YJT3_YEAST
ID YJT3_YEAST Reviewed; 402 AA.
AC P39542; D6VVZ8;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Uncharacterized transporter YJL193W;
GN OrderedLocusNames=YJL193W; ORFNames=J0349;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7754713; DOI=10.1002/yea.320100912;
RA Purnelle B., Coster F., Goffeau A.;
RT "The sequence of a 36 kb segment on the left arm of yeast chromosome X
RT identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6,
RT CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two
RT homologues to chromosome III genes.";
RL Yeast 10:1235-1249(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the TPT transporter family. {ECO:0000305}.
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DR EMBL; X77688; CAA54767.1; -; Genomic_DNA.
DR EMBL; Z49468; CAA89488.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08614.1; -; Genomic_DNA.
DR PIR; S46641; S46641.
DR RefSeq; NP_012342.1; NM_001181626.1.
DR AlphaFoldDB; P39542; -.
DR BioGRID; 33570; 57.
DR DIP; DIP-7379N; -.
DR IntAct; P39542; 1.
DR MINT; P39542; -.
DR STRING; 4932.YJL193W; -.
DR iPTMnet; P39542; -.
DR MaxQB; P39542; -.
DR PaxDb; P39542; -.
DR PRIDE; P39542; -.
DR EnsemblFungi; YJL193W_mRNA; YJL193W; YJL193W.
DR GeneID; 853246; -.
DR KEGG; sce:YJL193W; -.
DR SGD; S000003729; YJL193W.
DR VEuPathDB; FungiDB:YJL193W; -.
DR eggNOG; KOG1441; Eukaryota.
DR GeneTree; ENSGT00940000159007; -.
DR HOGENOM; CLU_019048_4_1_1; -.
DR InParanoid; P39542; -.
DR OMA; YDKLTLM; -.
DR BioCyc; YEAST:G3O-31625-MON; -.
DR PRO; PR:P39542; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P39542; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0089721; F:phosphoenolpyruvate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1990536; P:phosphoenolpyruvate transmembrane import into Golgi lumen; IBA:GO_Central.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR Pfam; PF03151; TPT; 2.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..402
FT /note="Uncharacterized transporter YJL193W"
FT /id="PRO_0000206786"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..50
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..103
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..134
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..206
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..353
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 375..402
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 402 AA; 45937 MW; 3C8A1C2BFEB70F2A CRC64;
MFQQLSASIR HNAHIIFLCI SWYFISSLAS QVTKQVLTVC PLPLFLGEFQ FIYTAVLAWF
TCYIAYSFPG FYRIFPNGTF PEYYIDDRET SRAARKESKL SSLIIPPSKP ILQTVLPLGL
FQFVGKYFGH TATSLVPVST VASIKTLSPM FILLLQKILK ISTLKITLTL IFSLCTLVLG
VWIIVQEDNR SPASSNELRE FSKYGVICAM ISMFIFVLQN IYGKTVFTYR SQTDESQSNS
GFSRQESPLP LYEKLDEKLV AKKKPKSYDK LTLMIYISLV GFCLSFGWFI TLEFPVLFRY
FFQINSSSTV IKAFPVSLFL LNGTFHFIQA MITFHLLGEV STLTYSIANL MKRFAIIAVS
WVFIGRRITW LQVFGLVLNT LGLFLYERCT SQSKIKAKIR PE
