ID   YK66_SCHPO              Reviewed;         612 AA.
AC   Q9US12; P78846;
DT   23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Putative zinc metalloproteinase C607.06c;
DE            EC=3.4.24.-;
GN   ORFNames=SPAC607.06c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 238-577.
RC   STRAIN=PR745;
RX   PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA   Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT   "Identification of open reading frames in Schizosaccharomyces pombe
RT   cDNAs.";
RL   DNA Res. 4:363-369(1997).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 1 zinc ion. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the peptidase M10B family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB63793.1; -; Genomic_DNA.
DR   EMBL; D89196; BAA13857.1; ALT_SEQ; mRNA.
DR   PIR; T42995; T42995.
DR   PIR; T50226; T50226.
DR   RefSeq; NP_593595.1; NM_001019026.2.
DR   AlphaFoldDB; Q9US12; -.
DR   SMR; Q9US12; -.
DR   BioGRID; 279600; 2.
DR   STRING; 4896.SPAC607.06c.1; -.
DR   MaxQB; Q9US12; -.
DR   PaxDb; Q9US12; -.
DR   PRIDE; Q9US12; -.
DR   EnsemblFungi; SPAC607.06c.1; SPAC607.06c.1:pep; SPAC607.06c.
DR   GeneID; 2543169; -.
DR   KEGG; spo:SPAC607.06c; -.
DR   PomBase; SPAC607.06c; -.
DR   VEuPathDB; FungiDB:SPAC607.06c; -.
DR   eggNOG; KOG4525; Eukaryota.
DR   HOGENOM; CLU_009601_2_1_1; -.
DR   InParanoid; Q9US12; -.
DR   OMA; ALRFRFH; -.
DR   PhylomeDB; Q9US12; -.
DR   PRO; PR:Q9US12; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0032153; C:cell division site; HDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; ISM:PomBase.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.100.10.30; -; 1.
DR   InterPro; IPR001229; Jacalin-like_lectin_dom.
DR   InterPro; IPR036404; Jacalin-like_lectin_dom_sf.
DR   InterPro; IPR021917; Unchr_Zn-peptidase-like.
DR   Pfam; PF12044; Metallopep; 1.
DR   SUPFAM; SSF51101; SSF51101; 1.
DR   PROSITE; PS51752; JACALIN_LECTIN; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Lectin; Metal-binding; Metalloprotease; Protease;
KW   Reference proteome; Zinc.
FT   CHAIN           1..612
FT                   /note="Putative zinc metalloproteinase C607.06c"
FT                   /id="PRO_0000078180"
FT   DOMAIN          477..612
FT                   /note="Jacalin-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01088"
FT   ACT_SITE        304
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         303
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         307
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
FT   BINDING         313
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10095"
SQ   SEQUENCE   612 AA;  68571 MW;  962073F3F4E84D05 CRC64;
     MSQIILDNIS QNETVYNRFV IIHGRVGPRA SYCPQTINVK HHENSFPEQT WVVTDLYFKA
     IIHVVPGDNT ILFTTDDGGK LELQVYYQLL VDNPFYCIAF IVGKDSDLSF DAPHGAKNDI
     DEGIRKLRCA AYLWQAFTAE CMYRNGYGRR SFRIEESVQP DTMSCLSPWG TERLTATINI
     LRSDKTAEEI RSVPPDQLFH IAGDAVDKLH LPEPWHYMCM FLDTRYDPST QKIRGHVALG
     GGTDMHKLGV FGSHSLHSFP SALEYVVPVF SDARRIPSYL ANDANESSTI WECANIGIGA
     MLHELGHTLG CPHQPDGIML RSYPIFNRSF TTREFECVRT GSKGLAPVLA KDECSWHHLD
     MLRFFYHPCF KLPSDPTYPS DIETNYFVKG ETITFVNSTG IFLIEIEYNG QTKGWKEFNP
     PVGEASLTDA EIRSLSNASS NQDYRVRVLS RNFKCIDLNN VPEIIKNAKV ESSFGTVYRS
     ERYGLRGCNG KELSNILIAP EKFKPTKIRV HCGLALDGIE VFFGDESVLL GNRGGSPHDF
     EIQGSQIVGF QIRCGAWVDG ISIVLENGKT SPFYGNANGG GLKSYLVPKG FQLVGFYGTL
     GPFMDSIGFF IK