YK213_PLAF7
ID YK213_PLAF7 Reviewed; 2545 AA.
AC Q8IIG1; A0A144A2K5;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 2.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Uncharacterized protein PF3D7_1120600;
GN ORFNames=PF11_0213, PF3D7_1120600;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000305}
RP SYNTHESIS OF 125-149, DEVELOPMENTAL STAGE, AND POSSIBLE CANDIDATE MALARIA
RP EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed during the asexual cell-cycle on the
CC cell surface of the host erythrocytes. {ECO:0000269|PubMed:17653272}.
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR EMBL; LN999945; CZT98868.1; -; Genomic_DNA.
DR RefSeq; XP_001347884.2; XM_001347848.2.
DR AlphaFoldDB; Q8IIG1; -.
DR SMR; Q8IIG1; -.
DR STRING; 5833.PF11_0213; -.
DR PRIDE; Q8IIG1; -.
DR EnsemblProtists; CZT98868; CZT98868; PF3D7_1120600.
DR GeneID; 810760; -.
DR KEGG; pfa:PF3D7_1120600; -.
DR VEuPathDB; PlasmoDB:PF3D7_1120600; -.
DR HOGENOM; CLU_228218_0_0_1; -.
DR InParanoid; Q8IIG1; -.
DR OMA; YMDKIYM; -.
DR Proteomes; UP000001450; Chromosome 11.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR019153; DDRGK_dom-contain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR SMART; SM01128; DDRGK; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Merozoite; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..2545
FT /note="Uncharacterized protein PF3D7_1120600"
FT /id="PRO_0000356833"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 348..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1214..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 131..161
FT /evidence="ECO:0000255"
FT COILED 2303..2337
FT /evidence="ECO:0000255"
FT COMPBIAS 353..370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2545 AA; 303407 MW; 48DEDBC852FB2F64 CRC64;
MNKFFQILEY FKIELSINFS ITFIFINILL VFFSTFLYRN IKKVNDPDSY KTSYERKEKD
STFDEEENFD ILNIFSNDPK SVENIYELEN DIYNKSEESS ICSNHNKNLD EKTYKINKKK
VTIYLKLNEG LENIKQELHI IDRELKNILQ KEENLQLINE EENIIIEKTK SDKYDEKENK
SNDNILSKKH DDENINKSDI RNTLDSELKK KYELCKENNQ LLENHHNNDN NQEDNNICEI
EKQDYNNYNS DNKNHNDIFN YNYEDISLEK DKNIHHTKEI TKNDTLCNTL DSIKNNRPTE
EKTKNFNYNE TNIYEENKKL KDSIVNSKNG ENFLLKNNEQ NINNNIINVN QKQSSDHKKE
SFKIDTKKND QIEQNYQNGK NEKNEENEKN GMNEQNGKNE QNGKNEQNGK NEQNEQNDQI
EQNYQNDPND QNDQNDQNEK NDQNEKNDQN KKNEQNIGPK KTNEISYDSI NINISNNQNP
