ID   YKW2_YEAST              Reviewed;         705 AA.
AC   P35995; D6VWY1;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Uncharacterized transcriptional regulatory protein YKL222C;
GN   OrderedLocusNames=YKL222C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8091865; DOI=10.1002/yea.320100011;
RA   Alexandraki D., Tzermia M.;
RT   "Sequencing of a 13.2 kb segment next to the left telomere of yeast
RT   chromosome XI revealed five open reading frames and recent recombination
RT   events with the right arms of chromosomes III and V.";
RL   Yeast 10:S81-S91(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8196765; DOI=10.1038/369371a0;
RA   Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA   Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA   Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA   Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA   Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA   Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA   Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA   Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA   Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA   Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA   Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA   Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA   Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA   Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA   Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA   Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA   Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA   Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA   Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA   van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA   von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA   Becker I., Mewes H.-W.;
RT   "Complete DNA sequence of yeast chromosome XI.";
RL   Nature 369:371-378(1994).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; X75950; CAA53551.1; -; Genomic_DNA.
DR   EMBL; Z28222; CAA82067.1; -; Genomic_DNA.
DR   EMBL; BK006944; DAA08947.1; -; Genomic_DNA.
DR   PIR; S38066; S38066.
DR   RefSeq; NP_012700.1; NM_001179787.1.
DR   AlphaFoldDB; P35995; -.
DR   BioGRID; 33943; 37.
DR   DIP; DIP-5690N; -.
DR   STRING; 4932.YKL222C; -.
DR   PaxDb; P35995; -.
DR   PRIDE; P35995; -.
DR   EnsemblFungi; YKL222C_mRNA; YKL222C; YKL222C.
DR   GeneID; 853658; -.
DR   KEGG; sce:YKL222C; -.
DR   SGD; S000001705; YKL222C.
DR   VEuPathDB; FungiDB:YKL222C; -.
DR   eggNOG; ENOG502SJDI; Eukaryota.
DR   GeneTree; ENSGT00940000176356; -.
DR   HOGENOM; CLU_010594_0_0_1; -.
DR   InParanoid; P35995; -.
DR   OMA; YLENLWH; -.
DR   BioCyc; YEAST:G3O-31977-MON; -.
DR   PRO; PR:P35995; -.
DR   Proteomes; UP000002311; Chromosome XI.
DR   RNAct; P35995; protein.
DR   GO; GO:0072686; C:mitotic spindle; IDA:SGD.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS51450; LRR; 2.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   4: Predicted;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..705
FT                   /note="Uncharacterized transcriptional regulatory protein
FT                   YKL222C"
FT                   /id="PRO_0000115000"
FT   DNA_BIND        24..52
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   705 AA;  82248 MW;  31BF148717D72E1C CRC64;
     MKNTELSQKK KLDRQSRRKP AKSCHFCRVR KLKCDRVRPF CGSCSSRNRK QCEYKENTSA
     MEDQLRKKYR RCSKLEMARR IEELESQLTK QSQPNIHEGQ NPLSNMRYLS SKHNRHILYG
     PTSYRAILAT QTDTFAKYRE EIWQVLKLSR NNWKREHHYS TLSEISSIET APPHSGSPSV
     IEYLCESLPN YEVLCEYLTD FFASDFYDSY QIVHKEKVLR DLQDCFVKGP RSHKTGQHTI
     ISLNLDSKKN YYKVGVMTAI MCLASHPKEV PEAIEVFHKV LTSFVSAKVF YTERVQFLFL
     RYLYINVAGL DGGDQSHCIF IHGLTIDTAI HMGLNEDLRR LYLSKNHPIE EIPYLERLWL
     WILFTDVKIS LSTGIPVRIN DDFVNKVRLE NYSSSGDILL YKTTLRLRNI MKQIHAREKP
     PDIPLIIEDL KKFTIKMFKP LDFYLNASNL NGNEFTELQL WHATLHMIGS LSNLYTLTHQ
     DFDARIFNFS VLAPLNSLHL CFNVLETYFE LDNSKLSSKS LCLSKKWPHL NNALFLIYVN
     AFRALIQIYT IFLQYMENKD IQLFIQRNSS ALTYSICPGD FEGPHNKCIS LKIAFKEMEN
     IFDHIHQEKL KPLTQIWQNS YYFSIIISME KIGRRAFNKG MKNIDEGPET ENDATENSLT
     TILNDLEGPL EDFSENFIDD ILGSPSAFFD TAISGWSNFE DFFSR