ID   YJU2B_HUMAN             Reviewed;         396 AA.
AC   P13994; Q9BQ72;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Probable splicing factor YJU2B {ECO:0000305};
DE   AltName: Full=Coiled-coil domain-containing protein 130 {ECO:0000312|HGNC:HGNC:28118};
GN   Name=YJU2B {ECO:0000312|HGNC:HGNC:28118};
GN   Synonyms=CCDC130 {ECO:0000312|HGNC:HGNC:28118}; ORFNames=SB115;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Wan T., Li N., Zhang W., Cao X.;
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 192-396, AND INDUCTION.
RC   TISSUE=Fibroblast;
RX   PubMed=3203696; DOI=10.1111/j.1432-1033.1988.tb14433.x;
RA   Lammers R., Gross G., Mayr U., Collins J.;
RT   "Alternative mechanisms for gene activation induced by poly(rI).poly(rC)
RT   and Newcastle disease virus.";
RL   Eur. J. Biochem. 178:93-99(1988).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA   Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT   "System-wide temporal characterization of the proteome and phosphoproteome
RT   of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40; SER-306 AND SER-362, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma, and Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: May be involved in mRNA splicing.
CC       {ECO:0000250|UniProtKB:Q9BW85}.
CC   -!- INTERACTION:
CC       P13994; Q92989: CLP1; NbExp=3; IntAct=EBI-716093, EBI-2559831;
CC       P13994; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-716093, EBI-743105;
CC       P13994; O75031: HSF2BP; NbExp=3; IntAct=EBI-716093, EBI-7116203;
CC       P13994; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-716093, EBI-358489;
CC       P13994; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-716093, EBI-3918381;
CC       P13994; Q96NJ6: ZFP3; NbExp=5; IntAct=EBI-716093, EBI-12302147;
CC       P13994; P49910: ZNF165; NbExp=6; IntAct=EBI-716093, EBI-741694;
CC       P13994; P17021: ZNF17; NbExp=3; IntAct=EBI-716093, EBI-1105334;
CC       P13994; P17028: ZNF24; NbExp=7; IntAct=EBI-716093, EBI-707773;
CC       P13994; P15622-3: ZNF250; NbExp=3; IntAct=EBI-716093, EBI-10177272;
CC       P13994; P17036: ZNF3; NbExp=5; IntAct=EBI-716093, EBI-1640965;
CC       P13994; Q86UD4: ZNF329; NbExp=5; IntAct=EBI-716093, EBI-7233259;
CC       P13994; P13682: ZNF35; NbExp=3; IntAct=EBI-716093, EBI-11041653;
CC       P13994; Q7Z3I7: ZNF572; NbExp=9; IntAct=EBI-716093, EBI-10172590;
CC       P13994; Q9UEG4: ZNF629; NbExp=3; IntAct=EBI-716093, EBI-9977294;
CC       P13994; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-716093, EBI-10251462;
CC       P13994; Q15937: ZNF79; NbExp=3; IntAct=EBI-716093, EBI-10237274;
CC       P13994; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-716093, EBI-5667516;
CC       P13994; Q3MJ62: ZSCAN23; NbExp=5; IntAct=EBI-716093, EBI-5667532;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BW85}.
CC   -!- INDUCTION: By poly(RI), poly(RC) and Newcastle disease virus.
CC       {ECO:0000269|PubMed:3203696}.
CC   -!- SIMILARITY: Belongs to the CWC16 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA32138.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAA32138.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF250306; AAK37425.1; -; mRNA.
DR   EMBL; BC002905; AAH02905.1; -; mRNA.
DR   EMBL; X13956; CAA32138.1; ALT_SEQ; Genomic_DNA.
DR   CCDS; CCDS12296.1; -.
DR   PIR; S02660; S02660.
DR   RefSeq; NP_001307490.1; NM_001320561.1.
DR   RefSeq; NP_001307493.1; NM_001320564.1.
DR   RefSeq; NP_001307494.1; NM_001320565.1.
DR   RefSeq; NP_001307495.1; NM_001320566.1.
DR   RefSeq; NP_001307496.1; NM_001320567.1.
DR   RefSeq; NP_001307497.1; NM_001320568.1.
DR   RefSeq; NP_001307498.1; NM_001320569.1.
DR   RefSeq; NP_110445.1; NM_030818.3.
DR   RefSeq; XP_005260143.1; XM_005260086.4.
DR   AlphaFoldDB; P13994; -.
DR   SMR; P13994; -.
DR   BioGRID; 123536; 67.
