YJJP_ECOLI
ID YJJP_ECOLI Reviewed; 256 AA.
AC P0ADD5; P39402; Q2M5V2;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Probable succinate transporter subunit YjjP {ECO:0000305};
GN Name=yjjP; OrderedLocusNames=b4364, JW5796;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS], AND SUBCELLULAR LOCATION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [5]
RP INDUCTION.
RC STRAIN=CSH50;
RX PubMed=18055596; DOI=10.1128/jb.01447-07;
RA Stratmann T., Madhusudan S., Schnetz K.;
RT "Regulation of the yjjQ-bglJ operon, encoding LuxR-type transcription
RT factors, and the divergent yjjP gene by H-NS and LeuO.";
RL J. Bacteriol. 190:926-935(2008).
RN [6]
RP OPERON STRUCTURE, AND INDUCTION.
RC STRAIN=K12 / BW25113;
RX PubMed=19429622; DOI=10.1128/jb.00108-09;
RA Shimada T., Yamamoto K., Ishihama A.;
RT "Involvement of the leucine response transcription factor LeuO in
RT regulation of the genes for sulfa drug efflux.";
RL J. Bacteriol. 191:4562-4571(2009).
RN [7]
RP FUNCTION, SUBUNIT, AND DISRUPTION PHENOTYPE.
RX PubMed=28673128; DOI=10.1080/09168451.2017.1345612;
RA Fukui K., Nanatani K., Hara Y., Yamakami S., Yahagi D., Chinen A.,
RA Tokura M., Abe K.;
RT "Escherichia coli yjjPB genes encode a succinate transporter important for
RT succinate production.";
RL Biosci. Biotechnol. Biochem. 81:1837-1844(2017).
CC -!- FUNCTION: Involved in succinate export with YjjB. Both proteins are
CC required for export (PubMed:28673128). Contributes to succinate
CC production under both aerobic and anaerobic conditions
CC (PubMed:28673128). {ECO:0000269|PubMed:28673128}.
CC -!- SUBUNIT: The transporter is composed of YjjB and YjjP.
CC {ECO:0000269|PubMed:28673128}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- INDUCTION: Has 2 promoters, 1 of which is repressed by H-NS. Activated
CC by LeuO. A monocistronic operon. {ECO:0000269|PubMed:18055596,
CC ECO:0000269|PubMed:19429622}.
CC -!- DISRUPTION PHENOTYPE: Deletion of yjjPB decreases succinate production
CC in E.coli by 70% under anaerobic conditions.
CC {ECO:0000269|PubMed:28673128}.
CC -!- MISCELLANEOUS: YjjPB constitutes a split-type ThrE family transporter.
CC {ECO:0000303|PubMed:28673128}.
CC -!- SIMILARITY: Belongs to the ThrE exporter (TC 2.A.79) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA97263.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U14003; AAA97263.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC77320.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE78354.1; -; Genomic_DNA.
DR PIR; S56591; S56591.
DR RefSeq; NP_418784.4; NC_000913.3.
DR RefSeq; WP_001338213.1; NZ_STEB01000025.1.
DR AlphaFoldDB; P0ADD5; -.
DR BioGRID; 4259591; 12.
DR STRING; 511145.b4364; -.
DR TCDB; 2.A.79.2.1; the threonine/serine exporter (thre) family.
DR PaxDb; P0ADD5; -.
DR PRIDE; P0ADD5; -.
DR EnsemblBacteria; AAC77320; AAC77320; b4364.
DR EnsemblBacteria; BAE78354; BAE78354; BAE78354.
DR GeneID; 58389892; -.
DR GeneID; 948812; -.
DR KEGG; ecj:JW5796; -.
DR KEGG; eco:b4364; -.
DR PATRIC; fig|1411691.4.peg.2322; -.
DR EchoBASE; EB2477; -.
DR eggNOG; COG2966; Bacteria.
DR HOGENOM; CLU_070277_2_0_6; -.
DR InParanoid; P0ADD5; -.
DR OMA; ITRLCIQ; -.
DR PhylomeDB; P0ADD5; -.
DR BioCyc; EcoCyc:G7946-MON; -.
DR PRO; PR:P0ADD5; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015744; P:succinate transport; IMP:EcoCyc.
DR InterPro; IPR010619; ThrE.
DR Pfam; PF06738; ThrE; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..256
FT /note="Probable succinate transporter subunit YjjP"
FT /id="PRO_0000169811"
FT TOPO_DOM 1..113
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 114..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..140
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 141..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..194
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..256
FT /note="Periplasmic"
FT /evidence="ECO:0000269|PubMed:15919996"
SQ SEQUENCE 256 AA; 28001 MW; FC7FBE8ED0BE340A CRC64;
MQTEQQRAVT RLCIQCGLFL LQHGAESALV DELSSRLGRA LGMDSVESSI SSNAIVLTTI
KDGQCLTSTR KNHDRGINMH VVTEVQHIVI LAEHHLLDYK GVEKRFSQIQ PLRYPRWLVA
LMVGLSCACF CKLNNGGWDG AVITFFASTT AMYIRQLLAQ RHLHPQINFC LTAFAATTIS
GLLLQLPTFS NTPTIAMAAS VLLLVPGFPL INAVADMFKG HINTGLARWA IASLLTLATC
VGVVMALTIW GLRGWV
