ID   YJU2B_BOVIN             Reviewed;         400 AA.
AC   Q5EA37; Q5EA21;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Probable splicing factor YJU2B {ECO:0000305};
DE   AltName: Full=Coiled-coil domain-containing protein 130;
GN   Name=YJU2B; Synonyms=CCDC130;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in mRNA splicing.
CC       {ECO:0000250|UniProtKB:Q9BW85}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BW85}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5EA37-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5EA37-2; Sequence=VSP_023517;
CC   -!- SIMILARITY: Belongs to the CWC16 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BT020695; AAX08712.1; -; mRNA.
DR   EMBL; BT020732; AAX08749.1; -; mRNA.
DR   EMBL; BT020748; AAX08765.1; -; mRNA.
DR   EMBL; BC113236; AAI13237.1; -; mRNA.
DR   RefSeq; NP_001069812.1; NM_001076344.1. [Q5EA37-1]
DR   AlphaFoldDB; Q5EA37; -.
DR   SMR; Q5EA37; -.
DR   STRING; 9913.ENSBTAP00000003269; -.
DR   PaxDb; Q5EA37; -.
DR   PRIDE; Q5EA37; -.
DR   Ensembl; ENSBTAT00000003269; ENSBTAP00000003269; ENSBTAG00000002516. [Q5EA37-1]
DR   Ensembl; ENSBTAT00000017226; ENSBTAP00000017226; ENSBTAG00000002516. [Q5EA37-1]
DR   GeneID; 614791; -.
DR   KEGG; bta:614791; -.
DR   CTD; 81576; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002516; -.
DR   eggNOG; KOG2990; Eukaryota.
DR   GeneTree; ENSGT00530000063615; -.
DR   InParanoid; Q5EA37; -.
DR   OMA; RNMSVWD; -.
DR   OrthoDB; 1583452at2759; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000002516; Expressed in laryngeal cartilage and 104 other tissues.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR   GO; GO:0008380; P:RNA splicing; IBA:GO_Central.
DR   InterPro; IPR007590; Saf4/Yju2.
DR   PANTHER; PTHR12111; PTHR12111; 1.
DR   Pfam; PF04502; Saf4_Yju2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..400
FT                   /note="Probable splicing factor YJU2B"
FT                   /id="PRO_0000280045"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          182..214
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        255..293
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..379
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..400
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         40
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P13994"
FT   MOD_RES         310
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P13994"
FT   VAR_SEQ         371..388
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16305752"
FT                   /id="VSP_023517"
FT   CONFLICT        322
FT                   /note="E -> D (in Ref. 1; AAX08765)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   400 AA;  45481 MW;  026869EF4EB78675 CRC64;
     MGERKGVNKY YPPDFNPEKH GSLNRYHNSH PLRERARKLS QGILIIRFEM PYNIWCDGCK
     NHIGMGVRYN AEKKKVGNYY TTPIYRFRMK CHLCVNYIEM QTDPANCDYV IVSGAQRKEE
     RWDMEDNEQV LTTEHEKKQK LEMDAMFRLE HGEADRSTLK KALPTLSHIQ EAQSAWKDDF
     ALNSMLRKRF REKKKAMQEE EERDQALQAK ASLAIPLVPE TEDDRRLAAL LKFHTLDSYE
     DKQKLKRTEI ISRSWFPSTP GASASSSSSS KTNSVLKKLA QNRRATPTSS PVTMGHLGIV
     RRRSREVPES PQHVAETFKS GEPQLPEGTN QNRPVSPQDC SLETAETPKN SSALGQEESC
     QDRPQPPPDT SPEAPNPQDT PQPCSLGSSL VADYSGSESE