YJU2B_MOUSE
ID YJU2B_MOUSE Reviewed; 385 AA.
AC Q9D516; Q8VCB4;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Probable splicing factor YJU2B {ECO:0000305};
DE AltName: Full=Coiled-coil domain-containing protein 130 {ECO:0000312|MGI:MGI:1914986};
GN Name=Yju2b; Synonyms=Ccdc130 {ECO:0000312|MGI:MGI:1914986};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in mRNA splicing.
CC {ECO:0000250|UniProtKB:Q9BW85}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BW85}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D516-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D516-2; Sequence=VSP_023900, VSP_023901;
CC -!- SIMILARITY: Belongs to the CWC16 family. {ECO:0000305}.
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DR EMBL; AK015911; BAB30026.1; -; mRNA.
DR EMBL; BC021321; AAH21321.1; -; mRNA.
DR CCDS; CCDS40409.1; -. [Q9D516-1]
DR CCDS; CCDS80906.1; -. [Q9D516-2]
DR RefSeq; NP_001281210.1; NM_001294281.1. [Q9D516-2]
DR RefSeq; NP_080626.1; NM_026350.3. [Q9D516-1]
DR RefSeq; XP_006531378.1; XM_006531315.3. [Q9D516-1]
DR AlphaFoldDB; Q9D516; -.
DR SMR; Q9D516; -.
DR STRING; 10090.ENSMUSP00000096177; -.
DR iPTMnet; Q9D516; -.
DR PhosphoSitePlus; Q9D516; -.
DR EPD; Q9D516; -.
DR jPOST; Q9D516; -.
DR MaxQB; Q9D516; -.
DR PaxDb; Q9D516; -.
DR PRIDE; Q9D516; -.
DR ProteomicsDB; 265688; -. [Q9D516-1]
DR ProteomicsDB; 265689; -. [Q9D516-2]
DR Antibodypedia; 54013; 51 antibodies from 12 providers.
DR DNASU; 67736; -.
DR Ensembl; ENSMUST00000005120; ENSMUSP00000005120; ENSMUSG00000004994. [Q9D516-2]
DR Ensembl; ENSMUST00000098578; ENSMUSP00000096177; ENSMUSG00000004994. [Q9D516-1]
DR GeneID; 67736; -.
DR KEGG; mmu:67736; -.
DR UCSC; uc009mmk.2; mouse. [Q9D516-1]
DR UCSC; uc012ghi.2; mouse. [Q9D516-2]
DR CTD; 67736; -.
DR MGI; MGI:1914986; Ccdc130.
DR VEuPathDB; HostDB:ENSMUSG00000004994; -.
DR eggNOG; KOG2990; Eukaryota.
DR GeneTree; ENSGT00530000063615; -.
DR HOGENOM; CLU_050402_3_1_1; -.
DR InParanoid; Q9D516; -.
DR OMA; RNMSVWD; -.
DR OrthoDB; 1583452at2759; -.
DR PhylomeDB; Q9D516; -.
DR TreeFam; TF313671; -.
DR BioGRID-ORCS; 67736; 19 hits in 78 CRISPR screens.
DR ChiTaRS; Ccdc130; mouse.
DR PRO; PR:Q9D516; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9D516; protein.
DR Bgee; ENSMUSG00000004994; Expressed in retinal neural layer and 110 other tissues.
DR ExpressionAtlas; Q9D516; baseline and differential.
DR Genevisible; Q9D516; MM.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR GO; GO:0008380; P:RNA splicing; IBA:GO_Central.
DR InterPro; IPR007590; Saf4/Yju2.
DR PANTHER; PTHR12111; PTHR12111; 1.
DR Pfam; PF04502; Saf4_Yju2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..385
FT /note="Probable splicing factor YJU2B"
FT /id="PRO_0000280046"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 182..214
FT /evidence="ECO:0000255"
FT COMPBIAS 258..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 40
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P13994"
FT MOD_RES 306
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P13994"
FT VAR_SEQ 192..198
FT /note="EKKKAMQ -> LMRTSSE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023900"
FT VAR_SEQ 199..385
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023901"
SQ SEQUENCE 385 AA; 43880 MW; D9BF85B6136A41B4 CRC64;
MGERKGQNKY YPPDFNPEKH GSLNRYHNSH PLRERARKLS QGILVIRFEM PYNIWCDGCK
NHIGMGVRYN AEKKKVGNYY TTPIYRFRMK CHLCVNYIEM QTDPANCDYV IVSGASRKEE
RWDMEDNEQV LTTEHEKKEK LETDAMFRLE HGEADRSTLK KALPTLSHIQ EAQNAWKDDF
ALNSMLRRHF REKKKAMQEE EEKDQALQAK ASLAIPLVPE SEDDRRLAAL LRLHTLDSYE
DKQRMKRTEI IHRSWFPSAQ GPSASSSKAS SVLKKLCQGR RPPPSSTGTV GDLGIVRRKS
RDVPESPQCA ADNSLSEEQR RPPGTTQGSK TLEEAAEASR TSKTSESKRN CSDQAFPLGS
SQEDLLNPNT PNASLVADYS DSESE
