 MW; 8DF33F87673EA0D9 CRC64;
MSSSVHNNTG PVQLPEERRF LSASEAAALE RELLEEYRFG RQQLVELCGH ASAVAVTKAF
PLPSLSRKQR TVLVVCGPEQ NGAVGLACAR HLRVFEYQPS IFCPARSADA LHRDLTTQCE
KMDIPFLSFL PAEVRLIDDA YGLVVDAVLG PGVRLAEAGG HCARALATLK RLSIPLVSLD
VPSGWDAEAG GDAKDAVQPD VLVSLAAPKS CAGRFSGRLH FVAGRFVPDD VRRKFGLHLP
KYTGTDCVAS L