KLSNVFVEDI KRILPISNNN LENSITTIKN IDDPSNSTKQ ELQNSDYENM HANKKIENGK
ESFICDITSN TNITRNSMDI PNIMDRKKSE YDKEVDNVSI KKKSYINHNM QRENTREDPS
NNMDYTNKST SDSNDIENEN KMERCTNILG LDKRETVIKI NDINKDNKHT NGIKCEDKRK
STSIHMEDIN NSTNYLNNKE YNSKGENNNN ILGDDKREST FKIYDIQKSE YNSNDLQYDN
KRERTSINLD NGNKNNVDIN NYINVDDTKE RISINLDNVN KNNVDINNYI NDDNTKERTS
INLDNGNKNN VDINNYINDD NTKERTSINL DNGNKNNVDI NNYINDDNTK ERTSINLDNG
NKNNVDINNY INVDNTKERT SINLDNGNKK NVDINNYIND DNTKERTSIN LDNGNKNNVD
INNCINVEDK RERYSHILNI NKRESIIKIN DMKKTKSDSN DIKINDNRTE MYSNIFEINE
KERTSIKVDT VKENKSDSND IENGNKIERH SNVLYINPTK FDPIKINDIN KKGERYYDNI
ENEDKREIYT NNDEYMDKRE SNTNHIYINK KESYLENAKD VIKKESPLNN VEDTKKEESY
SKNIENANKE EYESNEETYV NKMEEDSNDI EDISNRKYEY KEGQYLNKGE KYINNIDNVS
IKESYYNKRE KESIEISNLN KRESCTSNIN NFRIRENQSN MVEYENKRKS DNIEINNLNK
ADIYVNSIKN VSKRNSSYNK KERDSKKDRD SVYDENRRKS SAYQINDIYN IRDKSKEKID
MDTIQDMNKR KSYVDNIHIT NKKYSDINNA EDVIREKKYE DYNISVMYNM HNKRDQRKES
NINIYNDNNM RRSTINKIND ENSMHNVKNE IKNIDNNNNV DKINVNKSNT DKIYMDKIYM
DKIYMDKRYM DKRYMDKRYM NKRYMDKIYM DKIYMDKIYM DKIYMDNEYM TDNIIKKNDK
YNNNNNNNNS DVVEYVNERK HTSLINEHYL YERKSNVDKM KDINKGENDI LYDVYNNSEK
KNTKSSLYRN PEIITQGGND NINNMNEHIS SLNKVYRISN KKSNNNYKGQ DYTYIVNENS
GRNSSMYNNI NNSDNMNKKE CDFINDKENI NKRISEIYDL RQINHNESNI ENMENIKNME
NIKNMENIKN MENIEHIKNM ENMEHIKNIQ NIEHIKNIEN IQNIQNMEHI KNIESIQNIQ
NMEHIQNIEN IQNIENIQNI ENIKTIENIK KNIENINNKG SLMVNSNNIN ENIKKESDIY
KIECDDDHMC DVTKIKGVDK QMSDTHKIKY DDNEKNNENK RKSGINKVFD IIKRTMDSYN
IYNLSKCKID EDNIYMLNEK KKNNINNMNK RKSENTYNIN EREKDDMNRR MTENTYNLNK
EKNLSVHNIK NIQPYNINNN IYEKTNDTID NLNETGKNNT NDISIKGSDK NKEYKFYDNE
NKDNINMIIR DTINMSNLNN NISDNMQMAI HKEEKNIHKM NRKITYTNNL YNINESKTEY
TININEQEEK SDFINNDNIK MDNEDKLYNC NERNNHIHKE NKRNDIKYDN FKKDNIRKNM
DNTKNIENMN NIDNMDNTKH IENVNNMKNI ENVNNINNID NMDNKKHIEN VNNMKNIENV
NNINNIDNMD NKKHIENINN MKNMENMNNI NNIENMNNMK NIENMNNMKN IENMNNINNI
ENINNMKNIQ NINNIENMDN MNNTKYIENM DNMNNIENMN NINNYNKIYD VNIINNKNYD
STYNELYEKD NQEENKNICN DKLDNSINEK TKYMKTLREY FVKSEKEIED QKKNNMNDMY
TRREEEKIKD NEDWKLYDFK NLKEKYKFQM NMKDSEINQL QNNLIDEFKE LNEVSKLKNN
LKGKTYNSNI GEEMLEENKE KQHGNYVGEY FDRNDMILKE RIFEYAKHKT SIDMLKHPDD
IKRNSKDLKK WKSQVITKKY ADDWLSSDVL LSCFLNFIKL KKYVNITELS VKFQTTTDDI
REKLEELEEQ DMINGVLDEK GNYIYLSQEE INKLCFEIQS KGKVNTHDDF VKICNKVISL
SVNDKDMEKL KEEEEKIIKA KTEIF
