YKOC_BACSU
ID YKOC_BACSU Reviewed; 254 AA.
AC O34572; Q796M0;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Putative HMP/thiamine permease protein YkoC;
GN Name=ykoC; OrderedLocusNames=BSU13210;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Devine K.M.;
RT "Sequence of the Bacillus subtilis genome between xlyA and ykoR.";
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION IN HMP TRANSPORT.
RX PubMed=12376536; DOI=10.1074/jbc.m208965200;
RA Rodionov D.A., Vitreschak A.G., Mironov A.A., Gelfand M.S.;
RT "Comparative genomics of thiamin biosynthesis in procaryotes. New genes and
RT regulatory mechanisms.";
RL J. Biol. Chem. 277:48949-48959(2002).
RN [4]
RP FUNCTION IN HMP/THIAMINE TRANSPORT.
RC STRAIN=168 / PY79;
RX PubMed=16291685; DOI=10.1128/jb.187.23.8127-8136.2005;
RA Schyns G., Potot S., Geng Y., Barbosa T.M., Henriques A., Perkins J.B.;
RT "Isolation and characterization of new thiamine-deregulated mutants of
RT Bacillus subtilis.";
RL J. Bacteriol. 187:8127-8136(2005).
CC -!- FUNCTION: Part of the ABC transporter complex YkoCDEF that could
CC transport hydroxymethylpyrimidine (HMP) and/or thiamine. Could also
CC transport other HMP-containing products. Probably responsible for the
CC translocation of the substrate across the membrane (Probable).
CC {ECO:0000305|PubMed:12376536, ECO:0000305|PubMed:16291685}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (YkoD),
CC two transmembrane proteins (YkoC and YkoE) and a solute-binding protein
CC (YkoF). {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CbiQ family. {ECO:0000305}.
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DR EMBL; AJ002571; CAA05600.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB13178.1; -; Genomic_DNA.
DR PIR; G69858; G69858.
DR RefSeq; NP_389204.1; NC_000964.3.
DR RefSeq; WP_003245037.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; O34572; -.
DR SMR; O34572; -.
DR STRING; 224308.BSU13210; -.
DR TCDB; 3.A.1.30.1; the atp-binding cassette (abc) superfamily.
DR PaxDb; O34572; -.
DR PRIDE; O34572; -.
DR EnsemblBacteria; CAB13178; CAB13178; BSU_13210.
DR GeneID; 939836; -.
DR KEGG; bsu:BSU13210; -.
DR PATRIC; fig|224308.179.peg.1435; -.
DR eggNOG; COG0619; Bacteria.
DR OMA; IITLAYY; -.
DR PhylomeDB; O34572; -.
DR BioCyc; BSUB:BSU13210-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR InterPro; IPR003339; ABC/ECF_trnsptr_transmembrane.
DR Pfam; PF02361; CbiQ; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..254
FT /note="Putative HMP/thiamine permease protein YkoC"
FT /id="PRO_0000289288"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 254 AA; 28042 MW; 3CE2E4480B6EB774 CRC64;
MKQPLHLINP TVKAAAVFCC VVMLSFIYNP YTPACFYIII VAGVLLAAGI PLKKWLLFTI
PFLILAFGCV WTAAVFGKVP TTPDNFLFQA GPISINSDNV SVGISLGFRI LCFSALSMMF
VFTTDPILFM LSLVQQCRLS PKLAYGVIAG FRFLPLLKDE VQLIQQAHKI RGGAAESGII
NKISALKRYT IPLLASAIRK AERTALAMES KGFTGSRNRT YYRTLSVNRR DWVFFCLVLL
LFAGSFLVSL CFAS
