YKAA_CAEEL
ID YKAA_CAEEL Reviewed; 927 AA.
AC P34261; A0A0K3AR76; A0A0K3AU37; P34262;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 07-OCT-2020, sequence version 7.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Solute carrier family 12 protein B0303.11 {ECO:0000305};
GN ORFNames=B0303.11 {ECO:0000312|WormBase:B0303.11b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=1538779; DOI=10.1038/356037a0;
RA Sulston J., Du Z., Thomas K., Wilson R., Hillier L., Staden R.,
RA Halloran N., Green P., Thierry-Mieg J., Qiu L., Dear S., Coulson A.,
RA Craxton M., Durbin R., Berks M., Metzstein M., Hawkins T., Ainscough R.,
RA Waterston R.;
RT "The C. elegans genome sequencing project: a beginning.";
RL Nature 356:37-41(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b {ECO:0000312|WormBase:B0303.11b};
CC IsoId=P34261-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:B0303.11a};
CC IsoId=P34261-2; Sequence=VSP_060749;
CC -!- SIMILARITY: Belongs to the SLC12A transporter family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284603; CTQ86554.1; -; Genomic_DNA.
DR EMBL; BX284603; CTQ86555.1; -; Genomic_DNA.
DR PIR; A88537; A88537.
DR PIR; S27792; S27792.
DR RefSeq; NP_001299854.1; NM_001312925.1. [P34261-2]
DR RefSeq; NP_001299855.1; NM_001312926.1. [P34261-1]
DR AlphaFoldDB; P34261; -.
DR SMR; P34261; -.
DR STRING; 6239.B0303.11; -.
DR EPD; P34261; -.
DR PaxDb; P34261; -.
DR PeptideAtlas; P34261; -.
DR PRIDE; P34261; -.
DR EnsemblMetazoa; B0303.11a.1; B0303.11a.1; WBGene00015131. [P34261-2]
DR EnsemblMetazoa; B0303.11a.2; B0303.11a.2; WBGene00015131. [P34261-2]
DR EnsemblMetazoa; B0303.11b.1; B0303.11b.1; WBGene00015131. [P34261-1]
DR GeneID; 176222; -.
DR KEGG; cel:CELE_B0303.11; -.
DR CTD; 176222; -.
DR WormBase; B0303.11a; CE50287; WBGene00015131; -.
DR WormBase; B0303.11b; CE50231; WBGene00015131; -.
DR eggNOG; KOG2083; Eukaryota.
DR HOGENOM; CLU_001883_0_0_1; -.
DR InParanoid; P34261; -.
DR OMA; EQMHELQ; -.
DR OrthoDB; 254933at2759; -.
DR PhylomeDB; P34261; -.
DR Reactome; R-CEL-426117; Cation-coupled Chloride cotransporters.
DR PRO; PR:P34261; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00015131; Expressed in larva and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IBA:GO_Central.
DR GO; GO:0008511; F:sodium:potassium:chloride symporter activity; IBA:GO_Central.
DR GO; GO:0006884; P:cell volume homeostasis; IBA:GO_Central.
DR GO; GO:0055064; P:chloride ion homeostasis; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0055075; P:potassium ion homeostasis; IBA:GO_Central.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0055078; P:sodium ion homeostasis; IBA:GO_Central.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827; PTHR11827; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..927
FT /note="Solute carrier family 12 protein B0303.11"
FT /id="PRO_0000054181"
FT TOPO_DOM 1..23
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..53
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..95
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 96..116
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..141
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 142..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 166..186
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..212
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 213..233
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 245..265
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..284
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 285..305
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 346..366
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 367
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 368..388
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 389..394
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 395..415
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 416..419
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 420..440
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 441..927
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 275
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT VAR_SEQ 515..532
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_060749"
SQ SEQUENCE 927 AA; 103354 MW; CEF98DB42FAB1802 CRC64;
MPSSTASSED APITSTAWMN WKDVFLKCVQ PMLAVVLLLR FSSIVDEAGF TTTIILVFFT
FLVSLVTGWS ACTVVSRKSS EVGFVKTMLA YSSTEFAISF SIIYLFCLLV ATSTFLTSAA
EAVLHIFSTF SLELLDGATH DLRLVSSVLS LITLALCMVR NRNARFVRTF IFALTCIAIA
LQLSSVMFRY GEYQLRRVSD RNAMIPSPPN EEISTIFAQL FPAAMCGLTI LNIGSKLQNT
APRGALIAIA VSACFYGAAA MLDYVEFFAR TSTSNSTGSA EYNEFLSYIY TTVPMAIVIT
LACVLSAVST LKYAAVILQS LGRSNQCRCI LWLAKGFGER DIPIRCLLLL STVQILVSAI
GSYDILCIPT TVFYLFAYAL FNFYVFLVKL SDPEIPSPPT LLSLAISAAC FIASLYTNRH
LALFIASIFA ISYCSLLYII RRERNEDGEE CPKSMYSSVL EQMHELQQEP DSRRHFHPQI
LLLSGSPAAR PGLVDFAHSI TRGKSLLICG YIIPKISNKV EQPMTWTEYL MQQSPCSRSY
LLQLKIDKQI NDWLRAREVN AFGAAICCTK QAEGANILLQ TAGLGRLRPN ILMLGYKTGW
EKLSKESISE YYGMLSNAFD KQVGVIIFRN EASGFDVTSS IRKNGAPIND DEDLAEYVDS
ATPKLADQGS QKKDVPRGKL LNTFRKMSMA VNKDLESGGR RSTSSSTRFQ VIDKHSISEP
DQKIIMAQMF RFRKRIPNAR IDVFWLREAG GLTMLAPYLL TQAGSFLEGA HIRVFTKTDG
KDNKRINEEQ KNMAAILRKF HIDSSDLHIL PEFSKPPCKQ TYDEFRAKID KYKVETSSSG
EPVDGSFDNN QIFNLREKTR SFLRASELIR EHSSDADLIV CTLPSARPEI PSPIYLGWID
MLSRQTPPTC LVRGNQVSMS ALRLKFP
