YJHB_BACSU
ID YJHB_BACSU Reviewed; 208 AA.
AC C0SPC3; O34488; Q796N8;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Putative ADP-ribose pyrophosphatase YjhB;
DE EC=3.6.1.-;
GN Name=yjhB; OrderedLocusNames=BSU12190;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9579062; DOI=10.1099/00221287-144-4-877;
RA Rivolta C., Soldo B., Lazarevic V., Joris B., Mauel C., Karamata D.;
RT "A 35.7 kb DNA fragment from the Bacillus subtilis chromosome containing a
RT putative 12.3 kb operon involved in hexuronate catabolism and a perfectly
RT symmetrical hypothetical catabolite-responsive element.";
RL Microbiology 144:877-884(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP SEQUENCE REVISION TO N-TERMINUS.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
RN [4]
RP DISRUPTION PHENOTYPE.
RC STRAIN=168;
RX PubMed=12483591; DOI=10.2323/jgam.46.183;
RA Sasaki M., Yonemura Y., Kurusu Y.;
RT "Genetic analysis of Bacillus subtilis mutator genes.";
RL J. Gen. Appl. Microbiol. 46:183-187(2000).
CC -!- FUNCTION: Probably mediates the hydrolysis of some nucleoside
CC diphosphate derivatives. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC -!- DISRUPTION PHENOTYPE: Cells lacking this gene have an unchanged
CC spontaneous mutation frequency, even in triple mutT/yjhB/yvcI
CC disruptions. {ECO:0000269|PubMed:12483591}.
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC46315.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF015825; AAC46315.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL009126; CAB13076.2; -; Genomic_DNA.
DR PIR; H69850; H69850.
DR RefSeq; NP_389101.2; NC_000964.3.
DR RefSeq; WP_010886490.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; C0SPC3; -.
DR SMR; C0SPC3; -.
DR STRING; 224308.BSU12190; -.
DR PaxDb; C0SPC3; -.
DR PRIDE; C0SPC3; -.
DR EnsemblBacteria; CAB13076; CAB13076; BSU_12190.
DR GeneID; 939419; -.
DR KEGG; bsu:BSU12190; -.
DR PATRIC; fig|224308.43.peg.1278; -.
DR eggNOG; COG1051; Bacteria.
DR InParanoid; C0SPC3; -.
DR OMA; TLPGGWC; -.
DR PhylomeDB; C0SPC3; -.
DR BioCyc; BSUB:BSU12190-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR Pfam; PF00293; NUDIX; 1.
DR SUPFAM; SSF55811; SSF55811; 1.
DR PROSITE; PS51462; NUDIX; 1.
PE 3: Inferred from homology;
KW Hydrolase; Magnesium; Manganese; Metal-binding; Reference proteome.
FT CHAIN 1..208
FT /note="Putative ADP-ribose pyrophosphatase YjhB"
FT /id="PRO_0000379973"
FT DOMAIN 69..195
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT MOTIF 100..121
FT /note="Nudix box"
FT BINDING 115
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 119
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
SQ SEQUENCE 208 AA; 23943 MW; 88513F5000FD0F86 CRC64;
MIKVQTKWLE RAQRIRAIAQ AGLAFSKDVY DRERYEELMK LSAEMMADYS EKDIEVITDL
WQGEKGYPTP KADVRGAVFR ENQILLVREK HDELWSLPGG FCEIGLSPAE NVVKEIKEES
GYDTEPSRLL AVLDSHKHSH PPQPYHYYKI FIACSMTDGQ GETGIETNHA AFFPEDRLPP
LSPKRNTPSQ LSMLFDFLRH PDKKTIFD
