YKT6_BOVIN
ID YKT6_BOVIN Reviewed; 198 AA.
AC Q3T000;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Synaptobrevin homolog YKT6;
DE EC=2.3.1.-;
DE Flags: Precursor;
GN Name=YKT6;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Vesicular soluble NSF attachment protein receptor (v-SNARE)
CC mediating vesicle docking and fusion to a specific acceptor cellular
CC compartment. Functions in endoplasmic reticulum to Golgi transport; as
CC part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in
CC early/recycling endosome to TGN transport; as part of a SNARE complex
CC composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase
CC activity. {ECO:0000250|UniProtKB:O15498}.
CC -!- SUBUNIT: Identified in 2 different SNARE complexes; the first one
CC composed of GOSR1, GOSR2 and STX5 and the second one composed of BET1L,
CC GOSR1 and STX5. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic
CC vesicle membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Lipid-
CC anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Probably
CC cycles through vesicles between Golgi and endosomes. {ECO:0000250}.
CC -!- DOMAIN: The longin domain regulates palmitoylation and membrane
CC targeting. {ECO:0000250}.
CC -!- PTM: Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is
CC required for Golgi targeting. {ECO:0000250|UniProtKB:O15498}.
CC -!- PTM: Farnesylation is required for Golgi targeting.
CC {ECO:0000250|UniProtKB:O15498}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR EMBL; BC102627; AAI02628.1; -; mRNA.
DR RefSeq; NP_001030219.1; NM_001035047.1.
DR AlphaFoldDB; Q3T000; -.
DR SMR; Q3T000; -.
DR STRING; 9913.ENSBTAP00000000341; -.
DR PaxDb; Q3T000; -.
DR PRIDE; Q3T000; -.
DR Ensembl; ENSBTAT00000000341; ENSBTAP00000000341; ENSBTAG00000000274.
DR GeneID; 507409; -.
DR KEGG; bta:507409; -.
DR CTD; 10652; -.
DR VEuPathDB; HostDB:ENSBTAG00000000274; -.
DR VGNC; VGNC:37030; YKT6.
DR eggNOG; KOG0861; Eukaryota.
DR GeneTree; ENSGT00390000015164; -.
DR HOGENOM; CLU_074848_3_0_1; -.
DR InParanoid; Q3T000; -.
DR OMA; ITDHEYP; -.
DR OrthoDB; 1362424at2759; -.
DR TreeFam; TF105606; -.
DR Reactome; R-BTA-204005; COPII-mediated vesicle transport.
DR Reactome; R-BTA-8980692; RHOA GTPase cycle.
DR Reactome; R-BTA-9013408; RHOG GTPase cycle.
DR Reactome; R-BTA-9013423; RAC3 GTPase cycle.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000000274; Expressed in corpus epididymis and 108 other tissues.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:HGNC-UCL.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:HGNC-UCL.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; ISS:HGNC-UCL.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:HGNC-UCL.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Ensembl.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; ISS:HGNC-UCL.
DR GO; GO:0006903; P:vesicle targeting; ISS:HGNC-UCL.
DR CDD; cd14824; Longin; 1.
DR CDD; cd15867; R-SNARE_YKT6; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR045848; R-SNARE_YKT6.
DR InterPro; IPR042855; V_SNARE_CC.
DR Pfam; PF13774; Longin; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport;
KW Golgi apparatus; Lipoprotein; Membrane; Methylation; Palmitate;
KW Phosphoprotein; Prenylation; Protein transport; Reference proteome;
KW Transferase; Transport.
FT CHAIN 1..195
FT /note="Synaptobrevin homolog YKT6"
FT /id="PRO_0000280708"
FT PROPEP 196..198
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000396660"
FT DOMAIN 8..131
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT DOMAIN 138..198
FT /note="v-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
FT MOD_RES 159
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15498"
FT MOD_RES 195
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 194
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 195
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 198 AA; 22467 MW; 73F331ED76ED0E33 CRC64;
MKLYSLSVLY KGESKTVLLK AAYDVSSFSF FQRSSVQEFM TFTSQLIVER SAKGSRASVK
EQEYLCHVYV RNDSLAGVVI ADSEYPSRVA FTLLEKVLDE FSKQVDRIDW PTGSPDTIRY
SGLDSQLSRY QNPREADPMT KVQAELDETK IILHNTMESL LERGEKLDDL VSKSEVLGIQ
SKAFYKTARK QNSCCAIM
