YKQA_BACSU
ID YKQA_BACSU Reviewed; 277 AA.
AC P39759;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Putative gamma-glutamylcyclotransferase YkqA;
DE EC=2.3.2.-;
GN Name=ykqA; Synonyms=ylxU, yzaB; OrderedLocusNames=BSU14500;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / JH642;
RA Kobayashi K., Sato T., Kobayashi Y.;
RT "The nucleotide sequence analysis of kinC region.";
RL Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8002614; DOI=10.1128/jb.177.1.166-175.1995;
RA Ledeaux J.R., Grossman A.D.;
RT "Isolation and characterization of kinC, a gene that encodes a sensor
RT kinase homologous to the sporulation sensor kinases KinA and KinB in
RT Bacillus subtilis.";
RL J. Bacteriol. 177:166-175(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8969500; DOI=10.1099/13500872-142-11-3033;
RA Winters P., Caldwell R.M., Enfield L., Ferrari E.;
RT "The ampS-nprE (124 degrees-127 degrees) region of the Bacillus subtilis
RT 168 chromosome: sequencing of a 27 kb segment and identification of several
RT genes in the area.";
RL Microbiology 142:3033-3037(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS).
RG Northeast structural genomics consortium (NESG);
RT "Crystal structure of YkqA from Bacillus subtilis.";
RL Submitted (FEB-2009) to the PDB data bank.
CC -!- FUNCTION: Putative gamma-glutamylcyclotransferase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the gamma-glutamylcyclotransferase family.
CC {ECO:0000305}.
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DR EMBL; D37799; BAA07050.1; -; Genomic_DNA.
DR EMBL; L34803; AAA66184.1; -; Genomic_DNA.
DR EMBL; AF012285; AAC24925.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB13323.1; -; Genomic_DNA.
DR PIR; I39872; I39872.
DR RefSeq; NP_389333.1; NC_000964.3.
DR RefSeq; WP_003245146.1; NZ_JNCM01000035.1.
DR PDB; 2QIK; X-ray; 1.35 A; A=1-277.
DR PDBsum; 2QIK; -.
DR AlphaFoldDB; P39759; -.
DR SMR; P39759; -.
DR STRING; 224308.BSU14500; -.
DR PaxDb; P39759; -.
DR PRIDE; P39759; -.
DR EnsemblBacteria; CAB13323; CAB13323; BSU_14500.
DR GeneID; 939408; -.
DR KEGG; bsu:BSU14500; -.
DR PATRIC; fig|224308.179.peg.1580; -.
DR eggNOG; COG2105; Bacteria.
DR eggNOG; COG3703; Bacteria.
DR InParanoid; P39759; -.
DR OMA; YGSCMDN; -.
DR BioCyc; BSUB:BSU14500-MON; -.
DR EvolutionaryTrace; P39759; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0061929; F:gamma-glutamylaminecyclotransferase activity; IEA:InterPro.
DR CDD; cd06661; GGCT_like; 2.
DR InterPro; IPR009288; AIG2-like_dom.
DR InterPro; IPR039126; GGACT.
DR InterPro; IPR013024; GGCT-like.
DR InterPro; IPR036568; GGCT-like_sf.
DR PANTHER; PTHR12510; PTHR12510; 1.
DR Pfam; PF06094; GGACT; 1.
DR SUPFAM; SSF110857; SSF110857; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Acyltransferase; Reference proteome; Transferase.
FT CHAIN 1..277
FT /note="Putative gamma-glutamylcyclotransferase YkqA"
FT /id="PRO_0000184788"
FT ACT_SITE 205
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 8..11
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT STRAND 3..7
FT /evidence="ECO:0007829|PDB:2QIK"
FT HELIX 18..21
FT /evidence="ECO:0007829|PDB:2QIK"
FT STRAND 25..39
FT /evidence="ECO:0007829|PDB:2QIK"
FT STRAND 44..47
FT /evidence="ECO:0007829|PDB:2QIK"
FT STRAND 54..63
FT /evidence="ECO:0007829|PDB:2QIK"
FT HELIX 65..74
FT /evidence="ECO:0007829|PDB:2QIK"
FT STRAND 79..87
FT /evidence="ECO:0007829|PDB:2QIK"
FT STRAND 90..98
FT /evidence="ECO:0007829|PDB:2QIK"
FT STRAND 108..110
FT /evidence="ECO:0007829|PDB:2QIK"
FT HELIX 115..122
FT /evidence="ECO:0007829|PDB:2QIK"
FT STRAND 126..132
FT /evidence="ECO:0007829|PDB:2QIK"
FT HELIX 135..137
FT /evidence="ECO:0007829|PDB:2QIK"
FT HELIX 140..144
FT /evidence="ECO:0007829|PDB:2QIK"
FT HELIX 148..150
FT /evidence="ECO:0007829|PDB:2QIK"
FT STRAND 154..161
FT /evidence="ECO:0007829|PDB:2QIK"
FT STRAND 164..171
FT /evidence="ECO:0007829|PDB:2QIK"
FT STRAND 174..180
FT /evidence="ECO:0007829|PDB:2QIK"
FT STRAND 185..193
FT /evidence="ECO:0007829|PDB:2QIK"
FT HELIX 195..197
FT /evidence="ECO:0007829|PDB:2QIK"
FT HELIX 198..204
FT /evidence="ECO:0007829|PDB:2QIK"
FT TURN 205..210
FT /evidence="ECO:0007829|PDB:2QIK"
FT STRAND 211..221
FT /evidence="ECO:0007829|PDB:2QIK"
FT STRAND 224..236
FT /evidence="ECO:0007829|PDB:2QIK"
FT HELIX 245..258
FT /evidence="ECO:0007829|PDB:2QIK"
FT HELIX 261..273
FT /evidence="ECO:0007829|PDB:2QIK"
SQ SEQUENCE 277 AA; 31659 MW; A7191FBEF4C56DE3 CRC64;
MNSLLFVYGT LRKHEKNHHL LAQSACINEQ ARTKGSLFAA KEGPTVVFND EDEGYIYGEV
YEADELCIHK LDQFFQGYHK QTVFVETDVG IKIALIYFMN KDGCAGFTKI SSGDWKEHQM
ISKSKNPIYY FAYGSCMDNA RFQKAGVDHY FQDPVGRAVL KGYTTRFTLK REDGSRADML
EDGGTTEGVL YRIPYSALSY LYKREGVESL TYRPAFVDVE AGGRHYKDCL TFLVLQKEAE
IAPPQHYQIE IERGAELYLS PEFTEKLKRH MNSLPKG
