ID   YKA1_SCHPO              Reviewed;         583 AA.
AC   Q9US28;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Uncharacterized FAD-binding protein C1783.01;
GN   ORFNames=SPAC1783.01;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the flavoprotein pyridine nucleotide cytochrome
CC       reductase family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB66164.1; -; Genomic_DNA.
DR   PIR; T50103; T50103.
DR   RefSeq; NP_593656.1; NM_001019088.2.
DR   AlphaFoldDB; Q9US28; -.
DR   SMR; Q9US28; -.
DR   BioGRID; 278828; 1.
DR   STRING; 4896.SPAC1783.01.1; -.
DR   MaxQB; Q9US28; -.
DR   PaxDb; Q9US28; -.
DR   PRIDE; Q9US28; -.
DR   EnsemblFungi; SPAC1783.01.1; SPAC1783.01.1:pep; SPAC1783.01.
DR   GeneID; 2542364; -.
DR   KEGG; spo:SPAC1783.01; -.
DR   PomBase; SPAC1783.01; -.
DR   VEuPathDB; FungiDB:SPAC1783.01; -.
DR   eggNOG; KOG1158; Eukaryota.
DR   HOGENOM; CLU_001570_17_5_1; -.
DR   InParanoid; Q9US28; -.
DR   OMA; IYLCGSG; -.
DR   PhylomeDB; Q9US28; -.
DR   Reactome; R-SPO-1222556; ROS and RNS production in phagocytes.
DR   Reactome; R-SPO-1474151; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
DR   Reactome; R-SPO-203615; eNOS activation.
DR   Reactome; R-SPO-392154; Nitric oxide stimulates guanylate cyclase.
DR   Reactome; R-SPO-5218920; VEGFR2 mediated vascular permeability.
DR   Reactome; R-SPO-5578775; Ion homeostasis.
DR   Reactome; R-SPO-9009391; Extra-nuclear estrogen signaling.
DR   Reactome; R-SPO-9033241; Peroxisomal protein import.
DR   PRO; PR:Q9US28; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0030586; F:[methionine synthase] reductase activity; ISS:PomBase.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; ISM:PomBase.
DR   GO; GO:0010181; F:FMN binding; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0050667; P:homocysteine metabolic process; IBA:GO_Central.
DR   GO; GO:0009086; P:methionine biosynthetic process; ISS:PomBase.
DR   Gene3D; 1.20.990.10; -; 1.
DR   Gene3D; 3.40.50.80; -; 1.
DR   InterPro; IPR003097; CysJ-like_FAD-binding.
DR   InterPro; IPR017927; FAD-bd_FR_type.
DR   InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR   InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR   InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR   Pfam; PF00667; FAD_binding_1; 1.
DR   Pfam; PF00175; NAD_binding_1; 1.
DR   PRINTS; PR00371; FPNCR.
DR   SUPFAM; SSF52343; SSF52343; 1.
DR   SUPFAM; SSF63380; SSF63380; 1.
DR   PROSITE; PS51384; FAD_FR; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Reference proteome.
FT   CHAIN           1..583
FT                   /note="Uncharacterized FAD-binding protein C1783.01"
FT                   /id="PRO_0000310845"
FT   DOMAIN          162..424
FT                   /note="FAD-binding FR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00716"
SQ   SEQUENCE   583 AA;  65872 MW;  0EE994D1B0C54204 CRC64;
     MISHVLVKDT SCLKVRTSYK CFVKYFPKCS VQSSFHSYDE LAFSRRLYNL PRTLLNSRYY
     SNHSHGLVHG SKSPPSSQFL VPSFLQFNGQ LKALCNNSAF QALPIKLSDL QKHWPSLKPH
     PLPPKRVSLG IPSISNPPVD TVISDSPTSP HPPSFVQPHP PYGIFAAPIL DVRVLTNPGA
     VKRTYNLCLD ISKYPLLEGK DWKIGGSFGI MPPNSDAEVL HLAHLLKIPQ HELYVTKVLR
     TNGGRWPTIW GEDKPRCLYT SLYHIFKWCS DFISKPPTKS LIRLLAEHTL NPVEKSVLLA
     LSDFRQDESY CRICTQSCVT LPDILEAFPS CHPPVDHLIS ALPQLMPRWY SISNDPSLAN
     KRLEMAFTVQ EYHSPNGQSR TGICTGFLED LALAFLKARH DGSLANKKFT VPMFRGVQQN
     PFAKEFHNDG PMCLIGAGVG IAPFRGFVQR RLANAACTGK VWIIQGCRDQ KLDELYHGEW
     NTVPGHHKNP KCRAKKLVVE SRNGRREYVQ DAVRRHGDVI WDVLSHKNGR IYLCGSGNSF
     VSEIEKALMD VAMKYGKLSK EEAQKELKNW QKPMNCKLIK EVW