ID   YK038_HUMAN             Reviewed;         196 AA.
AC   Q8IYB0;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Putative uncharacterized protein MGC39545;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   VARIANT [LARGE SCALE ANALYSIS] TYR-129.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- CAUTION: Product of a dubious gene prediction. {ECO:0000305}.
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DR   EMBL; AP000708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC036197; AAH36197.1; -; mRNA.
DR   RefSeq; NP_001288780.1; NM_001301851.1.
DR   AlphaFoldDB; Q8IYB0; -.
DR   BioGRID; 135623; 1.
DR   iPTMnet; Q8IYB0; -.
DR   PhosphoSitePlus; Q8IYB0; -.
DR   BioMuta; -; -.
DR   PaxDb; Q8IYB0; -.
DR   PeptideAtlas; Q8IYB0; -.
DR   PRIDE; Q8IYB0; -.
DR   neXtProt; NX_Q8IYB0; -.
DR   OrthoDB; 1325685at2759; -.
DR   PhylomeDB; Q8IYB0; -.
DR   PathwayCommons; Q8IYB0; -.
DR   BioGRID-ORCS; 403312; 1 hit in 75 CRISPR screens.
DR   GenomeRNAi; 403312; -.
DR   Pharos; Q8IYB0; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q8IYB0; protein.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..196
FT                   /note="Putative uncharacterized protein MGC39545"
FT                   /id="PRO_0000342657"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          70..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          153..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         129
FT                   /note="D -> Y (in a colorectal cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_044325"
FT   CONFLICT        63
FT                   /note="L -> P (in Ref. 2; AAH36197)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   196 AA;  21182 MW;  29D68226D9E1BFC9 CRC64;
     MPSGEERRDR QKGRRAGCDT SSTPSNTAPR IPEPGAHPTA ARPATAQPPR SLLPPVCSKT
     IALPASAAAA SGSDTAGMRG LGKAPHSGEG HERGRGNSKM KACNNYQYGY LAKPDTSFWI
     KCRRWLLADA GRHTQRPFWT FRVSHSPLLE AEAGRPSDVS QLQLGSDLKP KMRRPAGELF
     SPKDAGWELD PAEKSE