YJW5_YEAST
ID YJW5_YEAST Reviewed; 1758 AA.
AC P40889; D6VVX3; P40887; Q05371; Q9UQW2;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Y' element ATP-dependent helicase YJL225C;
DE EC=3.6.4.12;
GN OrderedLocusNames=YJL225C; ORFNames=HRF393/HRD1054, HRF393/HRD732, J0202;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP PRELIMINARY NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7725802; DOI=10.1002/yea.320101216;
RA Vandenbol M., Durand P., Bolle P.-A., Dion C., Portetelle D., Hilger F.;
RT "Sequence analysis of a 40.2 kb DNA fragment located near the left telomere
RT of yeast chromosome X.";
RL Yeast 10:1657-1662(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP FUNCTION, AND INDUCTION.
RX PubMed=9837911; DOI=10.1074/jbc.273.50.33360;
RA Yamada M., Hayatsu N., Matsuura A., Ishikawa F.;
RT "Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is
RT induced in survivors defective for telomerase.";
RL J. Biol. Chem. 273:33360-33366(1998).
CC -!- FUNCTION: Catalyzes DNA unwinding and is involved in telomerase-
CC independent telomere maintenance. {ECO:0000269|PubMed:9837911}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- INDUCTION: Induced in absence of telomerase TLC1.
CC {ECO:0000269|PubMed:9837911}.
CC -!- SIMILARITY: Belongs to the helicase family. Yeast subtelomeric Y'
CC repeat subfamily. {ECO:0000305}.
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DR EMBL; Z48148; CAA88141.1; ALT_SEQ; Genomic_DNA.
DR EMBL; Z48148; CAA88142.1; ALT_SEQ; Genomic_DNA.
DR EMBL; Z34098; CAA83986.1; ALT_SEQ; Genomic_DNA.
DR EMBL; Z34098; CAA83985.1; ALT_SEQ; Genomic_DNA.
DR EMBL; Z49498; CAA89520.1; -; Genomic_DNA.
DR EMBL; Z49500; CAA89522.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08589.1; -; Genomic_DNA.
DR PIR; S57015; S57015.
DR RefSeq; NP_012311.1; NM_001181657.1.
DR AlphaFoldDB; P40889; -.
DR BioGRID; 33558; 4.
DR DIP; DIP-4705N; -.
DR STRING; 4932.YJL225C; -.
DR PaxDb; P40889; -.
DR PRIDE; P40889; -.
DR EnsemblFungi; YJL225C_mRNA; YJL225C; YJL225C.
DR GeneID; 853231; -.
DR KEGG; sce:YJL225C; -.
DR SGD; S000003760; YJL225C.
DR VEuPathDB; FungiDB:YJL225C; -.
DR eggNOG; ENOG502QWCT; Eukaryota.
DR GeneTree; ENSGT00940000153173; -.
DR HOGENOM; CLU_003044_2_0_1; -.
DR BioCyc; YEAST:G3O-31646-MON; -.
DR Reactome; R-SCE-5689880; Ub-specific processing proteases.
DR Reactome; R-SCE-936440; Negative regulators of DDX58/IFIH1 signaling.
DR PRO; PR:P40889; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P40889; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0004386; F:helicase activity; ISS:SGD.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR021646; Sir1_ORC-binding.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF11603; Sir1; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome;
KW Repeat.
