ID   YKL2_CAEEL              Reviewed;         341 AA.
AC   P42169;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Putative casein kinase I C03C10.2;
DE            EC=2.7.11.1;
GN   ORFNames=C03C10.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1;
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CK1 Ser/Thr
CC       protein kinase family. Casein kinase I subfamily. {ECO:0000305}.
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DR   EMBL; Z35637; CAA84687.2; -; Genomic_DNA.
DR   PIR; T18875; T18875.
DR   RefSeq; NP_497820.2; NM_065419.2.
DR   AlphaFoldDB; P42169; -.
DR   SMR; P42169; -.
DR   STRING; 6239.C03C10.2; -.
DR   PaxDb; P42169; -.
DR   EnsemblMetazoa; C03C10.2.1; C03C10.2.1; WBGene00007269.
DR   GeneID; 182156; -.
DR   KEGG; cel:CELE_C03C10.2; -.
DR   UCSC; C03C10.2; c. elegans.
DR   CTD; 182156; -.
DR   WormBase; C03C10.2; CE44177; WBGene00007269; -.
DR   eggNOG; KOG1164; Eukaryota.
DR   GeneTree; ENSGT00970000196243; -.
DR   HOGENOM; CLU_019279_2_5_1; -.
DR   InParanoid; P42169; -.
DR   OMA; KNDERAM; -.
DR   OrthoDB; 1685139at2759; -.
DR   PhylomeDB; P42169; -.
DR   PRO; PR:P42169; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00007269; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR   GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
FT   CHAIN           1..341
FT                   /note="Putative casein kinase I C03C10.2"
FT                   /id="PRO_0000192868"
FT   DOMAIN          50..326
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   ACT_SITE        173
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10027"
FT   BINDING         56..64
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         79
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   341 AA;  39543 MW;  A4331AE21ADA1584 CRC64;
     MNKSKEAETD ITQIFPNLDI LPKKFSAKEL AERRIKKLHV APGSIFMNRW SIEGVIGNGG
     YGQIFMVMDV KKNDERAMKI EPKLRAEVIT KRMIMEQQVL MKMQGKTHIP TMYASGFNDQ
     FNFIIMQLLS MNVGDFRKRS PLGRLSKETV GRIAYQTLNA LKDIHDMGYV HRDVKPANIC
     FGVHAQNRHI LYLLDFGLVR RFKTESGVCI PWRINAGFKG TERYVSVRVH EKLEQTPWDD
     AFSVLYTAYE LVVGELPWRY LEDIHEIHGV KKLMNEVTKN GEMFKDIASI LVDFHKMILE
     CDPVVELPYE KLLECLKCLY SPKSLLEPYD WEDGYKTTLN I