ID   YJJU_ECOLI              Reviewed;         357 AA.
AC   P39407; Q2M5U0;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Uncharacterized protein YjjU;
DE            EC=3.1.1.-;
GN   Name=yjjU; OrderedLocusNames=b4377, JW4340;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA   Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT   "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT   from 92.8 through 100 minutes.";
RL   Nucleic Acids Res. 23:2105-2119(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Probable lipid hydrolase. {ECO:0000250}.
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DR   EMBL; U14003; AAA97273.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC77330.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE78366.1; -; Genomic_DNA.
DR   PIR; S56601; S56601.
DR   RefSeq; NP_418794.1; NC_000913.3.
DR   RefSeq; WP_001299799.1; NZ_STEB01000033.1.
DR   AlphaFoldDB; P39407; -.
DR   SMR; P39407; -.
DR   BioGRID; 4261643; 17.
DR   BioGRID; 853183; 1.
DR   DIP; DIP-6892N; -.
DR   IntAct; P39407; 11.
DR   STRING; 511145.b4377; -.
DR   jPOST; P39407; -.
DR   PaxDb; P39407; -.
DR   PRIDE; P39407; -.
DR   EnsemblBacteria; AAC77330; AAC77330; b4377.
DR   EnsemblBacteria; BAE78366; BAE78366; BAE78366.
DR   GeneID; 948906; -.
DR   KEGG; ecj:JW4340; -.
DR   KEGG; eco:b4377; -.
DR   PATRIC; fig|1411691.4.peg.2310; -.
DR   EchoBASE; EB2482; -.
DR   eggNOG; COG4667; Bacteria.
DR   HOGENOM; CLU_048271_0_1_6; -.
DR   InParanoid; P39407; -.
DR   OMA; DLDWYFD; -.
DR   PhylomeDB; P39407; -.
DR   BioCyc; EcoCyc:G7951-MON; -.
DR   PRO; PR:P39407; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:EcoliWiki.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd07208; Pat_hypo_Ecoli_yjju_like; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR045943; DUF6363.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR037483; YjjU-like.
DR   Pfam; PF19890; DUF6363; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; SSF52151; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome.
FT   CHAIN           1..357
FT                   /note="Uncharacterized protein YjjU"
FT                   /id="PRO_0000169816"
FT   DOMAIN          27..196
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   MOTIF           31..36
FT                   /note="GXGXXG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   MOTIF           59..63
FT                   /note="GXSXG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   MOTIF           183..185
FT                   /note="DGA/G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   ACT_SITE        61
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   ACT_SITE        183
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
SQ   SEQUENCE   357 AA;  39832 MW;  D7A57185B93CCEAA CRC64;
     MGQRIPVTLG NIAPLSLRPF QPGRIALVCE GGGQRGIFTA GVLDEFMRAQ FNPFDLYLGT
     SAGAQNLSAF ICNQPGYARK VIMRYTTKRE FFDPLRFVRG GNLIDLDWLV EATASQMPLQ
     MDTAARLFDS GKSFYMCACR QDDYAPNYFL PTKQNWLDVI RASSAIPGFY RSGVSLEGIN
     YLDGGISDAI PVKEAARQGA KTLVVIRTVP SQMYYTPQWF KRMERWLGDS SLQPLVNLVQ
     HHETSYRDIQ QFIEKPPGKL RIFEIYPPKP LHSIALGSRI PALREDYKLG RLCGRYFLAT
     VGKLLTEKAP LTRHLVPVVT PESIVIPPAP VANDTLVAEV SDAPQANDPT FNNEDLA