DR   IntAct; P13994; 33.
DR   MINT; P13994; -.
DR   STRING; 9606.ENSP00000465776; -.
DR   GlyGen; P13994; 1 site.
DR   iPTMnet; P13994; -.
DR   PhosphoSitePlus; P13994; -.
DR   BioMuta; CCDC130; -.
DR   DMDM; 134037158; -.
DR   EPD; P13994; -.
DR   jPOST; P13994; -.
DR   MassIVE; P13994; -.
DR   MaxQB; P13994; -.
DR   PaxDb; P13994; -.
DR   PeptideAtlas; P13994; -.
DR   PRIDE; P13994; -.
DR   ProteomicsDB; 53015; -.
DR   Antibodypedia; 54013; 51 antibodies from 12 providers.
DR   DNASU; 81576; -.
DR   Ensembl; ENST00000221554.13; ENSP00000221554.7; ENSG00000104957.14.
DR   Ensembl; ENST00000586600.5; ENSP00000465776.1; ENSG00000104957.14.
DR   GeneID; 81576; -.
DR   KEGG; hsa:81576; -.
DR   MANE-Select; ENST00000221554.13; ENSP00000221554.7; NM_030818.4; NP_110445.1.
DR   UCSC; uc002mxc.2; human.
DR   CTD; 81576; -.
DR   DisGeNET; 81576; -.
DR   GeneCards; YJU2B; -.
DR   HGNC; HGNC:28118; YJU2B.
DR   HPA; ENSG00000104957; Low tissue specificity.
DR   neXtProt; NX_P13994; -.
DR   OpenTargets; ENSG00000104957; -.
DR   VEuPathDB; HostDB:ENSG00000104957; -.
DR   eggNOG; KOG2990; Eukaryota.
DR   GeneTree; ENSGT00530000063615; -.
DR   HOGENOM; CLU_050402_3_1_1; -.
DR   InParanoid; P13994; -.
DR   OMA; RNMSVWD; -.
DR   OrthoDB; 1583452at2759; -.
DR   PhylomeDB; P13994; -.
DR   PathwayCommons; P13994; -.
DR   SignaLink; P13994; -.
DR   BioGRID-ORCS; 81576; 576 hits in 1086 CRISPR screens.
DR   ChiTaRS; CCDC130; human.
DR   GenomeRNAi; 81576; -.
DR   Pharos; P13994; Tdark.
DR   PRO; PR:P13994; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; P13994; protein.
DR   Bgee; ENSG00000104957; Expressed in granulocyte and 179 other tissues.
DR   ExpressionAtlas; P13994; baseline and differential.
DR   Genevisible; P13994; HS.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   GO; GO:0009615; P:response to virus; IEP:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; IBA:GO_Central.
DR   InterPro; IPR007590; Saf4/Yju2.
DR   PANTHER; PTHR12111; PTHR12111; 1.
DR   Pfam; PF04502; Saf4_Yju2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..396
FT                   /note="Probable splicing factor YJU2B"
FT                   /id="PRO_0000064401"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          295..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          182..214
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        341..396
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         40
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         306
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21406692,
FT                   ECO:0007744|PubMed:23186163"
FT   MOD_RES         362
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VARIANT         22
FT                   /note="S -> C (in dbSNP:rs12974461)"
FT                   /id="VAR_053854"
FT   VARIANT         336
FT                   /note="C -> S (in dbSNP:rs35761244)"
FT                   /id="VAR_053855"
SQ   SEQUENCE   396 AA;  44802 MW;  6D2EA8F4680EF89F CRC64;
     MGERKGVNKY YPPDFNPEKH GSLNRYHNSH PLRERARKLS QGILIIRFEM PYNIWCDGCK
     NHIGMGVRYN AEKKKVGNYY TTPIYRFRMK CHLCVNYIEM QTDPANCDYV IVSGAQRKEE
     RWDMADNEQV LTTEHEKKQK LETDAMFRLE HGEADRSTLK KALPTLSHIQ EAQSAWKDDF
     ALNSMLRRRF REKKKAIQEE EERDQALQAK ASLTIPLVPE TEDDRKLAAL LKFHTLDSYE
     DKQKLKRTEI ISRSWFPSAP GSASSSKVSG VLKKLAQSRR TALATSPITV GDLGIVRRRS
     RDVPESPQHA ADTPKSGEPR VPEEAAQDRP MSPGDCPPET TETPKCSSPR GQEGSRQDKP
     LSPAGSSQEA ADTPDTRHPC SLGSSLVADY SDSESE