ID   YKNX_BACSU              Reviewed;         377 AA.
AC   O31710; Q7BVR9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Putative efflux system component YknX {ECO:0000305};
GN   Name=yknX; OrderedLocusNames=BSU14350 {ECO:0000312|EMBL:CAB13308.1};
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Caldwell R.M., Ferrari E.;
RT   "Sequence analysis of the mobA-ampS region of the Bacillus subtilis
RT   chromosome.";
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND INDUCTION.
RC   STRAIN=168;
RX   PubMed=22707703; DOI=10.1128/jb.00223-12;
RA   Yamada Y., Tikhonova E.B., Zgurskaya H.I.;
RT   "YknWXYZ is an unusual four-component transporter with a role in protection
RT   against sporulation-delaying-protein-induced killing of Bacillus
RT   subtilis.";
RL   J. Bacteriol. 194:4386-4394(2012).
CC   -!- FUNCTION: Part of an unusual four-component transporter, which is
CC       required for protection against the killing factor SdpC (sporulation-
CC       delaying protein). {ECO:0000269|PubMed:22707703}.
CC   -!- SUBUNIT: Part of a complex composed of YknX, YknY and YknZ. The complex
CC       interacts with YknW. {ECO:0000269|PubMed:22707703}.
CC   -!- INTERACTION:
CC       O31710; O31710: yknX; NbExp=2; IntAct=EBI-6418873, EBI-6418873;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22707703};
CC       Single-pass membrane protein {ECO:0000255}.
CC   -!- INDUCTION: Expressed in exponential-phase cells.
CC       {ECO:0000269|PubMed:22707703}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000305}.
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DR   EMBL; AF012285; AAC24909.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB13308.1; -; Genomic_DNA.
DR   PIR; C69858; C69858.
DR   RefSeq; NP_389318.1; NC_000964.3.
DR   RefSeq; WP_003244902.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; O31710; -.
DR   SMR; O31710; -.
DR   STRING; 224308.BSU14350; -.
DR   TCDB; 3.A.1.122.2; the atp-binding cassette (abc) superfamily.
DR   PaxDb; O31710; -.
DR   PRIDE; O31710; -.
DR   EnsemblBacteria; CAB13308; CAB13308; BSU_14350.
DR   GeneID; 938774; -.
DR   KEGG; bsu:BSU14350; -.
DR   PATRIC; fig|224308.179.peg.1565; -.
DR   eggNOG; COG0845; Bacteria.
DR   InParanoid; O31710; -.
DR   OMA; TGKIQPE; -.
DR   PhylomeDB; O31710; -.
DR   BioCyc; BSUB:BSU14350-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Coiled coil; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..377
FT                   /note="Putative efflux system component YknX"
FT                   /id="PRO_0000376839"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          95..187
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   377 AA;  41707 MW;  7F0C65DBC134D082 CRC64;
     MKKVWIGIGI AVIVALFVGI NIYRSAAPTS GSAGKEVQTG SVEENEISST VMVPGTLKFS
     NEQYVFYEAD KGTLEDIKVK EGDKVKKGTA LVTYTNEQLS LEKEQNQLTS ESNRLQIDQI
     QEKLKALDSK ERELEKQVGK KEAEKQIESE RTELQMQKKT AEIELKQTEL QRQSLANRVS
     DLEVKSEIEG TVISVNQEAA SKKSDIQEPV IHIGNPKDLV VSGKLSEYDT LKVKKGQKVT
     LTSDVIQGKT WKGTVSAVGL VPDQQESAAA QGTEQAVQYP LQVKIKGNLP EGKPGFKFIM
     NIETDKRKAN TLPSKAVKKE DDQYYVYTVK DGKAKRVDVK IGEVTDDLTE IKEGLTQDDQ
     VILNPSDQVT DGMEVKS