YJJB_ECOLI
ID YJJB_ECOLI Reviewed; 157 AA.
AC P0ADD2; P18389; Q2M5V3;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Probable succinate transporter subunit YjjB {ECO:0000255|HAMAP-Rule:MF_01191, ECO:0000305};
GN Name=yjjB {ECO:0000255|HAMAP-Rule:MF_01191};
GN OrderedLocusNames=b4363, JW4327;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=2844800; DOI=10.1016/s0021-9258(18)68149-9;
RA Masai H., Arai K.;
RT "Operon structure of dnaT and dnaC genes essential for normal and stable
RT DNA replication of Escherichia coli chromosome.";
RL J. Biol. Chem. 263:15083-15093(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP IDENTIFICATION BY 2D-GEL.
RX PubMed=9298644; DOI=10.1002/elps.1150180805;
RA VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.;
RT "Escherichia coli proteome analysis using the gene-protein database.";
RL Electrophoresis 18:1243-1251(1997).
RN [6]
RP FUNCTION, SUBUNIT, AND DISRUPTION PHENOTYPE.
RX PubMed=28673128; DOI=10.1080/09168451.2017.1345612;
RA Fukui K., Nanatani K., Hara Y., Yamakami S., Yahagi D., Chinen A.,
RA Tokura M., Abe K.;
RT "Escherichia coli yjjPB genes encode a succinate transporter important for
RT succinate production.";
RL Biosci. Biotechnol. Biochem. 81:1837-1844(2017).
CC -!- FUNCTION: Involved in succinate export with YjjP. Both proteins are
CC required for export (PubMed:28673128). Contributes to succinate
CC production under both aerobic and anaerobic conditions
CC (PubMed:28673128). {ECO:0000269|PubMed:28673128}.
CC -!- SUBUNIT: The transporter is composed of YjjB and YjjP.
CC {ECO:0000255|HAMAP-Rule:MF_01191, ECO:0000269|PubMed:28673128}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01191, ECO:0000305}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_01191}.
CC -!- DISRUPTION PHENOTYPE: Deletion of yjjPB decreases succinate production
CC in E.coli by 70% under anaerobic conditions.
CC {ECO:0000269|PubMed:28673128}.
CC -!- MISCELLANEOUS: YjjPB constitutes a split-type ThrE family transporter.
CC {ECO:0000303|PubMed:28673128}.
CC -!- SIMILARITY: Belongs to the ThrE exporter (TC 2.A.79) family.
CC {ECO:0000255|HAMAP-Rule:MF_01191, ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA23698.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAA97262.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAE78353.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; J04030; AAA23698.1; ALT_INIT; Genomic_DNA.
DR EMBL; U14003; AAA97262.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC77319.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE78353.1; ALT_INIT; Genomic_DNA.
DR PIR; S56590; RMEC14.
DR RefSeq; NP_418783.2; NC_000913.3.
DR RefSeq; WP_000538191.1; NZ_SSUR01000004.1.
DR AlphaFoldDB; P0ADD2; -.
DR BioGRID; 4262775; 229.
DR STRING; 511145.b4363; -.
DR TCDB; 2.A.79.2.1; the threonine/serine exporter (thre) family.
DR PaxDb; P0ADD2; -.
DR PRIDE; P0ADD2; -.
DR EnsemblBacteria; AAC77319; AAC77319; b4363.
DR EnsemblBacteria; BAE78353; BAE78353; BAE78353.
DR GeneID; 948811; -.
DR KEGG; ecj:JW4327; -.
DR KEGG; eco:b4363; -.
DR PATRIC; fig|1411691.4.peg.2323; -.
DR EchoBASE; EB1199; -.
DR eggNOG; COG3610; Bacteria.
DR HOGENOM; CLU_117642_1_0_6; -.
DR InParanoid; P0ADD2; -.
DR OMA; IPIEWAT; -.
DR PhylomeDB; P0ADD2; -.
DR BioCyc; EcoCyc:EG11215-MON; -.
DR PRO; PR:P0ADD2; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0006970; P:response to osmotic stress; IMP:EcoCyc.
DR GO; GO:1901652; P:response to peptide; IMP:EcoCyc.
DR GO; GO:0015744; P:succinate transport; IMP:EcoCyc.
DR HAMAP; MF_01191; YjjB; 1.
DR InterPro; IPR024528; ThrE_2.
DR InterPro; IPR020914; YjjB-like.
DR Pfam; PF12821; ThrE_2; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..157
FT /note="Probable succinate transporter subunit YjjB"
FT /id="PRO_0000169804"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01191"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01191"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01191"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01191"
FT CONFLICT 154..157
FT /note="RPRV -> PLAYKIASLKHTDERQPPLLRVLL (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 157 AA; 17047 MW; 338920F15D68B9BD CRC64;
MGVIEFLLAL AQDMILAAIP AVGFAMVFNV PVRALRWCAL LGSIGHGSRM ILMTSGLNIE
WSTFMASMLV GTIGIQWSRW YLAHPKVFTV AAVIPMFPGI SAYTAMISAV KISQLGYSEP
LMITLLTNFL TASSIVGALS IGLSIPGLWL YRKRPRV
