YKF0_YEAST
ID YKF0_YEAST Reviewed; 922 AA.
AC P35736; D6VXN7;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Uncharacterized protein YKL050C;
GN OrderedLocusNames=YKL050C; ORFNames=YKL263, YKL301;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-452.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8154189; DOI=10.1002/yea.320091212;
RA Purnelle B., Tettelin H., van Dyck L., Skala J., Goffeau A.;
RT "The sequence of a 17.5 kb DNA fragment on the left arm of yeast chromosome
RT XI identifies the protein kinase gene ELM1, the DNA primase gene PRI2, a
RT new gene encoding a putative histone and seven new open reading frames.";
RL Yeast 9:1379-1384(1993).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 410-922.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091862; DOI=10.1002/yea.320100008;
RA Rasmussen S.W.;
RT "Sequence of a 28.6 kb region of yeast chromosome XI includes the FBA1 and
RT TOA2 genes, an open reading frame (ORF) similar to a translationally
RT controlled tumour protein, one ORF containing motifs also found in plant
RT storage proteins and 13 ORFs with weak or no homology to known proteins.";
RL Yeast 10:S63-S68(1994).
RN [5]
RP INDUCTION.
RX PubMed=16467472; DOI=10.1128/ec.5.2.313-320.2006;
RA Slattery M.G., Liko D., Heideman W.;
RT "The function and properties of the Azf1 transcriptional regulator change
RT with growth conditions in Saccharomyces cerevisiae.";
RL Eukaryot. Cell 5:313-320(2006).
CC -!- INDUCTION: Expression is regulated by the AZF1 transcription factor.
CC {ECO:0000269|PubMed:16467472}.
CC -!- SIMILARITY: Belongs to the EIS1 family. {ECO:0000305}.
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DR EMBL; Z28050; CAA81885.1; -; Genomic_DNA.
DR EMBL; X75781; CAA53420.1; -; Genomic_DNA.
DR EMBL; X71621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK006944; DAA09107.1; -; Genomic_DNA.
DR PIR; S37871; S37871.
DR RefSeq; NP_012874.1; NM_001179616.1.
DR AlphaFoldDB; P35736; -.
DR SMR; P35736; -.
DR BioGRID; 34083; 109.
DR DIP; DIP-3002N; -.
DR IntAct; P35736; 1.
DR MINT; P35736; -.
DR STRING; 4932.YKL050C; -.
DR iPTMnet; P35736; -.
DR PaxDb; P35736; -.
DR PRIDE; P35736; -.
DR EnsemblFungi; YKL050C_mRNA; YKL050C; YKL050C.
DR GeneID; 853816; -.
DR KEGG; sce:YKL050C; -.
DR SGD; S000001533; YKL050C.
DR VEuPathDB; FungiDB:YKL050C; -.
DR eggNOG; ENOG502S8WV; Eukaryota.
DR GeneTree; ENSGT00940000176658; -.
DR HOGENOM; CLU_013228_0_0_1; -.
DR InParanoid; P35736; -.
DR OMA; WNDACER; -.
DR BioCyc; YEAST:G3O-31851-MON; -.
DR PRO; PR:P35736; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P35736; protein.
DR GO; GO:0070941; P:eisosome assembly; IBA:GO_Central.
DR InterPro; IPR024527; Eisosome1.
DR PANTHER; PTHR28298; PTHR28298; 1.
DR Pfam; PF12757; Eisosome1; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..922
FT /note="Uncharacterized protein YKL050C"
FT /id="PRO_0000203180"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 34..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..704
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..867
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 922 AA; 103144 MW; 362EE9A3F642DC8B CRC64;
MSLISALQTT DVESVQTSPE QITERKAVRV STLQESLHSS EMHRAAPETP RSISNSVHKL
KTIYSTYQQS GQPLSKEAIF RAKQKYGILN TPANYKTLGL GDSKSESVDL AARLASKRTK
VSPDDCVETA IEQKARGEAF KVTFSKIPLT PPEDVPITVN LGLKGRRDFL TRLAAQKALA
FSPSLDNSMK GTSDSSSVKK KRFSGAPIGN EFDANLVNPQ HPAGFKSLDL SKVLDGAERR
AISRVNDRLY PQKVNFKNGL QSSDQSGVSK ANKEVFKKGT LEKLEHSAEQ FLESHAGNER
QRLSDQQYMC AKGAADAVKD LDPKTLEDPD FAAREAQKKL YIKQVASPVV LNEAQKLANR
KLQDIDSRDT YMLLFGNQAY NKLAVNIALQ HYSVKQEEKK KIYLGGGLWM TPEEVNAVAK
KLISPVVNEI DERASRQRDV DKDIERRSRV LDQEYEDGNS MERAKEQNDG QLLLAMASKQ
QQEKEAKKAE EGQRYDQFVQ KMNIKLQQKE KELENARENR ENLRNELQER LSKNLSGEND
ELNDWNDACE RDLKNSSIEH YYAVRSHFDN LGNSERGYDE LLEERSKIQV EIERLVASIA
EHKTAIHGFG ETADAGGAIP AVQKQKIPTR KDLLDATVND PLVISAEMAK EEAEMATEEC
MLKELQVDEM IIIRNIMLRE CEKKLEEEKE TAKRSRRGTE ESKNNSNFSR DVIMSTPDNN
EKVTPIGKSA SPKDVVKSRF LSTYNTGKDI DSSASARSIT GVSGVLDDGP KTPTSNKENE
LIDDEVKSYK VHQAVDGTGE DSIANKRDKS SRPAANSGGS ITIEQFLFNK NADKQGLSKT
ESVTMKREPV VDQMDSKKGH DFTHCNDNGR RSFSGFSQGS IENDYSNEVT DDQDDQEGSE
IRVRDSNDSN TSPKESFFKE VI
