YKNZ_BACSU
ID YKNZ_BACSU Reviewed; 397 AA.
AC O31712;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Uncharacterized ABC transporter permease YknZ {ECO:0000305};
GN Name=yknZ; OrderedLocusNames=BSU14370 {ECO:0000312|EMBL:CAB13310.1};
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Caldwell R.M., Ferrari E.;
RT "Sequence analysis of the mobA-ampS region of the Bacillus subtilis
RT chromosome.";
RL Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC 3610 / NRRL NRS-744 / VKM B-501;
RX PubMed=20713508; DOI=10.1101/gad.1945010;
RA Lopez D., Kolter R.;
RT "Functional microdomains in bacterial membranes.";
RL Genes Dev. 24:1893-1902(2010).
RN [4]
RP FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND INDUCTION.
RC STRAIN=168;
RX PubMed=22707703; DOI=10.1128/jb.00223-12;
RA Yamada Y., Tikhonova E.B., Zgurskaya H.I.;
RT "YknWXYZ is an unusual four-component transporter with a role in protection
RT against sporulation-delaying-protein-induced killing of Bacillus
RT subtilis.";
RL J. Bacteriol. 194:4386-4394(2012).
RN [5]
RP SUBCELLULAR LOCATION.
RC STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC 3610 / NRRL NRS-744 / VKM B-501;
RX PubMed=22882210; DOI=10.1111/j.1365-2958.2012.08205.x;
RA Yepes A., Schneider J., Mielich B., Koch G., Garcia-Betancur J.C.,
RA Ramamurthi K.S., Vlamakis H., Lopez D.;
RT "The biofilm formation defect of a Bacillus subtilis flotillin-defective
RT mutant involves the protease FtsH.";
RL Mol. Microbiol. 86:457-471(2012).
CC -!- FUNCTION: Part of an unusual four-component transporter, which is
CC required for protection against the killing factor SdpC (sporulation-
CC delaying protein). {ECO:0000269|PubMed:22707703}.
CC -!- SUBUNIT: Part of a complex composed of YknX, YknY and YknZ. The complex
CC interacts with YknW. {ECO:0000269|PubMed:22707703}.
CC -!- INTERACTION:
CC O31712; O31712: yknZ; NbExp=2; IntAct=EBI-6418851, EBI-6418851;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20713508,
CC ECO:0000269|PubMed:22707703, ECO:0000269|PubMed:22882210}; Multi-pass
CC membrane protein {ECO:0000255}. Membrane raft
CC {ECO:0000269|PubMed:20713508, ECO:0000269|PubMed:22882210}; Multi-pass
CC membrane protein {ECO:0000255}. Note=Present in detergent-resistant
CC membrane (DRM) fractions that may be equivalent to eukaryotic membrane
CC rafts; these rafts include proteins involved in signaling, molecule
CC trafficking and protein secretion. {ECO:0000269|PubMed:20713508,
CC ECO:0000269|PubMed:22882210}.
CC -!- INDUCTION: Expressed in exponential-phase cells.
CC {ECO:0000269|PubMed:22707703}.
CC -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family.
CC {ECO:0000305}.
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DR EMBL; AF012285; AAC24912.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB13310.1; -; Genomic_DNA.
DR PIR; E69858; E69858.
DR RefSeq; NP_389320.1; NC_000964.3.
DR RefSeq; WP_003232354.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; O31712; -.
DR SMR; O31712; -.
DR IntAct; O31712; 1.
DR STRING; 224308.BSU14370; -.
DR TCDB; 3.A.1.122.2; the atp-binding cassette (abc) superfamily.
DR PaxDb; O31712; -.
DR PRIDE; O31712; -.
DR EnsemblBacteria; CAB13310; CAB13310; BSU_14370.
DR GeneID; 938803; -.
DR KEGG; bsu:BSU14370; -.
DR PATRIC; fig|224308.179.peg.1567; -.
DR eggNOG; COG0577; Bacteria.
DR InParanoid; O31712; -.
DR OMA; GIMNITF; -.
DR PhylomeDB; O31712; -.
DR BioCyc; BSUB:BSU14370-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:2001070; F:starch binding; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR InterPro; IPR003838; ABC3_permease_dom.
DR InterPro; IPR005085; CBM25.
DR InterPro; IPR025857; MacB_PCD.
DR Pfam; PF02687; FtsX; 1.
DR Pfam; PF12704; MacB_PCD; 1.
DR SMART; SM01066; CBM_25; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..397
FT /note="Uncharacterized ABC transporter permease YknZ"
FT /id="PRO_0000049606"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 397 AA; 42125 MW; 3444BA73173C3DBC CRC64;
MSLLENIRMA LSSVLAHKMR SILTMLGIII GVGSVIVVVA VGQGGEQMLK QSISGPGNTV
ELYYMPSDEE LASNPNAAAE STFTENDIKG LKGIEGIKQV VASTSESMKA RYHEEETDAT
VNGINDGYMN VNSLKIESGR TFTDNDFLAG NRVGIISQKM AKELFDKTSP LGEVVWINGQ
PVEIIGVLKK VTGLLSFDLS EMYVPFNMMK SSFGTSDFSN VSLQVESADD IKSAGKEAAQ
LVNDNHGTED SYQVMNMEEI AAGIGKVTAI MTTIIGSIAG ISLLVGGIGV MNIMLVSVTE
RTREIGIRKS LGATRGQILT QFLIESVVLT LIGGLVGIGI GYGGAALVSA IAGWPSLISW
QVVCGGVLFS MLIGVIFGML PANKAAKLDP IEALRYE