FT CHAIN 1..1758
FT /note="Y' element ATP-dependent helicase YJL225C"
FT /id="PRO_0000102208"
FT DOMAIN 668..845
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 900..1051
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 1142..1384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1361..1384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 681..688
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 1758 AA; 197565 MW; 7E1D052AF97F8CA0 CRC64;
MKVSDRRKFE KANFDEFESA LNNKNDLVHC PSITLFESIP TEVRSFYEDE KSGLIKVVKF
RTGAMDRKRS FEKVVISVMV GKNVKKFLTF VEDEPDFQGG PIPSKYLIPK KINLMVYTLF
QVHTLKFNRK DYDTLSLFYL NRGYYNELSF RVLERCHEIA SARPNDSSTM RTFTDFVSGA
PIVRSLQKST IRKYGYNLAP YMFLLLHVDE LSIFSAYQAS LPGEKKVDTE RLKRDLCPRK
PIEIKYFSQI CNDMMNKKDR LGDILHIILR ACALNFGAGP RGGAGDEEDR SITNEEPIIP
SVDEHGLKVC KLRSPNTPRR LRKTLDAVKA LLVSSCACTA RDLDIFDDNN GVAMWKWIKI
LYHEVAQETT LKDSYRITLV PSSDGISLLA FAGPQRNVYV DDTTRRIQLY TDYNKNGSSE
PRLKTLDGLT SDYVFYFVTV LRQMQICALG NSYDAFNHDP WMDVVGFEDP NQVTNRDISR
IVLYSYMFLN TAKGCLVEYA TFRQYMRELP KNAPQKLNFR EMRQGLIALG RHCVGSRFET
DLYESATSEL MANHSVQTGR NIYGVDSFSL TSVSGTTATL LQERASERWI QWLGLESDYH
CSFSSTRNAE DVVAGEAASS NHHQKISRVT RKRPREPKST NDILVAGQKL FGSSFEFRDL
HQLRLCYEIY MADTPSVAVQ APPGYGKTEL FHLPLIALAS KGDVEYVSFL FVPYTVLLAN
CMIRLGRRGC LNVAPVRNFI EEGYDGVTDL YVGIYDDLAS TNFTDRIAAW ENIVECTFRT
NNVKLGYLIV DEFHNFETEV YRQSQFGGIT NLDFDAFEKA IFLSGTAPEA VADAALQRIG
LTGLAKKSMD INELKRSEDL SRGLSSYPTR MFNLIKEKSE VPLGHVHKIR KKVESQPEEA
LKLLLALFES EPESKAIVVA STTNEVEELA CSWRKYFRVV WIHGKLGAAE KVSRTKEFVT
DGSMQVLIGT KLVTEGIDIK QLMMVIMLDN RLNIIELIQG VGRLRDGGLC YLLSRKNSWA
ARNRKGELPP IKEGCITEQV REFYGLESKK GKKGQHVGCC GSRTDLSADT VELIERMDRL
AEKQATASMS IVALPSSFQE SNSSDRYRKY CSSDEDSNTC IHGSANASTN ASTNAITTAS
TNVRTNATTN ASTNATTNAS TNASTNATTN ASTNATTNSS TNATTTASTN VRTSATTTAS
INVRTSATTT ESTNSSTNAT TTESTNSSTN ATTTESTNSN TSATTTASIN VRTSATTTES
TNSSTSATTT ASINVRTSAT TTKSINSSTN ATTTESTNSN TNATTTESTN SSTNATTTES
TNSSTNATTT ESTNSNTSAA TTESTNSNTS ATTTESTNAS AKEDANKDGN AEDNRFHPVT
DINKESYKRK GSQMVLLERK KLKAQFPNTS ENMNVLQFLG FRSDEIKHLF LYGIDIYFCP
EGVFTQYGLC KGCQKMFELC VCWAGQKVSY RRIAWEALAV ERMLRNDEEY KEYLEDIEPY
HGDPVGYLKY FSVKRREIYS QIQRNYAWYL AITRRRETIS VLDSTRGKQG SQVFRMSGRQ
IKELYFKVWS NLRESKTEVL QYFLNWDEKK CQEEWEAKDD TVVVEALEKG GVFQRLRSMT
SAGLQGPQYV KLQFSRHHRQ LRSRYELSLG MHLRDQIALG VTPSKVPHWT AFLSMLIGLF
YNKTFRQKLE YLLEQISEVW LLPHWLDLAN VEVLAADDTR VPLYMLMVAV HKELDSDDVP
DGRFDILLCR DSSREVGE
