YKT62_ARATH
ID YKT62_ARATH Reviewed; 199 AA.
AC Q9LVM9;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=VAMP-like protein YKT62 {ECO:0000303|PubMed:15919093};
DE Short=AtYKT62 {ECO:0000303|PubMed:15919093};
DE AltName: Full=ATGP1-like protein;
DE Flags: Precursor;
GN Name=YKT62 {ECO:0000303|PubMed:15919093};
GN OrderedLocusNames=At5g58180 {ECO:0000312|Araport:AT5G58180};
GN ORFNames=MCK7.5 {ECO:0000312|EMBL:BAA96909.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, INTERACTION WITH SYP41, AND SUBUNIT.
RX PubMed=15919093; DOI=10.1016/j.jmb.2005.04.061;
RA Chen Y., Shin Y.-K., Bassham D.C.;
RT "YKT6 is a core constituent of membrane fusion machineries at the
RT Arabidopsis trans-Golgi network.";
RL J. Mol. Biol. 350:92-101(2005).
RN [4]
RP FUNCTION.
RX PubMed=24021022; DOI=10.1186/1471-2091-14-22;
RA Kim S.-J., Bassham D.C.;
RT "Functional redundancy between trans-Golgi network SNARE family members in
RT Arabidopsis thaliana.";
RL BMC Biochem. 14:22-22(2013).
CC -!- FUNCTION: Involved in the secretory pathway (PubMed:15919093).
CC Essential for membrane fusion mediated by either SYP41 or SYP61;
CC triggers the fusion of phospholipid vesicles containing SYP41 or SYP61
CC and VTI12 (PubMed:15919093, PubMed:24021022).
CC {ECO:0000269|PubMed:15919093, ECO:0000269|PubMed:24021022}.
CC -!- SUBUNIT: Interacts with SYP41 (PubMed:15919093). Core constituent of
CC the SNARE complex required for membrane fusion at the trans-Golgi
CC network (PubMed:15919093). {ECO:0000269|PubMed:15919093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB019228; BAA96909.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97008.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97009.1; -; Genomic_DNA.
DR RefSeq; NP_001318826.1; NM_001345292.1.
DR RefSeq; NP_200626.1; NM_125203.2.
DR AlphaFoldDB; Q9LVM9; -.
DR SMR; Q9LVM9; -.
DR BioGRID; 21174; 1.
DR STRING; 3702.AT5G58180.1; -.
DR PaxDb; Q9LVM9; -.
DR PRIDE; Q9LVM9; -.
DR ProteomicsDB; 242939; -.
DR EnsemblPlants; AT5G58180.1; AT5G58180.1; AT5G58180.
DR EnsemblPlants; AT5G58180.2; AT5G58180.2; AT5G58180.
DR GeneID; 835930; -.
DR Gramene; AT5G58180.1; AT5G58180.1; AT5G58180.
DR Gramene; AT5G58180.2; AT5G58180.2; AT5G58180.
DR KEGG; ath:AT5G58180; -.
DR Araport; AT5G58180; -.
DR TAIR; locus:2161288; AT5G58180.
DR eggNOG; KOG0861; Eukaryota.
DR HOGENOM; CLU_074848_2_0_1; -.
DR InParanoid; Q9LVM9; -.
DR OMA; PWPYLKE; -.
DR OrthoDB; 1362424at2759; -.
DR PhylomeDB; Q9LVM9; -.
DR PRO; PR:Q9LVM9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LVM9; baseline and differential.
DR Genevisible; Q9LVM9; AT.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031201; C:SNARE complex; IDA:UniProtKB.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006906; P:vesicle fusion; IDA:UniProtKB.
DR CDD; cd14824; Longin; 1.
DR CDD; cd15867; R-SNARE_YKT6; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR045848; R-SNARE_YKT6.
DR InterPro; IPR001388; Synaptobrevin.
DR InterPro; IPR042855; V_SNARE_CC.
DR Pfam; PF13774; Longin; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
DR PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Lipoprotein; Membrane; Methylation; Palmitate; Prenylation;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..196
FT /note="VAMP-like protein YKT62"
FT /id="PRO_0000206749"
FT PROPEP 197..199
FT /note="Removed in mature form"
FT /evidence="ECO:0000250|UniProtKB:O15498"
FT /id="PRO_0000370847"
FT DOMAIN 7..131
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT DOMAIN 139..199
FT /note="v-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
FT MOD_RES 196
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250|UniProtKB:O15498"
FT LIPID 195
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:O15498"
FT LIPID 196
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:O15498"
SQ SEQUENCE 199 AA; 22909 MW; 3A031F8088FA5582 CRC64;
MKITALLVLK CDPETREPVI LANVSDLSQF GKFSFYRSNF EEFIVFIART VARRTPPGQR
QSVKHEEYKV HAYNINGLCA VGFMDDHYPV RSAFSLLNQV LDVYQKDYGD TWRFENSSQP
WPYLKEASDK FRDPAEADKL LKIQRELDET KIILHKTIDG VLARGEKLDS LVEKSSELSL
ASKMFYKQAK KTNSCCTLL
