YKT6_DANRE
ID YKT6_DANRE Reviewed; 198 AA.
AC Q7ZUN8;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Synaptobrevin homolog YKT6;
DE EC=2.3.1.-;
DE Flags: Precursor;
GN Name=ykt6; ORFNames=zgc:55536;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney marrow;
RX PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA Look A.T., Chen Z.;
RT "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Vesicular soluble NSF attachment protein receptor (v-SNARE)
CC mediating vesicle docking and fusion to a specific acceptor cellular
CC compartment. Functions in endoplasmic reticulum to Golgi transport; as
CC part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in
CC early/recycling endosome to TGN transport; as part of a SNARE complex
CC composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase
CC activity. {ECO:0000250|UniProtKB:O15498}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic
CC vesicle membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Lipid-
CC anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Probably
CC cycles through vesicles between Golgi and endosomes. {ECO:0000250}.
CC -!- DOMAIN: The longin domain regulates palmitoylation and membrane
CC targeting. {ECO:0000250}.
CC -!- PTM: Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is
CC required for Golgi targeting. {ECO:0000250|UniProtKB:O15498}.
CC -!- PTM: Farnesylation is required for Golgi targeting.
CC {ECO:0000250|UniProtKB:O15498}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR EMBL; AY391470; AAQ91282.1; -; mRNA.
DR EMBL; BC048049; AAH48049.1; -; mRNA.
DR RefSeq; NP_957386.1; NM_201092.1.
DR AlphaFoldDB; Q7ZUN8; -.
DR SMR; Q7ZUN8; -.
DR STRING; 7955.ENSDARP00000121331; -.
DR PaxDb; Q7ZUN8; -.
DR PeptideAtlas; Q7ZUN8; -.
DR GeneID; 394067; -.
DR KEGG; dre:394067; -.
DR CTD; 10652; -.
DR ZFIN; ZDB-GENE-040426-733; ykt6.
DR eggNOG; KOG0861; Eukaryota.
DR InParanoid; Q7ZUN8; -.
DR OrthoDB; 1362424at2759; -.
DR PhylomeDB; Q7ZUN8; -.
DR Reactome; R-DRE-204005; COPII-mediated vesicle transport.
DR Reactome; R-DRE-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DRE-6811438; Intra-Golgi traffic.
DR Reactome; R-DRE-8980692; RHOA GTPase cycle.
DR Reactome; R-DRE-9013148; CDC42 GTPase cycle.
DR Reactome; R-DRE-9013149; RAC1 GTPase cycle.
DR Reactome; R-DRE-9013408; RHOG GTPase cycle.
DR PRO; PR:Q7ZUN8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd14824; Longin; 1.
DR CDD; cd15867; R-SNARE_YKT6; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR045848; R-SNARE_YKT6.
DR InterPro; IPR042855; V_SNARE_CC.
DR Pfam; PF13774; Longin; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport;
KW Golgi apparatus; Lipoprotein; Membrane; Methylation; Palmitate;
KW Prenylation; Protein transport; Reference proteome; Transferase; Transport.
FT CHAIN 1..195
FT /note="Synaptobrevin homolog YKT6"
FT /id="PRO_0000280712"
FT PROPEP 196..198
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000396664"
FT DOMAIN 8..131
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT DOMAIN 138..198
FT /note="v-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
FT MOD_RES 195
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 194
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 195
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 198 AA; 22405 MW; 952FDFC8515B28B0 CRC64;
MKLYSLSVLH KGSTKANLLK ATYDLSSFSF FQRSSVQEFM TFTSALIVER SALGSRASVK
EQEYLCHVYV RNDNLGGVVI ADSEYPSRVC FTLLDKVLDE FSRQVNSIDW PSGSPATIQY
TALDSHLARY QNPREADAMT KVQAELDETK IILHNTMESL LERGEKLDDL VQKSEHLGNQ
SKAFYKTARK QNSCCEIM
