YJY5_YEAST
ID YJY5_YEAST Reviewed; 510 AA.
AC P47090; D6VWJ1; Q66R65;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Uncharacterized endoplasmic reticulum membrane protein YJR015W;
GN OrderedLocusNames=YJR015W; ORFNames=J1448;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 639 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: To yeast SNG1. {ECO:0000305}.
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DR EMBL; X87611; CAA60938.1; -; Genomic_DNA.
DR EMBL; Z49515; CAA89539.1; -; Genomic_DNA.
DR EMBL; AY723836; AAU09753.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08807.1; -; Genomic_DNA.
DR PIR; S55204; S55204.
DR RefSeq; NP_012549.3; NM_001181673.3.
DR AlphaFoldDB; P47090; -.
DR BioGRID; 33771; 46.
DR DIP; DIP-1889N; -.
DR IntAct; P47090; 5.
DR MINT; P47090; -.
DR STRING; 4932.YJR015W; -.
DR TCDB; 9.B.316.1.1; the nitrosoguanidine resistance or duf3533 (ngr) family.
DR iPTMnet; P47090; -.
DR MaxQB; P47090; -.
DR PaxDb; P47090; -.
DR PRIDE; P47090; -.
DR EnsemblFungi; YJR015W_mRNA; YJR015W; YJR015W.
DR GeneID; 853472; -.
DR KEGG; sce:YJR015W; -.
DR SGD; S000003776; YJR015W.
DR VEuPathDB; FungiDB:YJR015W; -.
DR eggNOG; ENOG502QUA0; Eukaryota.
DR GeneTree; ENSGT00940000176467; -.
DR HOGENOM; CLU_020178_1_0_1; -.
DR InParanoid; P47090; -.
DR OMA; MANDTIT; -.
DR BioCyc; YEAST:G3O-31660-MON; -.
DR PRO; PR:P47090; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P47090; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR022703; DUF3533.
DR Pfam; PF12051; DUF3533; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..510
FT /note="Uncharacterized endoplasmic reticulum membrane
FT protein YJR015W"
FT /id="PRO_0000203085"
FT TOPO_DOM 1..89
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..312
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..349
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 371..381
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 403..416
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 438..474
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 475..495
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 496..510
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 38..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 324
FT /note="F -> S (in Ref. 3; AAU09753)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 510 AA; 58117 MW; CD1AB973D0042CBF CRC64;
MTSSLDDIEP TAYNNMEADE EYCRRNDIHD LSSVVGDAVS QGVPDMDGQT TDSSKDPEPN
SEDKKAFPPS SGSFFSPNLQ GQRKKVLLKF VFTNCLLAII CFTMFVLFWG ALYDTSKYLH
KVKLLVVIQE PPVVILDNNS SMVVPSISYA LPTFINKIPC DWDIYNSPTF QAKFDVNTPQ
QVNDKVVDLV YDEKYWFAIN IKPNATETLF ESLINDTAPL FNSTLFNQVV YETGRDPTNL
KSTILPVAQT IEEYYHTFYT LNYLPPLLTN ITQVYRYALT NNARYIAAAG KYNYEYYDHR
PFTDRILLAP TQIGVVYCLL LTFFQFLLYG PLHVEMAKVL RPANGLIYRI AMSWFTFFFA
SLFFCTTTAI FQVDFTKSFG RGGFVVYWMS TWLFMLAAGG ANENAVMLVI TLGPQYLGFW
ILSFVILNIA PSFFPLALNN NVYRYGYMMP VHNVIDIYRV IFFDVTRRKM GRNYGILVAL
IALNTALLPF VGKYASRKLK QKALVAAKQS
