ID   YKP3_KLULA              Reviewed;         594 AA.
AC   P05469;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Uncharacterized killer plasmid pGKl-2 protein 3;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OG   Plasmid pGKl-2.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=3041369; DOI=10.1093/nar/16.13.5863;
RA   Tommasino M., Ricci S., Galeotti C.L.;
RT   "Genome organization of the killer plasmid pGKL2 from Kluyveromyces
RT   lactis.";
RL   Nucleic Acids Res. 16:5863-5878(1988).
CC   -!- FUNCTION: The presence of the two linear plasmids, termed pGKL1 and
CC       pGKL2, in strains of Kluyveromyces lactis confers the killer phenotype
CC       to the host cell, by promoting the secretion of a toxin able to inhibit
CC       the growth of sensitive strains.
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DR   EMBL; X07776; CAA30604.1; -; Genomic_DNA.
DR   PIR; S00961; S00961.
DR   AlphaFoldDB; P05469; -.
DR   SMR; P05469; -.
DR   Proteomes; UP000000598; Plasmid pGKL2.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   4: Predicted;
KW   Plasmid; Reference proteome.
FT   CHAIN           1..594
FT                   /note="Uncharacterized killer plasmid pGKl-2 protein 3"
FT                   /id="PRO_0000066278"
SQ   SEQUENCE   594 AA;  70527 MW;  6AE57D37618BE6B0 CRC64;
     MSGSFRSNFS IASIHLRLYE TIKSQSRIIL LFCRGMFKRF AKYKSNLESA MVDVELEARI
     QIPKPTNIIF EDETVITYYR STMYPSLIFR RINNGKLNSK ETVEKIKYGE VTICLSIEQT
     YSNMDIKFPI IPANKRTISR KRICENPIVD ITKCGDQYTL EIEFDYSNYM HIEKILKEWK
     NPYWPPVKPM EISSSNLAKK LANNEQWCIS PKADGIHVLV YSDGENQFIV HTNGYTEGDT
     NIKVNRIFEG ELMSNGEILY FDCLMWENKN ITKLDYIARY KYLENMNKKE IILFNNIYAI
     KKYLDKKHDF ETDGYIITNI KNRKKVYKSK FKNTVDLRYK NGYLLLENEE FSERSPKNVN
     EQLEEDKIYE FDMEMNLIRE RKDKTIANYK MPYDDNPIYK IAHSIGVPTL RYYHNKIKRE
     LLSMLPKTTL LDIGSAKGGD ITKWTNLKFE KVYAVDPNLE LRQRSKKVVE IRENIEDVYK
     MFDYESVSLF FVPWNDKFMD VINKAKYFVL ICMDKPVTVK EDCFECKIEN EKVILKIPDT
     QTSEYVEENL IKYTDVFKKL KNWKHMKINR TMNTGSAQEI ELSRMYSYHF FSKK