ID   YKJ7_SCHPO              Reviewed;         336 AA.
AC   Q9UT59;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Putative uncharacterized oxidoreductase C513.07;
DE            EC=1.1.1.-;
GN   ORFNames=SPAC513.07;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. Dihydroflavonol-4-reductase subfamily. {ECO:0000305}.
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DR   EMBL; CU329670; CAB58730.1; -; Genomic_DNA.
DR   PIR; T38902; T38902.
DR   RefSeq; NP_593981.1; NM_001019407.2.
DR   AlphaFoldDB; Q9UT59; -.
DR   SMR; Q9UT59; -.
DR   BioGRID; 279891; 38.
DR   STRING; 4896.SPAC513.07.1; -.
DR   iPTMnet; Q9UT59; -.
DR   MaxQB; Q9UT59; -.
DR   PaxDb; Q9UT59; -.
DR   PRIDE; Q9UT59; -.
DR   EnsemblFungi; SPAC513.07.1; SPAC513.07.1:pep; SPAC513.07.
DR   GeneID; 2543471; -.
DR   KEGG; spo:SPAC513.07; -.
DR   PomBase; SPAC513.07; -.
DR   VEuPathDB; FungiDB:SPAC513.07; -.
DR   eggNOG; KOG1502; Eukaryota.
DR   HOGENOM; CLU_007383_9_2_1; -.
DR   InParanoid; Q9UT59; -.
DR   OMA; NGIVAYC; -.
DR   PhylomeDB; Q9UT59; -.
DR   PRO; PR:Q9UT59; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0043892; F:methylglyoxal reductase (NADPH-dependent) activity; ISO:PomBase.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   GO; GO:0140041; P:cellular detoxification of methylglyoxal; IC:PomBase.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Oxidoreductase; Reference proteome.
FT   CHAIN           1..336
FT                   /note="Putative uncharacterized oxidoreductase C513.07"
FT                   /id="PRO_0000316223"
FT   BINDING         39
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250|UniProtKB:A0A059TC02"
FT   BINDING         166
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250|UniProtKB:A0A059TC02"
SQ   SEQUENCE   336 AA;  37462 MW;  9CBE726AF3FED785 CRC64;
     MSGKLVLVTG VTGFIGAHVA EQLLQAGYRV RGTVRSMEKA DELIRLNPGL KDKIEFVIVK
     DVSASNAFDG VLKDVELICH IASPFFVENV TDNKSQLLDP AVKGTLGILE AAQGVKSIKR
     IVITSSFAAV GNFQIDPHNN KVYTEKDWNP ITYEEALTTD NGIVAYCASK KLAEEAAREY
     VKEKKPSYDI CTINPPYVYG PPIHPMKNMD SLNTSNQIFW KLIDGSKEAT PFYYYYVDVR
     DVAAAHVFAL ENAKLSNGRM LVSKGVFTTG DICKVLRKEF PNKSDVIAEP VDITVDPSFF
     KLDNSFSKSL GFKYHSDEEC YVDTAKKLWE RAEEFK