YJMD_SCHPO
ID YJMD_SCHPO Reviewed; 669 AA.
AC Q7LKZ6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Probable phospholipase C1020.13c;
DE EC=3.1.1.-;
GN ORFNames=SPCC1020.13c, SPCC14G10.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Probable phospholipase that hydrolyzes phosphatidic acid.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the PA-PLA1 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA20658.1; -; Genomic_DNA.
DR PIR; T40827; T40827.
DR RefSeq; NP_587946.1; NM_001022937.2.
DR AlphaFoldDB; Q7LKZ6; -.
DR STRING; 4896.SPCC1020.13c.1; -.
DR MaxQB; Q7LKZ6; -.
DR PaxDb; Q7LKZ6; -.
DR EnsemblFungi; SPCC1020.13c.1; SPCC1020.13c.1:pep; SPCC1020.13c.
DR GeneID; 2539084; -.
DR KEGG; spo:SPCC1020.13c; -.
DR PomBase; SPCC1020.13c; -.
DR VEuPathDB; FungiDB:SPCC1020.13c; -.
DR eggNOG; KOG2308; Eukaryota.
DR HOGENOM; CLU_002680_0_1_1; -.
DR InParanoid; Q7LKZ6; -.
DR OMA; CGSPVGF; -.
DR PhylomeDB; Q7LKZ6; -.
DR Reactome; R-SPO-1483166; Synthesis of PA.
DR Reactome; R-SPO-1483226; Synthesis of PI.
DR PRO; PR:Q7LKZ6; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004620; F:phospholipase activity; IBA:GO_Central.
DR GO; GO:0044242; P:cellular lipid catabolic process; NAS:PomBase.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004177; DDHD_dom.
DR Pfam; PF02862; DDHD; 1.
DR SMART; SM01127; DDHD; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS51043; DDHD; 1.
DR PROSITE; PS00120; LIPASE_SER; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Hydrolase; Lipid degradation; Lipid metabolism; Nucleus;
KW Reference proteome.
FT CHAIN 1..669
FT /note="Probable phospholipase C1020.13c"
FT /id="PRO_0000316025"
FT DOMAIN 463..644
FT /note="DDHD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00378"
FT ACT_SITE 400
FT /evidence="ECO:0000250"
SQ SEQUENCE 669 AA; 77443 MW; C39DEDF4F5B49295 CRC64;
MQESSQEEPV HYVQWFYLSN YDLYDETSSM ELTGAQSWRR FLNYDNNALE AKYNEIITEE
VSQEPNQKNV IVGISGLHVV NLPTLTLKPL YWPSASKNDT LRVVRGLWMY EDTGLPVINE
LSDMLEEGYQ EVKPYAVNWD NVLKEEEEGK DSQDDPSVLS HKRNKSSKEL IDAMQWPLKP
TSSGKYVFYE DGYRALICQG GLLSYFSKGT QSRRTSIKGM PVVRDFPYFE DDGFNGPKQV
TDLFLVVHGI GQKRSETEER FLFTKTCNVF RSLIQIQKNI MKEDPLIRND YEPQLLPICW
RNKLNFNSYI KPVAGDEGRV EDEEFEENRF SIEDIEIDSI PAVRRLLGDV MSDIPYYMSH
HKESIIKSVI REANRVYHLW KDCNPYFLEN KGRIFIIGHS LGSTVVFDIL SLQPTFVKEI
TIDDDESCFI FDTNGFFCFG GPVGFFLHLN QQSIIPRRGR GSSRYEINKN FINSDVPKSY
TYDGYDRYGC LAVDSFYNIY NHLDPVAMRL NPTVDLSFSK GIHPTRILFT RKSSSILRMI
SHSNTDPVEL RSYNQSLQQN KNNEPTAVVP LEPEQTVELE TRNFRREERA KWRMQELNEN
SQLDYVFTSA HGVISNKYLS MLSAHSSYWS SEDLACFLVV ETGRNFGIAN SIEQFRGKHM
PRIFKGDSS
