ID   YK16_SCHPO              Reviewed;        1183 AA.
AC   Q9HDY4; Q9UTZ3;
DT   29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Putative ATP-dependent RNA helicase PB1A10.06c;
DE            EC=3.6.4.13;
GN   ORFNames=SPAPB1A10.06c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 582-780, AND SUBCELLULAR
RP   LOCATION.
RC   STRAIN=ATCC 38364 / 968;
RX   PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA   Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA   Hiraoka Y.;
RT   "Large-scale screening of intracellular protein localization in living
RT   fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL   Genes Cells 5:169-190(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10759889}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CU329670; CAC21479.1; -; Genomic_DNA.
DR   EMBL; AB027915; BAA87219.1; -; Genomic_DNA.
DR   RefSeq; NP_593520.1; NM_001018954.2.
DR   AlphaFoldDB; Q9HDY4; -.
DR   SMR; Q9HDY4; -.
DR   BioGRID; 279793; 4.
DR   STRING; 4896.SPAPB1A10.06c.1; -.
DR   iPTMnet; Q9HDY4; -.
DR   MaxQB; Q9HDY4; -.
DR   PaxDb; Q9HDY4; -.
DR   PRIDE; Q9HDY4; -.
DR   EnsemblFungi; SPAPB1A10.06c.1; SPAPB1A10.06c.1:pep; SPAPB1A10.06c.
DR   GeneID; 2543371; -.
DR   KEGG; spo:SPAPB1A10.06c; -.
DR   PomBase; SPAPB1A10.06c; -.
DR   VEuPathDB; FungiDB:SPAPB1A10.06c; -.
DR   eggNOG; KOG0926; Eukaryota.
DR   HOGENOM; CLU_001832_0_3_1; -.
DR   InParanoid; Q9HDY4; -.
DR   OMA; GHQHGCM; -.
DR   PhylomeDB; Q9HDY4; -.
DR   Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q9HDY4; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR   GO; GO:0005524; F:ATP binding; ISM:PomBase.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; ISO:PomBase.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..1183
FT                   /note="Putative ATP-dependent RNA helicase PB1A10.06c"
FT                   /id="PRO_0000055192"
FT   DOMAIN          408..585
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          611..831
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   REGION          1..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          165..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          673..696
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           522..525
FT                   /note="DEAH box"
FT   COMPBIAS        27..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..92
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..249
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        250..274
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        681..696
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         421..428
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   1183 AA;  133996 MW;  BA8183F0B4CA8BAF CRC64;
     MGRLRKRFNE KGRQSGIQKM LNLKRARLHR SVREQESSSE VHANPEPDNQ DSNAEILIDV
     PKEERQKRKQ ELKDQLLKEN EGSISSKKKK RLDKYIENKL KKEEVASLIA KLAEERIDTS
     LLSSSKNLGK QATAKEKLKK SLLEEKLGLP LSDADSRLYK VVDVETTTTK SSTAETNAPE
     KYSTRSGFGF GFSTGTNESE ITPNIKVLPP KKKKNASWGK MLNEDPEYDS AEEDYLSTDS
     EEFSEDSDNS SEENKDTNEP STKDAEKTVP EDVVNLRSEQ KLQPSFGHPE FENEDFDLET
     SEDDSSDDAT ERASRFKSWA NKQILGADVG EKSHDVAPDN KIDNPDADMV RAQRMPRKLK
     MREEDVEPTA DDIEIKGRKT TYTIINRPPE IQESRLALPI VAEEQRIMEQ IFANDVVIIC
     GATGSGKTTQ LPQFLFEAGF SSPESENPGM IAITQPRRVA AVSIAKRVSE ELTGFSSKVS
     YQIRFDSTIN PDTAIKFMTD GILLRELSSD FLLTAYSAVI VDEAHERSVN TDILLGLLSR
     IVRLRREMSK SDQKVKPLKL IIMSATLRVT DFSENKLLFS VPPPIIKIDA RQYPVSIHFN
     RTTKPDYLQD AFDKVCLIHK RLPAGSILVF LTGQQEVEQL CQMLRKRFVR SFRPLKSRAR
     IVVSRKTMSV ENEDLQSETE DIDQVPTSSS SSVTYDDESE PMYVLPLYSL LTTEDQMKVF
     DSSPEGHRMC IVATNVAETS ITIPNIRYVV DCGKAKERVY NEKTSVQKFE VRWISKANAD
     QRAGRAGRTG PGHCYRLYSS AVFDSSFPLH SLPEILRTPV ESIVLQMKNM NIDNIANFPF
     PTSPGRSRLE KSLKLLSNLG AIDSEGVLTK LGEQMSLFPL SPRFSKMLII GQQHGCLPYV
     IALVSALSIN QLFVSKQSLL YDAHDKNSRS EETDLIDDDE IKQKEEYKNR MRGYFNAISR
     FQAIDPDAPA LSLLSAVCAY DYASDKRKFC KENYLREKAL EEVTNLRKQI IGLLKRYMVR
     VEKEFFKLQL KPPTSVQIKA LRQFIASAYI DQVALYDKEK RGYVTLFPSG SEVVQFVPDR
     TYNIDSEYVV YLSLHESRSG RVYMSPLTEI SPEHLARLAK NTTLLSYSKP LSYPPIRYLD
     NATKRECWVI PILSANIGTG SPSWNLPAVQ IIQKRINGRW VNC