YJQ3_YEAST
ID YJQ3_YEAST Reviewed; 555 AA.
AC P46996; D6VW24;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Uncharacterized membrane protein YJL163C;
GN OrderedLocusNames=YJL163C; ORFNames=J0544;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
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DR EMBL; Z49438; CAA89458.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08640.1; -; Genomic_DNA.
DR PIR; S56946; S56946.
DR RefSeq; NP_012372.1; NM_001181596.1.
DR AlphaFoldDB; P46996; -.
DR SMR; P46996; -.
DR BioGRID; 33596; 115.
DR DIP; DIP-8000N; -.
DR STRING; 4932.YJL163C; -.
DR TCDB; 2.A.1.11.4; the major facilitator superfamily (mfs).
DR iPTMnet; P46996; -.
DR PaxDb; P46996; -.
DR PRIDE; P46996; -.
DR EnsemblFungi; YJL163C_mRNA; YJL163C; YJL163C.
DR GeneID; 853276; -.
DR KEGG; sce:YJL163C; -.
DR SGD; S000003699; YJL163C.
DR VEuPathDB; FungiDB:YJL163C; -.
DR eggNOG; KOG2816; Eukaryota.
DR GeneTree; ENSGT00950000183096; -.
DR HOGENOM; CLU_017517_2_1_1; -.
DR InParanoid; P46996; -.
DR OMA; YMFMREQ; -.
DR BioCyc; YEAST:G3O-31603-MON; -.
DR Reactome; R-SCE-196757; Metabolism of folate and pterines.
DR Reactome; R-SCE-917937; Iron uptake and transport.
DR Reactome; R-SCE-9707616; Heme signaling.
DR PRO; PR:P46996; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P46996; protein.
DR GO; GO:0000329; C:fungal-type vacuole membrane; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..555
FT /note="Uncharacterized membrane protein YJL163C"
FT /id="PRO_0000203027"
FT TOPO_DOM 1..83
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..356
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 378..386
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 408..428
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 450..459
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 481..491
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 492..512
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 513..523
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 545..555
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 289..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 61525 MW; A72400A0BB80A533 CRC64;
MSNEDETTRL MSSDEMDYLL ETAGINALEE IISQNDSTGI NLDTNETAQD SSYDSIRRSP
SILSVAKSVE GEHGRRKLLC LYGLVMIICI AESISMTATI PLVMDKVAEG ISDENGHYDS
VAVQTIVSSI SSSTMMIAGA ISIFMAGKWG ELSDRIGRVR VFKYMSGIRV IGLLTHVFTL
SSKMKYHKWA IVLTACIVPS FGGLFALVAN GNSYVSDIVK TEHRMVTIGI MMSCIYATMG
VGPMFGSFLV KWTHGNGFIP IYTSIAFVIL ALIICETIMV EPRHETQMAH SQSTYTKRRE
KLRSQSGSDD ARNYQSVTYG KFQIMRLMDL LAPVKKLWLK PDSAGSLVPR HTVILLIVLD
ILFVCGTTSC MPALILFSTY EYKWHAVELG YFISILGIGR GVVLLVVSPT LLYTLKRIYQ
HLNHSIDKID IFCIQFSMIV ITLSLFVMIR FGEKTPTSMI IFALLQALSA FCSPTLQSGI
IKYTSKKHTG EMFGAMALVR SCVMLVIPPI LLKLYGSTVS VNPSLFMYIP FSTSIVAILL
TFFLRIYKNP PLDGP
