YK86_CAEEL
ID YK86_CAEEL Reviewed; 988 AA.
AC P34352; C8JQN6; Q2V4Y1; Q8TA78;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 4.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Uncharacterized protein C30A5.10;
DE Flags: Precursor;
GN ORFNames=C30A5.10;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P34352-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P34352-2; Sequence=VSP_041807, VSP_041808;
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DR EMBL; FO080290; CCD62658.1; -; Genomic_DNA.
DR EMBL; FO080290; CCD62657.1; -; Genomic_DNA.
DR PIR; S44780; S44780.
DR RefSeq; NP_498793.3; NM_066392.3. [P34352-1]
DR RefSeq; NP_498794.3; NM_066393.4. [P34352-2]
DR AlphaFoldDB; P34352; -.
DR SMR; P34352; -.
DR BioGRID; 533183; 1.
DR STRING; 6239.C30A5.10a; -.
DR EPD; P34352; -.
DR PaxDb; P34352; -.
DR EnsemblMetazoa; C30A5.10a.1; C30A5.10a.1; WBGene00016242. [P34352-1]
DR EnsemblMetazoa; C30A5.10b.1; C30A5.10b.1; WBGene00016242. [P34352-2]
DR GeneID; 3565865; -.
DR KEGG; cel:CELE_C30A5.10; -.
DR UCSC; C30A5.10a; c. elegans.
DR UCSC; C30A5.6; c. elegans. [P34352-1]
DR CTD; 3565865; -.
DR WormBase; C30A5.10a; CE46462; WBGene00016242; -. [P34352-1]
DR WormBase; C30A5.10b; CE46155; WBGene00016242; -. [P34352-2]
DR eggNOG; ENOG502SM9Y; Eukaryota.
DR GeneTree; ENSGT01030000234595; -.
DR HOGENOM; CLU_011339_0_0_1; -.
DR InParanoid; P34352; -.
DR OMA; ALTCLMC; -.
DR OrthoDB; 1655657at2759; -.
DR PhylomeDB; P34352; -.
DR PRO; PR:P34352; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00016242; Expressed in pharyngeal muscle cell (C elegans) and 2 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0001640; F:adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; IBA:GO_Central.
DR GO; GO:0001641; F:group II metabotropic glutamate receptor activity; IBA:GO_Central.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..988
FT /note="Uncharacterized protein C30A5.10"
FT /id="PRO_0000412824"
FT TRANSMEM 690..710
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 721..741
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 753..773
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 784..804
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 832..852
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 864..884
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 891..911
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 111..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 247
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 389
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 529
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 601
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 720
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 974
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 466
FT /note="I -> V (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_041807"
FT VAR_SEQ 467..988
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_041808"
SQ SEQUENCE 988 AA; 109305 MW; AFEFF8957E48C8AA CRC64;
MIRLVFLFLL VVLSVELLDF RSNNYRQIIN NALPTIDPQM ISQAQAAINP YTDIFVNPPN
SFVDFPMANI ASSGAFWQQP QSTVSQVAWN PPVSTNPSSS PAASTISFQS YQNPSTFPST
TTASTTTSTT TMPPTYQTTT KSVKKNTETL WTTSKSPMKL SKNPKPSKLN QKSSKSSATS
FDSAQLSVLS HRLLNDVLII PSSRRLYILA IIPIHQSSGQ QNFECGEIDV NAIVRMAAFL
EAQKTINESN LLKEIGVDIG AIIVDSCSTD LRSVADLYEL LSGTNIQKSD LIAIIRDDST
FMPNTEQIIR QLNLPVVNTF FTTRSAVQTS GTLPSMFLPI QSIISALRHY QSTCVNIIFD
EKYSESVSEF QQVALTEGIC VEVAIHVKNA SSTVSEMVVR RLLLSEARIV VALLSEDTWI
QMTKALRSEM VIAGRFVFIS MQDQRWTTSR KFIESWPTFE QHLISITPKT PINHEEEIKK
LTENIPKLSL PNLWLKQFWS SAFKCHVDNE DMGGSNSFSR ECATTQSLNI SQVAPDVDVA
SISLATHAIG IAFRSFVDRV CPGALVISLS DCVNDPFVGF HQSILDSDFV HHLSDIPVSF
NYSTGFRDIS LRINRVQFVE DRLQFSELGI VDPIQFTYQD SSDTATPSAR GSYLLMSSTC
PKSTCAKELA KSTIKQQLPS IVKALTDLEI MIFTIFSVLS ALTCLMCMYL KVISVSEYRN
LTAVTFLGLA FLSISAPAFI IPPNSISCSL RKLLFPIAIS ITIAPVFVKT VLIWKSIGSS
SSSVLIAFCI VLIQTVISTE WLLLASDSAT EFVSTLHGTM WRCSPGDSSE EMILLSCSLI
ALLSLLSFIF ALATLKHSQS LQHLMISILA ILFETALYVS LPLIPYKTRD TVMATTILIF
AFVALLLSHT GKSSAKKESE CGGTLQKTNE NWLQHVVQSP QDQMTLVKNY HTASTHAQST
MQFEKRSEDT LRRNTSLYGT EGYELPTP
