YK42_SCHPO
ID YK42_SCHPO Reviewed; 566 AA.
AC Q9P7G6;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Transcription factor P14E8.02 {ECO:0000312|EMBL:CAB77003.1};
GN ORFNames=SPAP14E8.02;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAB77003.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP FUNCTION, AND INDUCTION.
RX PubMed=15195092; DOI=10.1038/ng1377;
RA Rustici G., Mata J., Kivinen K., Lio P., Penkett C.J., Burns G., Hayles J.,
RA Brazma A., Nurse P., Baehler J.;
RT "Periodic gene expression program of the fission yeast cell cycle.";
RL Nat. Genet. 36:809-817(2004).
RN [3] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4] {ECO:0000305}
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-379 AND SER-382, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Probable transcriptional regulatory protein Required for G1/S
CC progression. {ECO:0000269|PubMed:15195092}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- INDUCTION: Transcriptionally regulated in a cell cycle-dependent manner
CC by the mlu1 cell-cycle box binding factor (MBF) complex independently
CC of sep1 and ace2. Strongly up-regulated in cells arrested in S phase by
CC hydroxyurea. {ECO:0000269|PubMed:15195092}.
CC -!- SIMILARITY: Belongs to the PLM2/TOS4 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB77003.1; -; Genomic_DNA.
DR RefSeq; NP_593538.1; NM_001018972.2.
DR AlphaFoldDB; Q9P7G6; -.
DR BioGRID; 278504; 105.
DR STRING; 4896.SPAP14E8.02.1; -.
DR iPTMnet; Q9P7G6; -.
DR MaxQB; Q9P7G6; -.
DR PaxDb; Q9P7G6; -.
DR PRIDE; Q9P7G6; -.
DR EnsemblFungi; SPAP14E8.02.1; SPAP14E8.02.1:pep; SPAP14E8.02.
DR GeneID; 2542021; -.
DR KEGG; spo:SPAP14E8.02; -.
DR PomBase; SPAP14E8.02; -.
DR VEuPathDB; FungiDB:SPAP14E8.02; -.
DR eggNOG; ENOG502RZJP; Eukaryota.
DR HOGENOM; CLU_027207_0_0_1; -.
DR InParanoid; Q9P7G6; -.
DR OMA; KQHKQYF; -.
DR PhylomeDB; Q9P7G6; -.
DR PRO; PR:Q9P7G6; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000785; C:chromatin; ISO:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0003682; F:chromatin binding; ISO:PomBase.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; ISO:PomBase.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:PomBase.
DR CDD; cd00060; FHA; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR Pfam; PF00498; FHA; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..566
FT /note="Transcription factor P14E8.02"
FT /id="PRO_0000353195"
FT DOMAIN 86..137
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 73
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 379
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 382
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 566 AA; 64103 MW; 2BA96729AFA8A556 CRC64;
MNISSQNVLL PSPIPSSSPM ASHKKSWLSK HPNQSMTFEK PQLGQFVLTP EPSSNTFYAP
SSPASAVRRE PLSPMSFVRM RSHRVNKIGR SSQQCDHVLS TVDKAISRVH AIVTCTQDRM
IIECVGWNGM IVSDKMRKSV FHMKKNDRIV LVRPNSDACP VLDVFGYRVL LGWPSDSEDE
WEGNLNAKNY EENREPMSPS PQEALPLMPS SPPSQDYQND QNHLILYTNS ESIPKLNLRS
NELVYPPPSK DLLQKLLALE KDGQVEKSDC SKNTQLKPSF LPKNTDDLLN GTDDNNIVLR
EVKVSFENEK IESDDLDKNE EISEGEEYTP IEESKEPITV RRDSVIQIDE SSAGLTDVIS
ELNFTNHNDD SKNSNITTSN DSPVNEVEPM APELSSAVVE KKEPEDYESI SAVDENTNDS
NESLPSSHDY SESTKENSAP DSLLLGLVLD ELVFSTTSTT PLPALSHLFP SNMPLQLIQD
KLRDLAAKHP YFEEVKRYGT DANGDPLWSE WFYNPDVDDD LERRMRYAPL MRPVRSSRRV
HKQYYWKKPR ARPRSSGHSS RRRRLS
